Mihaela Paula Toader, Madalina Mocanu, Stefan Toader, Roxana Irina Iancu, Tatiana Taranu
Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus
Abstract:
Tacrolimus, a macrolide with immunosuppressive properties through the inhibition of T-lymphocyte activation, was approved as a second line topical treatment for atopic dermatitis, but has been largely used with beneficial effects in other dermatological conditions that involve a disregulation of the cellular immune response. Oral lichen planus is a T-cell-mediated autoimmune disease in which autocytotoxic CD8+ T cells trigger apoptosis of oral epithelial cells. Our study aimed to analyze the clinical efficacy of tacrolimus 0.03% and 0.1% in orabase as monotherapy on oral erosive lesions of lichen planus, in a group of 20 patients consulted in the Dermatology Clinic of the University C.F. Hospital Iasi during a period of five years. Our results show total or partial remission of oral erosive lesions in most patients at 3 months follow-up. However, after treatment discontinuation relapses are common, which is why intermittent use of topical tacrolimus is needed for longer periods to prevent recurrences. Further large scale studies are necessary to establish efficacy and safety profile of prolonged use of tacrolimus on mucosal membranes, as well as the most appropriate vehicle and concentration.
Cite this article as: TOADER, M.P., MOCANU, M., TOADER, S., IANCU, R.I., TARANU, T., Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus, Rev. Chim., 71(4), 2020, 438-445.
Vancouver Toader MP, Mocanu M, Toader S, Iancu RI, Taranu T. Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus. Rev. Chim.[internet]. 2020 Apr;71(4):438-445. Available from: https://doi.org/10.37358/RC.20.4.8085
APA 6th edition Toader, M.P., Mocanu, M., Toader, S., Iancu, R.I. & Taranu, T. (2020). Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus. Revista de Chimie, 71(4), 438-445. https://doi.org/10.37358/RC.20.4.8085
Harvard Toader, M.P., Mocanu, M., Toader, S., Iancu, R.I., Taranu, T. (2020). 'Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus', Revista de Chimie, 71(4), pp. 438-445. https://doi.org/10.37358/RC.20.4.8085
IEEE M.P. Toader, M. Mocanu, S. Toader, R.I. Iancu, T. Taranu, "Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus". Revista de Chimie, vol. 71, no. 4, pp. 438-445, 2020. [online]. https://doi.org/10.37358/RC.20.4.8085
Text Mihaela Paula Toader, Madalina Mocanu, Stefan Toader, Roxana Irina Iancu, Tatiana Taranu, Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus, Revista de Chimie, Volume 71, Issue 4, 2020, Pages 438-445, ISSN 2668-8212, https://doi.org/10.37358/RC.20.4.8085. (https://revistadechimie.ro/Articles.asp?ID=8085) Keywords: Tacrolimus; oral lichen planus; oral white lesions; oral erosions; premalignant oral lesions
RIS TY - JOUR T1 - Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus A1 - Toader, Mihaela Paula A2 - Mocanu, Madalina A3 - Toader, Stefan A4 - Iancu, Roxana Irina A5 - Taranu, Tatiana JF - Revista de Chimie JO - Rev. Chim. PB - Revista de Chimie SRL SN - 2668-8212 Y1 - 2020 VL - 71 IS - 4 SP - 438 EP - 445 UR - https://doi.org/10.37358/RC.20.4.8085 KW - Tacrolimus KW - oral lichen planus KW - oral white lesions KW - oral erosions KW - premalignant oral lesions ER -
BibTex @article{RevCh2020P438, author = {Toader Mihaela Paula and Mocanu Madalina and Toader Stefan and Iancu Roxana Irina and Taranu Tatiana}, title = {Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus}, journal = {Revista de Chimie}, volume = {71}, number = {4}, pages = {438-445}, year = {2020}, issn = {2668-8212}, doi = {https://doi.org/10.37358/RC.20.4.8085}, url = {https://revistadechimie.ro/Articles.asp?ID=8085} }
