Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes

Radulescu, Matilda; Utescu, Crinela; Borcan, Florin; Dumitrascu, Victor; Navolan, Dan; Pavel, Ioana Zinuca; Stoian, Dana

Matilda Radulescu, Crinela Utescu, Florin Borcan, Victor Dumitrascu, Dan Navolan, Ioana Zinuca Pavel, Dana Stoian

Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes

Abstract:

Levonorgestrel is the most widely used synthetic hormone due in particular to strong progestin and anti-ovulatory effects, without estrogenic effects, being also used in hormone supportive therapy and found in preclinical studies for the prevention / occurrence of malignant processes. In order to be able to eliminate the adverse effects but to benefit at the same time from the beneficial biological effects, the posibility of obtaining effective and safe biocompatible formulations is studied. In the present research silver nanoparticles loaded with lenorgestrel were obtained and were subsequently included in a liposomal transporter system. Physico-chemical characterizations showed good stability of the liposomal systems obtained and dimensions compatible with the biological environment. In vitro data conducted on breast cells (MCF 10A and MCF7) revealed a dose-dependent influence in terms of cell viability with no significant changes at low concentration of samples (0.1 μM), while higher concentration was associated with a decrease of the viable breast adenocarcinoma cells especially in the case of silver nanoparticles.

Keywords:
levonorgestrel; silver nanoparticles; liposomes; breast cells

Issue: 2020, Volume 71, Issue 4

Pages: 424-429

Publication date: 2020/5/5

https://doi.org/10.37358/RC.20.4.8083

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
RADULESCU, M., UTESCU, C., BORCAN, F., DUMITRASCU, V., NAVOLAN, D., PAVEL, I.Z., STOIAN, D., Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes, Rev. Chim., 71(4), 2020, 424-429.

Vancouver
Radulescu M, Utescu C, Borcan F, Dumitrascu V, Navolan D, Pavel IZ, Stoian D. Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes. Rev. Chim.[internet]. 2020 Apr;71(4):424-429. Available from: https://doi.org/10.37358/RC.20.4.8083

APA 6th edition
Radulescu, M., Utescu, C., Borcan, F., Dumitrascu, V., Navolan, D., Pavel, I.Z. & Stoian, D. (2020). Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes. Revista de Chimie, 71(4), 424-429. https://doi.org/10.37358/RC.20.4.8083

Harvard
Radulescu, M., Utescu, C., Borcan, F., Dumitrascu, V., Navolan, D., Pavel, I.Z., Stoian, D. (2020). 'Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes', Revista de Chimie, 71(4), pp. 424-429. https://doi.org/10.37358/RC.20.4.8083

IEEE
M. Radulescu, C. Utescu, F. Borcan, V. Dumitrascu, D. Navolan, I.Z. Pavel, D. Stoian, "Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes". Revista de Chimie, vol. 71, no. 4, pp. 424-429, 2020. [online]. https://doi.org/10.37358/RC.20.4.8083

Text
Matilda Radulescu, Crinela Utescu, Florin Borcan, Victor Dumitrascu, Dan Navolan, Ioana Zinuca Pavel, Dana Stoian,
Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 424-429,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8083.
(https://revistadechimie.ro/Articles.asp?ID=8083)
Keywords: levonorgestrel; silver nanoparticles; liposomes; breast cells

RIS
TY - JOUR
T1 - Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes
A1 - Radulescu, Matilda
A2 - Utescu, Crinela
A3 - Borcan, Florin
A4 - Dumitrascu, Victor
A5 - Navolan, Dan
A6 - Pavel, Ioana Zinuca
A7 - Stoian, Dana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 424
EP - 429
UR - https://doi.org/10.37358/RC.20.4.8083
KW - levonorgestrel
KW - silver nanoparticles
KW - liposomes
KW - breast cells
ER -

BibTex
@article{RevCh2020P424,
author = {Radulescu Matilda and Utescu Crinela and Borcan Florin and Dumitrascu Victor and Navolan Dan and Pavel Ioana Zinuca and Stoian Dana},
title = {Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {424-429},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8083},
url = {https://revistadechimie.ro/Articles.asp?ID=8083}
}

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