Combined Treatment with Tenofovir (C9H14N5O4P), Emtricitabine (C8H10FN3O3S) and Efavirenz (C14H9ClF3NO2)  in Multiple Spleen Abscesses with Bacterial and Fungal Etiology in HIV Infected Patients

Tirnea, Livius; Belei, Oana; Tomescu, Mirela; Malita, Daniel; Vlad, Daliborca Cristina; Mosoarca, Roxana; Marincu, Iosif

Livius Tirnea, Oana Belei, Mirela Tomescu, Daniel Malita, Daliborca Cristina Vlad, Roxana Mosoarca, Iosif Marincu

Combined Treatment with Tenofovir (C9H14N5O4P), Emtricitabine (C8H10FN3O3S) and Efavirenz (C14H9ClF3NO2) in Multiple Spleen Abscesses with Bacterial and Fungal Etiology in HIV Infected Patients

Abstract:

Patients with human immunodeficiency virus (HIV) infection represent a risk group for developing spleen abscesses. The paper presents a short review and case illustration, describing the characteristics and underling treatment of HIV-infected patients with infectious comorbidities. There are few reports in literature of multiple spleen abscesses with double, microbial and fungal etiology in HIV-infected patients. A 35 years old male patient was referred to the Infectious Diseases Clinic with prolonged fever. In the last 2 years he had worked as a waiter and had multiple unprotected sexual contacts. The physical examination showed: fever, tongue and pharynx with Candida albicans deposits, enlarged cervical, submandibular, axillar, inguinal lymph nodes and splenomegaly. Biological tests including HIV antibodies (Ab) ELISA, CD4, HIV Western blot test, cultures and paraclinical investigations-abdominal ultrasonography and computed tomography were performed. There was a significant inflammatory response, HIV Ab were positive, CD4 cells=17/µL and Western blot HIV test was positive. Abdominal ultrasonography showed: splenomegaly with 3 hypoechogenic round images (13-17mm) at the superior pole, in the hilum and inferior pole. HIV infection stage C3 with oropharyngeal candidiasis and multiple splenic abscesses were diagnosed. After 6 weeks of antibiotic and antifungal therapy total splenectomy was performed. The cultures from splenic abscess contents revealed Acinetobacter baumannii and Cryptococcus neoformans. Under appropriate antibiotic and antifungal treatment, the postoperatory evolution was favorable.

Keywords:
antibiotic; antifungal therapy; spleen abscesses

Issue: 2020, Volume 71, Issue 4

Pages: 480-487

Publication date: 2020/5/5

https://doi.org/10.37358/RC.20.4.8090

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TIRNEA, L., BELEI, O., TOMESCU, M., MALITA, D., VLAD, D.C., MOSOARCA, R., MARINCU, I., Combined Treatment with Tenofovir (C9H14N5O4P), Emtricitabine (C8H10FN3O3S) and Efavirenz (C14H9ClF3NO2) in Multiple Spleen Abscesses with Bacterial and Fungal Etiology in HIV Infected Patients, Rev. Chim., 71(4), 2020, 480-487.

Vancouver
Tirnea L, Belei O, Tomescu M, Malita D, Vlad DC, Mosoarca R, Marincu I. Combined Treatment with Tenofovir (C9H14N5O4P), Emtricitabine (C8H10FN3O3S) and Efavirenz (C14H9ClF3NO2) in Multiple Spleen Abscesses with Bacterial and Fungal Etiology in HIV Infected Patients. Rev. Chim.[internet]. 2020 Apr;71(4):480-487. Available from: https://doi.org/10.37358/RC.20.4.8090

APA 6th edition
Tirnea, L., Belei, O., Tomescu, M., Malita, D., Vlad, D.C., Mosoarca, R. & Marincu, I. (2020). Combined Treatment with Tenofovir (C9H14N5O4P), Emtricitabine (C8H10FN3O3S) and Efavirenz (C14H9ClF3NO2) in Multiple Spleen Abscesses with Bacterial and Fungal Etiology in HIV Infected Patients. Revista de Chimie, 71(4), 480-487. https://doi.org/10.37358/RC.20.4.8090

Harvard
Tirnea, L., Belei, O., Tomescu, M., Malita, D., Vlad, D.C., Mosoarca, R., Marincu, I. (2020). 'Combined Treatment with Tenofovir (C9H14N5O4P), Emtricitabine (C8H10FN3O3S) and Efavirenz (C14H9ClF3NO2) in Multiple Spleen Abscesses with Bacterial and Fungal Etiology in HIV Infected Patients', Revista de Chimie, 71(4), pp. 480-487. https://doi.org/10.37358/RC.20.4.8090

IEEE
L. Tirnea, O. Belei, M. Tomescu, D. Malita, D.C. Vlad, R. Mosoarca, I. Marincu, "Combined Treatment with Tenofovir (C9H14N5O4P), Emtricitabine (C8H10FN3O3S) and Efavirenz (C14H9ClF3NO2) in Multiple Spleen Abscesses with Bacterial and Fungal Etiology in HIV Infected Patients". Revista de Chimie, vol. 71, no. 4, pp. 480-487, 2020. [online]. https://doi.org/10.37358/RC.20.4.8090

Text
Livius Tirnea, Oana Belei, Mirela Tomescu, Daniel Malita, Daliborca Cristina Vlad, Roxana Mosoarca, Iosif Marincu,
Combined Treatment with Tenofovir (C9H14N5O4P), Emtricitabine (C8H10FN3O3S) and Efavirenz (C14H9ClF3NO2) in Multiple Spleen Abscesses with Bacterial and Fungal Etiology in HIV Infected Patients,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 480-487,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8090.
(https://revistadechimie.ro/Articles.asp?ID=8090)
Keywords: antibiotic; antifungal therapy; spleen abscesses

RIS
TY - JOUR
T1 - Combined Treatment with Tenofovir (C9H14N5O4P), Emtricitabine (C8H10FN3O3S) and Efavirenz (C14H9ClF3NO2) in Multiple Spleen Abscesses with Bacterial and Fungal Etiology in HIV Infected Patients
A1 - Tirnea, Livius
A2 - Belei, Oana
A3 - Tomescu, Mirela
A4 - Malita, Daniel
A5 - Vlad, Daliborca Cristina
A6 - Mosoarca, Roxana
A7 - Marincu, Iosif
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 480
EP - 487
UR - https://doi.org/10.37358/RC.20.4.8090
KW - antibiotic
KW - antifungal therapy
KW - spleen abscesses
ER -

BibTex
@article{RevCh2020P480,
author = {Tirnea Livius and Belei Oana and Tomescu Mirela and Malita Daniel and Vlad Daliborca Cristina and Mosoarca Roxana and Marincu Iosif},
title = {Combined Treatment with Tenofovir (C9H14N5O4P), Emtricitabine (C8H10FN3O3S) and Efavirenz (C14H9ClF3NO2) in Multiple Spleen Abscesses with Bacterial and Fungal Etiology in HIV Infected Patients},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {480-487},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8090},
url = {https://revistadechimie.ro/Articles.asp?ID=8090}
}

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