Ag-TiO2 Assisted Photocatalytic Degradation of Cytostatic  Drug Cyclophosphamide Under UV-VIS Light

Cristea, Ionut Nicolae; , Arcadie Sobetkii; Constantin, Lucian Alexandru; Constantin, Mirela Alina; Nitoi, Ines

Ionut Nicolae Cristea, Arcadie Sobetkii , Lucian Alexandru Constantin, Mirela Alina Constantin, Ines Nitoi

Ag-TiO2 Assisted Photocatalytic Degradation of Cytostatic Drug Cyclophosphamide Under UV-VIS Light

Abstract:

Cyclophosphamide (CP) is a commonly prescribed cytostatic drug that has cytotoxic, genotoxic, mutagenic, carcinogenic and teratogenic effects on living organisms, which asks for its elimination from any water source. The photocatalytic degradation of CP under UV-VIS irradiation was studied, using non-doped TiO2 and Ag- doped TiO2 (0.5-1.7% wt.). The catalysts were synthesized by vacuum deposition method. The influence of Ag concentration on the degradation performance of CP was investigated and an optimal content of 1.0% Ag was established. Using of this catalyst assures the pollutant degradation with a rate constant kCP = 6.59 x 10-4 s-1 and an efficiency ηCP = 99% after120 min irradiation time. Based on the results of the quenching experiments in the presence of suitable scavengers, a mechanism of photocatalytic degradation of CP has been proposed. This consists in the attack of free hydroxyl radicals and superoxide radicals on the pollutant. Also, the contribution of Ag to inhibition of charge recombination and the additional generation of superoxide radicals, which are responsible for the higher photocatalytic activity of Ag doped TiO2 compared to non-doped TiO2, was emphasised.

Keywords:
Cyclophosphamide; un-doped TiO2; Ag-doped TiO2; photocatalysis; reactive species

Issue: 2020, Volume 71, Issue 4

Pages: 347-355

Publication date: 2020/5/5

https://doi.org/10.37358/RC.20.4.8074

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CRISTEA, I.N., , A.S., CONSTANTIN, L.A., CONSTANTIN, M.A., NITOI, I., Ag-TiO2 Assisted Photocatalytic Degradation of Cytostatic Drug Cyclophosphamide Under UV-VIS Light, Rev. Chim., 71(4), 2020, 347-355.

Vancouver
Cristea IN, AS, Constantin LA, Constantin MA, Nitoi I. Ag-TiO2 Assisted Photocatalytic Degradation of Cytostatic Drug Cyclophosphamide Under UV-VIS Light. Rev. Chim.[internet]. 2020 Apr;71(4):347-355. Available from: https://doi.org/10.37358/RC.20.4.8074

APA 6th edition
Cristea, I.N., , A.S., Constantin, L.A., Constantin, M.A. & Nitoi, I. (2020). Ag-TiO2 Assisted Photocatalytic Degradation of Cytostatic Drug Cyclophosphamide Under UV-VIS Light. Revista de Chimie, 71(4), 347-355. https://doi.org/10.37358/RC.20.4.8074

Harvard
Cristea, I.N., , A.S., Constantin, L.A., Constantin, M.A., Nitoi, I. (2020). 'Ag-TiO2 Assisted Photocatalytic Degradation of Cytostatic Drug Cyclophosphamide Under UV-VIS Light', Revista de Chimie, 71(4), pp. 347-355. https://doi.org/10.37358/RC.20.4.8074

IEEE
I.N. Cristea, A.S. , L.A. Constantin, M.A. Constantin, I. Nitoi, "Ag-TiO2 Assisted Photocatalytic Degradation of Cytostatic Drug Cyclophosphamide Under UV-VIS Light". Revista de Chimie, vol. 71, no. 4, pp. 347-355, 2020. [online]. https://doi.org/10.37358/RC.20.4.8074

Text
Ionut Nicolae Cristea, Arcadie Sobetkii , Lucian Alexandru Constantin, Mirela Alina Constantin, Ines Nitoi,
Ag-TiO2 Assisted Photocatalytic Degradation of Cytostatic Drug Cyclophosphamide Under UV-VIS Light,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 347-355,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8074.
(https://revistadechimie.ro/Articles.asp?ID=8074)
Keywords: Cyclophosphamide; un-doped TiO2; Ag-doped TiO2; photocatalysis; reactive species

RIS
TY - JOUR
T1 - Ag-TiO2 Assisted Photocatalytic Degradation of Cytostatic Drug Cyclophosphamide Under UV-VIS Light
A1 - Cristea, Ionut Nicolae
A2 - , Arcadie Sobetkii
A3 - Constantin, Lucian Alexandru
A4 - Constantin, Mirela Alina
A5 - Nitoi, Ines
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 347
EP - 355
UR - https://doi.org/10.37358/RC.20.4.8074
KW - Cyclophosphamide
KW - un-doped TiO2
KW - Ag-doped TiO2
KW - photocatalysis
KW - reactive species
ER -

BibTex
@article{RevCh2020P347,
author = {Cristea Ionut Nicolae and Arcadie Sobetkii and Constantin Lucian Alexandru and Constantin Mirela Alina and Nitoi Ines},
title = {Ag-TiO2 Assisted Photocatalytic Degradation of Cytostatic Drug Cyclophosphamide Under UV-VIS Light},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {347-355},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8074},
url = {https://revistadechimie.ro/Articles.asp?ID=8074}
}

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