Risks and Benefits Associated with Tribulus terrestris Products Assessed by Phytochemical and Pharmacological Screening

Stefanescu, Ruxandra; Zold, Eszter Laczko; Mare, Anca; Esianu, Sigrid; Grama, Izabela; Negroiu, Ancuta; Vari, Camil

Ruxandra Stefanescu, Eszter Laczko Zold, Anca Mare, Sigrid Esianu, Izabela Grama, Ancuta Negroiu, Camil Vari

Risks and Benefits Associated with Tribulus terrestris Products Assessed by Phytochemical and Pharmacological Screening

Abstract:

Recommendations of products with Tribulus terrestris as anabolic enhancers are based on empirical data. Exposure, especially of athletes, is very high, being among the most widely used nutritional supplements. Consumption of products containing Tribulus terrestris extracts has increased rapidly in the past few years due to the high content of sterol saponosides, compounds with presumed anabolic properties. Because of this upward surge, their efficacy and/or their safety are more and more often questioned. Commercialized dietary supplements, are often mislabelled, adulterated, or contaminated, therefore an evaluation of benefit/risk balance should always be conducted. Our study aimed to analyse an herbal drug and a food supplement frequently encountered on the market. Total polyphenolic and total saponosides content were determined. Inductively coupled plasma atomic emission spectrometry (ICP-AES) was used to determine mineral element content of Tribulus terrestris products. Antioxidant and antimicrobial activities were assayed. The extract obtained with the herbal drug had no antibacterial effect. The extract from the capsules, however, was active against all tested strains with higher activity against Methicillin-resistant Staphylococcus aureus and Escherichia coli (MIC = 0.78 mg/mL). Trace elements were quantified, and dose-related risks were outlined, raising awareness regarding the aluminum and nickel content in the herbal drug.

Keywords:
Keywords: steroidal saponins; anabolic enhancer; food supplements

Issue: 2020, Volume 71, Issue 4

Pages: 416-423

Publication date: 2020/5/5

https://doi.org/10.37358/RC.20.4.8082

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
STEFANESCU, R., ZOLD, E.L., MARE, A., ESIANU, S., GRAMA, I., NEGROIU, A., VARI, C., Risks and Benefits Associated with Tribulus terrestris Products Assessed by Phytochemical and Pharmacological Screening, Rev. Chim., 71(4), 2020, 416-423.

Vancouver
Stefanescu R, Zold EL, Mare A, Esianu S, Grama I, Negroiu A, Vari C. Risks and Benefits Associated with Tribulus terrestris Products Assessed by Phytochemical and Pharmacological Screening. Rev. Chim.[internet]. 2020 Apr;71(4):416-423. Available from: https://doi.org/10.37358/RC.20.4.8082

APA 6th edition
Stefanescu, R., Zold, E.L., Mare, A., Esianu, S., Grama, I., Negroiu, A. & Vari, C. (2020). Risks and Benefits Associated with Tribulus terrestris Products Assessed by Phytochemical and Pharmacological Screening. Revista de Chimie, 71(4), 416-423. https://doi.org/10.37358/RC.20.4.8082

Harvard
Stefanescu, R., Zold, E.L., Mare, A., Esianu, S., Grama, I., Negroiu, A., Vari, C. (2020). 'Risks and Benefits Associated with Tribulus terrestris Products Assessed by Phytochemical and Pharmacological Screening', Revista de Chimie, 71(4), pp. 416-423. https://doi.org/10.37358/RC.20.4.8082

IEEE
R. Stefanescu, E.L. Zold, A. Mare, S. Esianu, I. Grama, A. Negroiu, C. Vari, "Risks and Benefits Associated with Tribulus terrestris Products Assessed by Phytochemical and Pharmacological Screening". Revista de Chimie, vol. 71, no. 4, pp. 416-423, 2020. [online]. https://doi.org/10.37358/RC.20.4.8082

Text
Ruxandra Stefanescu, Eszter Laczko Zold, Anca Mare, Sigrid Esianu, Izabela Grama, Ancuta Negroiu, Camil Vari,
Risks and Benefits Associated with Tribulus terrestris Products Assessed by Phytochemical and Pharmacological Screening,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 416-423,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8082.
(https://revistadechimie.ro/Articles.asp?ID=8082)
Keywords: Keywords: steroidal saponins; anabolic enhancer; food supplements

RIS
TY - JOUR
T1 - Risks and Benefits Associated with Tribulus terrestris Products Assessed by Phytochemical and Pharmacological Screening
A1 - Stefanescu, Ruxandra
A2 - Zold, Eszter Laczko
A3 - Mare, Anca
A4 - Esianu, Sigrid
A5 - Grama, Izabela
A6 - Negroiu, Ancuta
A7 - Vari, Camil
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 416
EP - 423
UR - https://doi.org/10.37358/RC.20.4.8082
KW - Keywords: steroidal saponins
KW - anabolic enhancer
KW - food supplements

ER -

BibTex
@article{RevCh2020P416,
author = {Stefanescu Ruxandra and Zold Eszter Laczko and Mare Anca and Esianu Sigrid and Grama Izabela and Negroiu Ancuta and Vari Camil},
title = {Risks and Benefits Associated with Tribulus terrestris Products Assessed by Phytochemical and Pharmacological Screening},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {416-423},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8082},
url = {https://revistadechimie.ro/Articles.asp?ID=8082}
}

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