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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 5, 1-16

https://doi.org/10.37358/RC.20.5.8107

Invited article review

Claudiu T. Supuran

A Simple Yet Multifaceted Enzyme

Abstract:

Carbonic anhydrases (CAs) are involved in many physiological and pathological .events in organisms all over the phylogenetic tree. Over the last three decades I was involved in unravelling the biochemical basic phenomena connected to these enzymes and in drug design of modulators of their activity (inhibitors and activators). The various approaches I developed were applied to many types of such enzymes and allowed the discovery of many classes of highly isoform-selective inhibitors. This afforded new applications of the inhibitors for the management of hypoxic tumors, neuropathic pain, cerebral ischemia, arthritis, degenerative disorders apart the classical ones connected with these drugs (diuretics, antiglaucoma, antiepileptic and antiobesity action). The study of CA activators showed that these enzymes may represent a crucial family of new targets for improving cognition as well as in therapeutic areas, such as phobias, obsessive-compulsive disorder, generalized anxiety, and post-traumatic stress disorders, for which few efficient therapies are available.
Keywords:
carbonic anhydrase; inhibition mechanism; inhibitor; activator; tail approach; anticancer drug; diuretic; neuropathic pain; neurodegeneration; memory therapy

Issue: 2020, Volume 71, Issue 5
Pages: 1-16
Publication date: 2020/5/29
https://doi.org/10.37358/RC.20.5.8107
Article type: Invited article review
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
SUPURAN, C.T., A Simple Yet Multifaceted Enzyme, Rev. Chim., 71(5), 2020, 1-16.

Vancouver
Supuran CT. A Simple Yet Multifaceted Enzyme. Rev. Chim.[internet]. 2020 May;71(5):1-16. Available from: https://doi.org/10.37358/RC.20.5.8107


APA 6th edition
Supuran, C.T., (2020). A Simple Yet Multifaceted Enzyme. Revista de Chimie, 71(5), 1-16. https://doi.org/10.37358/RC.20.5.8107


Harvard
Supuran, C.T., (2020). 'A Simple Yet Multifaceted Enzyme', Revista de Chimie, 71(5), pp. 1-16. https://doi.org/10.37358/RC.20.5.8107


IEEE
C.T. Supuran, "A Simple Yet Multifaceted Enzyme". Revista de Chimie, vol. 71, no. 5, pp. 1-16, 2020. [online]. https://doi.org/10.37358/RC.20.5.8107


Text
Claudiu T. Supuran,
A Simple Yet Multifaceted Enzyme,
Revista de Chimie,
Volume 71, Issue 5,
2020,
Pages 1-16,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.5.8107.
(https://revistadechimie.ro/Articles.asp?ID=8107)
Keywords: carbonic anhydrase; inhibition mechanism; inhibitor; activator; tail approach; anticancer drug; diuretic; neuropathic pain; neurodegeneration; memory therapy


RIS
TY - JOUR
T1 - A Simple Yet Multifaceted Enzyme
A1 - Supuran, Claudiu T.
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 5
SP - 1
EP - 16
UR - https://doi.org/10.37358/RC.20.5.8107
KW - carbonic anhydrase; inhibition mechanism; inhibitor; activator; tail approach; anticancer drug; diuretic; neuropathic pain; neurodegeneration; memory therapy
ER -


BibTex
@article{RevCh2020P1,
author = {Supuran Claudiu T.},
title = {A Simple Yet Multifaceted Enzyme},
journal = {Revista de Chimie},
volume = {71},
number = {5},
pages = {1-16},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.5.8107},
url = {https://revistadechimie.ro/Articles.asp?ID=8107}
}
 
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