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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 4, 390-400

https://doi.org/10.37358/RC.20.4.8079

Bogdan-Catalin Alexandru, Monica Popa, Cosmin Pestean, Robert Purdoiu, Liviu Oana, Anne-Marie Constantin, Ramona Amina Popovici, Alina-Simona Sovrea, Carmen Georgiu, Gabriela Dogaru

The Effect of Type 1 Atellocolagen in Association with Blood Self-derivatives in Alveolar Bone Augumentation

Abstract:

The current experimental study was conducted in sheep, which present bone anisotropy and a predisposition to periodontal disease, with alveolar bone resorption, similar to that found in humans. In this study, alveolar bone augmentation was performed using a lyophilized bovine bone xenograft enriched with type 1 atelocollagen, which was combined with autologous platelet-rich plasma (PRP) and advanced platelet-rich fibrin (A-PRF) as a membrane. The results were radiologically and histologically evaluated at six weeks postoperatively. At that time, the transformation of the composite biomaterial was clearly visible, suggesting that the regeneration process started from the periphery of the augmentation mass, which was progressively transformed from a granular eosinophilic material into an undifferentiated hypercellular one, then into fibroblastic, cartilaginous tissue, and finally into new bone and desmodontal-like tissue. This process was most probably induced by all the compounds used, the growth factors found in autologous blood derivatives, including bone morphogenetic proteins (BMPs), as well as type 1 atelocollagen from the graft composition, especially in combination. The composite biomaterial at six weeks postoperatively provided excellent results regarding alveolar bone regeneration, and without any risk, as opposed to that found in overdose of recombinant growth factors.
Keywords:
PRP; A-PRF; BMP; sheep; bone augmentation; alveolar bone

Issue: 2020, Volume 71, Issue 4
Pages: 390-400
Publication date: 2020/5/5
https://doi.org/10.37358/RC.20.4.8079
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
ALEXANDRU, B., POPA, M., PESTEAN, C., PURDOIU, R., OANA, L., CONSTANTIN, A., POPOVICI, R.A., SOVREA, A., GEORGIU, C., DOGARU, G., The Effect of Type 1 Atellocolagen in Association with Blood Self-derivatives in Alveolar Bone Augumentation, Rev. Chim., 71(4), 2020, 390-400.

Vancouver
Alexandru B, Popa M, Pestean C, Purdoiu R, Oana L, Constantin A, Popovici RA, Sovrea A, Georgiu C, Dogaru G. The Effect of Type 1 Atellocolagen in Association with Blood Self-derivatives in Alveolar Bone Augumentation. Rev. Chim.[internet]. 2020 Apr;71(4):390-400. Available from: https://doi.org/10.37358/RC.20.4.8079


APA 6th edition
Alexandru, B., Popa, M., Pestean, C., Purdoiu, R., Oana, L., Constantin, A.,... Dogaru, G. (2020). The Effect of Type 1 Atellocolagen in Association with Blood Self-derivatives in Alveolar Bone Augumentation. Revista de Chimie, 71(4), 390-400. https://doi.org/10.37358/RC.20.4.8079


Harvard
Alexandru, B., Popa, M., Pestean, C., Purdoiu, R., Oana, L., Constantin, A., Popovici, R.A., Sovrea, A., Georgiu, C., Dogaru, G. (2020). 'The Effect of Type 1 Atellocolagen in Association with Blood Self-derivatives in Alveolar Bone Augumentation', Revista de Chimie, 71(4), pp. 390-400. https://doi.org/10.37358/RC.20.4.8079


IEEE
B. Alexandru, M. Popa, C. Pestean, R. Purdoiu, L. Oana, A. Constantin, R.A. Popovici, A. Sovrea, C. Georgiu, G. Dogaru, "The Effect of Type 1 Atellocolagen in Association with Blood Self-derivatives in Alveolar Bone Augumentation". Revista de Chimie, vol. 71, no. 4, pp. 390-400, 2020. [online]. https://doi.org/10.37358/RC.20.4.8079


Text
Bogdan-Catalin Alexandru, Monica Popa, Cosmin Pestean, Robert Purdoiu, Liviu Oana, Anne-Marie Constantin, Ramona Amina Popovici, Alina-Simona Sovrea, Carmen Georgiu, Gabriela Dogaru,
The Effect of Type 1 Atellocolagen in Association with Blood Self-derivatives in Alveolar Bone Augumentation,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 390-400,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8079.
(https://revistadechimie.ro/Articles.asp?ID=8079)
Keywords: PRP; A-PRF; BMP; sheep; bone augmentation; alveolar bone


RIS
TY - JOUR
T1 - The Effect of Type 1 Atellocolagen in Association with Blood Self-derivatives in Alveolar Bone Augumentation
A1 - Alexandru, Bogdan-Catalin
A2 - Popa, Monica
A3 - Pestean, Cosmin
A4 - Purdoiu, Robert
A5 - Oana, Liviu
A6 - Constantin, Anne-Marie
A7 - Popovici, Ramona Amina
A8 - Sovrea, Alina-Simona
A9 - Georgiu, Carmen
A10 - Dogaru, Gabriela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 390
EP - 400
UR - https://doi.org/10.37358/RC.20.4.8079
KW - PRP
KW - A-PRF
KW - BMP
KW - sheep
KW - bone augmentation
KW - alveolar bone
ER -


BibTex
@article{RevCh2020P390,
author = {Alexandru Bogdan-Catalin and Popa Monica and Pestean Cosmin and Purdoiu Robert and Oana Liviu and Constantin Anne-Marie and Popovici Ramona Amina and Sovrea Alina-Simona and Georgiu Carmen and Dogaru Gabriela},
title = {The Effect of Type 1 Atellocolagen in Association with Blood Self-derivatives in Alveolar Bone Augumentation},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {390-400},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8079},
url = {https://revistadechimie.ro/Articles.asp?ID=8079}
}
 
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