Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus

Toader, Mihaela Paula; Mocanu, Madalina; Toader, Stefan; Iancu, Roxana Irina; Taranu, Tatiana

Mihaela Paula Toader, Madalina Mocanu, Stefan Toader, Roxana Irina Iancu, Tatiana Taranu

Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus

Abstract:

Tacrolimus, a macrolide with immunosuppressive properties through the inhibition of T-lymphocyte activation, was approved as a second line topical treatment for atopic dermatitis, but has been largely used with beneficial effects in other dermatological conditions that involve a disregulation of the cellular immune response. Oral lichen planus is a T-cell-mediated autoimmune disease in which autocytotoxic CD8+ T cells trigger apoptosis of oral epithelial cells. Our study aimed to analyze the clinical efficacy of tacrolimus 0.03% and 0.1% in orabase as monotherapy on oral erosive lesions of lichen planus, in a group of 20 patients consulted in the Dermatology Clinic of the University C.F. Hospital Iasi during a period of five years. Our results show total or partial remission of oral erosive lesions in most patients at 3 months follow-up. However, after treatment discontinuation relapses are common, which is why intermittent use of topical tacrolimus is needed for longer periods to prevent recurrences. Further large scale studies are necessary to establish efficacy and safety profile of prolonged use of tacrolimus on mucosal membranes, as well as the most appropriate vehicle and concentration.

Keywords:
Tacrolimus; oral lichen planus; oral white lesions; oral erosions; premalignant oral lesions

Issue: 2020, Volume 71, Issue 4

Pages: 438-445

Publication date: 2020/5/5

https://doi.org/10.37358/RC.20.4.8085

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TOADER, M.P., MOCANU, M., TOADER, S., IANCU, R.I., TARANU, T., Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus, Rev. Chim., 71(4), 2020, 438-445.

Vancouver
Toader MP, Mocanu M, Toader S, Iancu RI, Taranu T. Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus. Rev. Chim.[internet]. 2020 Apr;71(4):438-445. Available from: https://doi.org/10.37358/RC.20.4.8085

APA 6th edition
Toader, M.P., Mocanu, M., Toader, S., Iancu, R.I. & Taranu, T. (2020). Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus. Revista de Chimie, 71(4), 438-445. https://doi.org/10.37358/RC.20.4.8085

Harvard
Toader, M.P., Mocanu, M., Toader, S., Iancu, R.I., Taranu, T. (2020). 'Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus', Revista de Chimie, 71(4), pp. 438-445. https://doi.org/10.37358/RC.20.4.8085

IEEE
M.P. Toader, M. Mocanu, S. Toader, R.I. Iancu, T. Taranu, "Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus". Revista de Chimie, vol. 71, no. 4, pp. 438-445, 2020. [online]. https://doi.org/10.37358/RC.20.4.8085

Text
Mihaela Paula Toader, Madalina Mocanu, Stefan Toader, Roxana Irina Iancu, Tatiana Taranu,
Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 438-445,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8085.
(https://revistadechimie.ro/Articles.asp?ID=8085)
Keywords: Tacrolimus; oral lichen planus; oral white lesions; oral erosions; premalignant oral lesions

RIS
TY - JOUR
T1 - Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus
A1 - Toader, Mihaela Paula
A2 - Mocanu, Madalina
A3 - Toader, Stefan
A4 - Iancu, Roxana Irina
A5 - Taranu, Tatiana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 438
EP - 445
UR - https://doi.org/10.37358/RC.20.4.8085
KW - Tacrolimus
KW - oral lichen planus
KW - oral white lesions
KW - oral erosions
KW - premalignant oral lesions
ER -

BibTex
@article{RevCh2020P438,
author = {Toader Mihaela Paula and Mocanu Madalina and Toader Stefan and Iancu Roxana Irina and Taranu Tatiana},
title = {Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {438-445},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8085},
url = {https://revistadechimie.ro/Articles.asp?ID=8085}
}

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