ABOUT INDEXING BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER AUTHOR'S PAGE NEWS, EVENTS CONTACT
REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

REVISTA DE CHIMIE Latest Issue

LATEST ISSUE >>>

   Volume 75, 2024
   Volume 74, 2023
   Volume 73, 2022
   Volume 72, 2021
   Volume 71, 2020
   Volume 70, 2019
   Volume 69, 2018
   Volume 68, 2017
   Volume 67, 2016
   Volume 66, 2015
   Volume 65, 2014
   Volume 64, 2013
   Volume 63, 2012
   Volume 62, 2011
   Volume 61, 2010
   Volume 60, 2009
   Volume 59, 2008
   Volume 58, 2007
 
<<<< back

Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 4, 438-445

https://doi.org/10.37358/RC.20.4.8085

Mihaela Paula Toader, Madalina Mocanu, Stefan Toader, Roxana Irina Iancu, Tatiana Taranu

Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus

Abstract:

Tacrolimus, a macrolide with immunosuppressive properties through the inhibition of T-lymphocyte activation, was approved as a second line topical treatment for atopic dermatitis, but has been largely used with beneficial effects in other dermatological conditions that involve a disregulation of the cellular immune response. Oral lichen planus is a T-cell-mediated autoimmune disease in which autocytotoxic CD8+ T cells trigger apoptosis of oral epithelial cells. Our study aimed to analyze the clinical efficacy of tacrolimus 0.03% and 0.1% in orabase as monotherapy on oral erosive lesions of lichen planus, in a group of 20 patients consulted in the Dermatology Clinic of the University C.F. Hospital Iasi during a period of five years. Our results show total or partial remission of oral erosive lesions in most patients at 3 months follow-up. However, after treatment discontinuation relapses are common, which is why intermittent use of topical tacrolimus is needed for longer periods to prevent recurrences. Further large scale studies are necessary to establish efficacy and safety profile of prolonged use of tacrolimus on mucosal membranes, as well as the most appropriate vehicle and concentration.
Keywords:
Tacrolimus; oral lichen planus; oral white lesions; oral erosions; premalignant oral lesions

Issue: 2020, Volume 71, Issue 4
Pages: 438-445
Publication date: 2020/5/5
https://doi.org/10.37358/RC.20.4.8085
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
TOADER, M.P., MOCANU, M., TOADER, S., IANCU, R.I., TARANU, T., Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus, Rev. Chim., 71(4), 2020, 438-445.

Vancouver
Toader MP, Mocanu M, Toader S, Iancu RI, Taranu T. Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus. Rev. Chim.[internet]. 2020 Apr;71(4):438-445. Available from: https://doi.org/10.37358/RC.20.4.8085


APA 6th edition
Toader, M.P., Mocanu, M., Toader, S., Iancu, R.I. & Taranu, T. (2020). Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus. Revista de Chimie, 71(4), 438-445. https://doi.org/10.37358/RC.20.4.8085


Harvard
Toader, M.P., Mocanu, M., Toader, S., Iancu, R.I., Taranu, T. (2020). 'Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus', Revista de Chimie, 71(4), pp. 438-445. https://doi.org/10.37358/RC.20.4.8085


IEEE
M.P. Toader, M. Mocanu, S. Toader, R.I. Iancu, T. Taranu, "Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus". Revista de Chimie, vol. 71, no. 4, pp. 438-445, 2020. [online]. https://doi.org/10.37358/RC.20.4.8085


Text
Mihaela Paula Toader, Madalina Mocanu, Stefan Toader, Roxana Irina Iancu, Tatiana Taranu,
Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 438-445,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8085.
(https://revistadechimie.ro/Articles.asp?ID=8085)
Keywords: Tacrolimus; oral lichen planus; oral white lesions; oral erosions; premalignant oral lesions


RIS
TY - JOUR
T1 - Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus
A1 - Toader, Mihaela Paula
A2 - Mocanu, Madalina
A3 - Toader, Stefan
A4 - Iancu, Roxana Irina
A5 - Taranu, Tatiana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 438
EP - 445
UR - https://doi.org/10.37358/RC.20.4.8085
KW - Tacrolimus
KW - oral lichen planus
KW - oral white lesions
KW - oral erosions
KW - premalignant oral lesions
ER -


BibTex
@article{RevCh2020P438,
author = {Toader Mihaela Paula and Mocanu Madalina and Toader Stefan and Iancu Roxana Irina and Taranu Tatiana},
title = {Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {438-445},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8085},
url = {https://revistadechimie.ro/Articles.asp?ID=8085}
}
 
<<<< back
 
PUBLISHING SECTION
Author Guidelines
 * Paper Drafting
 * Paper Template
 * Ethical Statement
 * Paper Submission
Ghidul Autorului (ro)
Submit Paper
Author's Page
Publishing Ethics
Peer Review Process
Open Access & Archiving Policy
 Search Authors
 LATEST NEWS
REvista de Chimie NUMAR OMAGIAL PETRU PONI.. detalii
REvista de Chimie Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
dictionar English-Romanian Dictionary for Mechanical Engineering
(download pdf)
  News, Events
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License
 Conferences of Contemporary
 Chemistry
 Biblioteca Chimiei
 Materiale Plastice