Cyclodextrins Increase the Cytotoxicity of Curcumin Derivatives in Osteosarcoma Cell Culture

Stoica, Laura; Cotrutz, Elena Carmen; Onisor, Cristian; Tiutiuca, Carmen; Onofrei, Pavel; Grigore, Camelia Ana; Botez, Ana Emanuela; Grecu, Vasile Bogdan; Olinici, Doinita Temelie; Voinescu, Doina Carina; Stoica, Bogdan Alexandru

Laura Stoica, Elena Carmen Cotrutz, Cristian Onisor, Carmen Tiutiuca, Pavel Onofrei, Camelia Ana Grigore, Ana Emanuela Botez, Vasile Bogdan Grecu, Doinita Temelie Olinici, Doina Carina Voinescu, Bogdan Alexandru Stoica

Cyclodextrins Increase the Cytotoxicity of Curcumin Derivatives in Osteosarcoma Cell Culture

Abstract:

Cyclodextrins (CDs), a group of oligosaccharides formed by glucose units bound togetherin a ring, showed a promising ability to form supramolecular complexes with drug molecules and improved theirphysicochemical properties without any molecular modifications. On the other hand, a large number of synthetic curcumin derivatives showed promising anticancer results on malignant cell cultures in recent years. This study presents the advantages and limitations of CDs (potential enhancers of solubility and stability) when are used together with a series of curcumin complexes. All the CD-curcumin complex mixtures were tested as potential anticancer agents on a human osteosarcoma cell culture. A variant of beta-cyclodextrin (monochlorotriazinyl-β-cyclodextrin sodium salt) was found to exhibit the best results in terms of solubility and cytotoxicity enhancements. The results(expressed as inhibitory concentrations for 50 % cell viability - IC50) showed significant improvements for manganese and cooper curcumin complexes and had no effects for boron and thorium complexes.

Keywords:
cyclodextrins; solubility;curcumin complexes; anticancer effects

Issue: 2020, Volume 71, Issue 5

Pages: 150-156

Publication date: 2020/5/29

https://doi.org/10.37358/RC.20.5.8123

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
STOICA, L., COTRUTZ, E.C., ONISOR, C., TIUTIUCA, C., ONOFREI, P., GRIGORE, C.A., BOTEZ, A.E., GRECU, V.B., OLINICI, D.T., VOINESCU, D.C., STOICA, B.A., Cyclodextrins Increase the Cytotoxicity of Curcumin Derivatives in Osteosarcoma Cell Culture, Rev. Chim., 71(5), 2020, 150-156.

Vancouver
Stoica L, Cotrutz EC, Onisor C, Tiutiuca C, Onofrei P, Grigore CA, Botez AE, Grecu VB, Olinici DT, Voinescu DC, Stoica BA. Cyclodextrins Increase the Cytotoxicity of Curcumin Derivatives in Osteosarcoma Cell Culture. Rev. Chim.[internet]. 2020 May;71(5):150-156. Available from: https://doi.org/10.37358/RC.20.5.8123

APA 6th edition
Stoica, L., Cotrutz, E.C., Onisor, C., Tiutiuca, C., Onofrei, P., Grigore, C.A.,... Stoica, B.A. (2020). Cyclodextrins Increase the Cytotoxicity of Curcumin Derivatives in Osteosarcoma Cell Culture. Revista de Chimie, 71(5), 150-156. https://doi.org/10.37358/RC.20.5.8123

Harvard
Stoica, L., Cotrutz, E.C., Onisor, C., Tiutiuca, C., Onofrei, P., Grigore, C.A., Botez, A.E., Grecu, V.B., Olinici, D.T., Voinescu, D.C., Stoica, B.A. (2020). 'Cyclodextrins Increase the Cytotoxicity of Curcumin Derivatives in Osteosarcoma Cell Culture', Revista de Chimie, 71(5), pp. 150-156. https://doi.org/10.37358/RC.20.5.8123

IEEE
L. Stoica, E.C. Cotrutz, C. Onisor, C. Tiutiuca, P. Onofrei, C.A. Grigore, A.E. Botez, V.B. Grecu, D.T. Olinici, D.C. Voinescu, B.A. Stoica, "Cyclodextrins Increase the Cytotoxicity of Curcumin Derivatives in Osteosarcoma Cell Culture". Revista de Chimie, vol. 71, no. 5, pp. 150-156, 2020. [online]. https://doi.org/10.37358/RC.20.5.8123

Text
Laura Stoica, Elena Carmen Cotrutz, Cristian Onisor, Carmen Tiutiuca, Pavel Onofrei, Camelia Ana Grigore, Ana Emanuela Botez, Vasile Bogdan Grecu, Doinita Temelie Olinici, Doina Carina Voinescu, Bogdan Alexandru Stoica,
Cyclodextrins Increase the Cytotoxicity of Curcumin Derivatives in Osteosarcoma Cell Culture,
Revista de Chimie,
Volume 71, Issue 5,
2020,
Pages 150-156,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.5.8123.
(https://revistadechimie.ro/Articles.asp?ID=8123)
Keywords: cyclodextrins; solubility;curcumin complexes; anticancer effects

RIS
TY - JOUR
T1 - Cyclodextrins Increase the Cytotoxicity of Curcumin Derivatives in Osteosarcoma Cell Culture
A1 - Stoica, Laura
A2 - Cotrutz, Elena Carmen
A3 - Onisor, Cristian
A4 - Tiutiuca, Carmen
A5 - Onofrei, Pavel
A6 - Grigore, Camelia Ana
A7 - Botez, Ana Emanuela
A8 - Grecu, Vasile Bogdan
A9 - Olinici, Doinita Temelie
A10 - Voinescu, Doina Carina
A11 - Stoica, Bogdan Alexandru
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 5
SP - 150
EP - 156
UR - https://doi.org/10.37358/RC.20.5.8123
KW - cyclodextrins
KW - solubility
KW - curcumin complexes
KW - anticancer effects
ER -

BibTex
@article{RevCh2020P150,
author = {Stoica Laura and Cotrutz Elena Carmen and Onisor Cristian and Tiutiuca Carmen and Onofrei Pavel and Grigore Camelia Ana and Botez Ana Emanuela and Grecu Vasile Bogdan and Olinici Doinita Temelie and Voinescu Doina Carina and Stoica Bogdan Alexandru},
title = {Cyclodextrins Increase the Cytotoxicity of Curcumin Derivatives in Osteosarcoma Cell Culture},
journal = {Revista de Chimie},
volume = {71},
number = {5},
pages = {150-156},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.5.8123},
url = {https://revistadechimie.ro/Articles.asp?ID=8123}
}

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