Short and Improved Synthesis of Cytotoxic Homodimers with an Isoquinoline Structure

Meza, Paulina; Vaccaro, Silvana; Faundes, Judith; Segura, Rodrigo; Ibacache, Juana Andrea

Paulina Meza, Silvana Vaccaro, Judith Faundes, Rodrigo Segura, Juana Andrea Ibacache

Short and Improved Synthesis of Cytotoxic Homodimers with an Isoquinoline Structure

Abstract:

The syntheses of cytotoxic homodimers 5, 7-10 are described. Compounds 5, 7-10 were cleanly and efficiently obtained by microwave activation. A thorough study concerning oxidative reaction of diamines and isoquinolinequinones, under ultrasound (US) and microwave (MW) irradiation is presented. Under MW irradiation the yields are higher, the amount of precursor quinone used decreases substantially, the reaction time decreases considerably (from hours to minutes) in respect to previously reported methodology.

Keywords:
Homodımers; Isoquınolınequınones; Mıcrowave; Ultrasound

Issue: 2020, Volume 71, Issue 5

Pages: 58-64

Publication date: 2020/5/29

https://doi.org/10.37358/RC.20.5.8113

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MEZA, P., VACCARO, S., FAUNDES, J., SEGURA, R., IBACACHE, J.A., Short and Improved Synthesis of Cytotoxic Homodimers with an Isoquinoline Structure, Rev. Chim., 71(5), 2020, 58-64.

Vancouver
Meza P, Vaccaro S, Faundes J, Segura R, Ibacache JA. Short and Improved Synthesis of Cytotoxic Homodimers with an Isoquinoline Structure. Rev. Chim.[internet]. 2020 May;71(5):58-64. Available from: https://doi.org/10.37358/RC.20.5.8113

APA 6th edition
Meza, P., Vaccaro, S., Faundes, J., Segura, R. & Ibacache, J.A. (2020). Short and Improved Synthesis of Cytotoxic Homodimers with an Isoquinoline Structure. Revista de Chimie, 71(5), 58-64. https://doi.org/10.37358/RC.20.5.8113

Harvard
Meza, P., Vaccaro, S., Faundes, J., Segura, R., Ibacache, J.A. (2020). 'Short and Improved Synthesis of Cytotoxic Homodimers with an Isoquinoline Structure', Revista de Chimie, 71(5), pp. 58-64. https://doi.org/10.37358/RC.20.5.8113

IEEE
P. Meza, S. Vaccaro, J. Faundes, R. Segura, J.A. Ibacache, "Short and Improved Synthesis of Cytotoxic Homodimers with an Isoquinoline Structure". Revista de Chimie, vol. 71, no. 5, pp. 58-64, 2020. [online]. https://doi.org/10.37358/RC.20.5.8113

Text
Paulina Meza, Silvana Vaccaro, Judith Faundes, Rodrigo Segura, Juana Andrea Ibacache,
Short and Improved Synthesis of Cytotoxic Homodimers with an Isoquinoline Structure,
Revista de Chimie,
Volume 71, Issue 5,
2020,
Pages 58-64,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.5.8113.
(https://revistadechimie.ro/Articles.asp?ID=8113)
Keywords: Homodımers; Isoquınolınequınones; Mıcrowave; Ultrasound

RIS
TY - JOUR
T1 - Short and Improved Synthesis of Cytotoxic Homodimers with an Isoquinoline Structure
A1 - Meza, Paulina
A2 - Vaccaro, Silvana
A3 - Faundes, Judith
A4 - Segura, Rodrigo
A5 - Ibacache, Juana Andrea
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 5
SP - 58
EP - 64
UR - https://doi.org/10.37358/RC.20.5.8113
KW - Homodımers
KW - Isoquınolınequınones
KW - Mıcrowave
KW - Ultrasound
ER -

BibTex
@article{RevCh2020P58,
author = {Meza Paulina and Vaccaro Silvana and Faundes Judith and Segura Rodrigo and Ibacache Juana Andrea},
title = {Short and Improved Synthesis of Cytotoxic Homodimers with an Isoquinoline Structure},
journal = {Revista de Chimie},
volume = {71},
number = {5},
pages = {58-64},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.5.8113},
url = {https://revistadechimie.ro/Articles.asp?ID=8113}
}

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