Production of Reactive Oxygen Species, Unbalanced by Endogenous Antioxidant Capture Mechanisms Monitored in Surgically Treated Breast Cancer

Rusu-Moldovan, Alina Oana; Gruia, Maria Iuliana; Mirza, Camelia-Manuela; Mihu, Dan

Alina Oana Rusu-Moldovan, Maria Iuliana Gruia, Camelia-Manuela Mirza, Dan Mihu

Production of Reactive Oxygen Species, Unbalanced by Endogenous Antioxidant Capture Mechanisms Monitored in Surgically Treated Breast Cancer

Abstract:

Oxidative stress is defined as an imbalance between the production of oxygen reactive species (ROS) and their endogenous capacity of capturing them. Oxidative stress activates multiple effects generated by the non-specific growth of the ROS and by the decrease of antioxidant concentrations and neutralization mechanisms. The most accurate understanding of the mechanisms underlying oxidative stress and the deepening of its implications in different cancers has become very important in recent decades. Cancer cells are usually subjected to high levels of ROS, which continually activates the malignant phenotype by stimulating cell proliferation - by increasing the mitotic rate, angiogenesis, invasiveness and metastasis rates. The role of the ROS in the etiology and progression of breast cancer is in continuous processing. However, less attention has been paid to the development of redox-targeted breast cancer therapy strategies. Excess ROS production is detrimental for the survival and proliferation of neoplastic cells, through the oxidative-destructive mechanisms of biomolecules essential for life. This study departs from the hypothesis that the tumor is an inductive factor of oxidative stress, and an antioxidant treatment prior to surgery may influence the response to surgical treatment in breast cancer patients. This response is highlighted by determining certain essential compounds of the redox balance, after initiating the antioxidant therapy. Moreover, we have tried to assess the possible biochemical changes given by age, tumor size and asymmetry/laterality of the neoplasm in the investigated patients, and to determine the prognostic or predictive factors of these changes.

Keywords:
oxidative stress; antioxidants; breast cancer; laterality

Issue: 2020, Volume 71, Issue 4

Pages: 456-471

Publication date: 2020/5/5

https://doi.org/10.37358/RC.20.4.8088

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
RUSU-MOLDOVAN, A.O., GRUIA, M.I., MIRZA, C., MIHU, D., Production of Reactive Oxygen Species, Unbalanced by Endogenous Antioxidant Capture Mechanisms Monitored in Surgically Treated Breast Cancer, Rev. Chim., 71(4), 2020, 456-471.

Vancouver
Rusu-Moldovan AO, Gruia MI, Mirza C, Mihu D. Production of Reactive Oxygen Species, Unbalanced by Endogenous Antioxidant Capture Mechanisms Monitored in Surgically Treated Breast Cancer. Rev. Chim.[internet]. 2020 Apr;71(4):456-471. Available from: https://doi.org/10.37358/RC.20.4.8088

APA 6th edition
Rusu-Moldovan, A.O., Gruia, M.I., Mirza, C. & Mihu, D. (2020). Production of Reactive Oxygen Species, Unbalanced by Endogenous Antioxidant Capture Mechanisms Monitored in Surgically Treated Breast Cancer. Revista de Chimie, 71(4), 456-471. https://doi.org/10.37358/RC.20.4.8088

Harvard
Rusu-Moldovan, A.O., Gruia, M.I., Mirza, C., Mihu, D. (2020). 'Production of Reactive Oxygen Species, Unbalanced by Endogenous Antioxidant Capture Mechanisms Monitored in Surgically Treated Breast Cancer', Revista de Chimie, 71(4), pp. 456-471. https://doi.org/10.37358/RC.20.4.8088

IEEE
A.O. Rusu-Moldovan, M.I. Gruia, C. Mirza, D. Mihu, "Production of Reactive Oxygen Species, Unbalanced by Endogenous Antioxidant Capture Mechanisms Monitored in Surgically Treated Breast Cancer". Revista de Chimie, vol. 71, no. 4, pp. 456-471, 2020. [online]. https://doi.org/10.37358/RC.20.4.8088

Text
Alina Oana Rusu-Moldovan, Maria Iuliana Gruia, Camelia-Manuela Mirza, Dan Mihu,
Production of Reactive Oxygen Species, Unbalanced by Endogenous Antioxidant Capture Mechanisms Monitored in Surgically Treated Breast Cancer,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 456-471,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8088.
(https://revistadechimie.ro/Articles.asp?ID=8088)
Keywords: oxidative stress; antioxidants; breast cancer; laterality

RIS
TY - JOUR
T1 - Production of Reactive Oxygen Species, Unbalanced by Endogenous Antioxidant Capture Mechanisms Monitored in Surgically Treated Breast Cancer
A1 - Rusu-Moldovan, Alina Oana
A2 - Gruia, Maria Iuliana
A3 - Mirza, Camelia-Manuela
A4 - Mihu, Dan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 456
EP - 471
UR - https://doi.org/10.37358/RC.20.4.8088
KW - oxidative stress
KW - antioxidants
KW - breast cancer
KW - laterality
ER -

BibTex
@article{RevCh2020P456,
author = {Rusu-Moldovan Alina Oana and Gruia Maria Iuliana and Mirza Camelia-Manuela and Mihu Dan},
title = {Production of Reactive Oxygen Species, Unbalanced by Endogenous Antioxidant Capture Mechanisms Monitored in Surgically Treated Breast Cancer},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {456-471},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8088},
url = {https://revistadechimie.ro/Articles.asp?ID=8088}
}

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