Acute Phase Inflammatory Proteins, Gut Microbiota Dysbiosis and Severity of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

Ancusa, Oana-Elena; Georgescu, Doina; Iurciuc, Stela; Georgescu, Liviu-Andrei; Basa, Norina; Belei, Oana; Lighezan, Daniel

Oana-Elena Ancusa, Doina Georgescu, Stela Iurciuc, Liviu-Andrei Georgescu, Norina Basa, Oana Belei, Daniel Lighezan

Acute Phase Inflammatory Proteins, Gut Microbiota Dysbiosis and Severity of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

Abstract:

Since obesity and type 2 diabetes mellitus (DM) became almost pandemic, incidence and prevalence of associated nonalcoholic fatty liver disease (NAFLD) rose accordingly. Aim of the study was assessing whether there is a link between circulating C-reactive protein(CRP), gut microbiota dysbiosis and severity of liver disease in patients with NAFLD and confirmed type 2 DM. 50 patients diagnosed with type 2 DM were consecutively enrolled in this cross-sectional, pilot study, being evenly divided in two groups, as matched pairs, on the basis of presence or absence of NAFLD confirmed by abdominal and CT exam, after ruling out a lot of diseases and conditions. Patients underwent measurements of waist circumference, blood pressure (BP), body mass index (BMI) and thoroughly physical examination. Complete blood count (CBC), liver tests, CRP, fasting plasma glucose (FPG), low density lipoprotein(LDL) and high-density lipoprotein(HDL) cholesterol, triglycerides, creatinin and uric acid, micro proteinuria as well as stool microbiology were run, using standardized methods. Fatty liver index (FLI) was also calculated. Fibromax (BioPredictive) was performed in NAFLD (+) patients. NAFLD (+) group displayed significant differences of age and BMI, as well as lab biochemistry: ALT, GGT, LDL-cholesterol and triglycerides, CRP, microprotienuria and stool microbiology.. Strong positive correlation of CRP with gut dysbiosis (DB) severity, microproteinuria, as well as with nonalcoholic steatohepatitis (NASH) score, were observed. DB range correlated positively in NAFLD (+) group with age, BMI, BP, dyspepsia as well as with NASH scores. In conclusion patients with NAFLD and associated type 2 DM displayed a specific profile with significant differences of age, BMI, FLI, diabetic treatment, biochemistry and gut microbiological charts. Strong positive correlations between CRP, gut DB and NASH score suggest the possibility of link between inflammation, gut microbiota DB and severity of liver disease.

Keywords:
CRP; gut microbiota dysbiosis; NAFLD; type 2 DM

Issue: 2020, Volume 71, Issue 5

Pages: 290-298

Publication date: 2020/5/29

https://doi.org/10.37358/RC.20.5.8136

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ANCUSA, O., GEORGESCU, D., IURCIUC, S., GEORGESCU, L., BASA, N., BELEI, O., LIGHEZAN, D., Acute Phase Inflammatory Proteins, Gut Microbiota Dysbiosis and Severity of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus, Rev. Chim., 71(5), 2020, 290-298.

Vancouver
Ancusa O, Georgescu D, Iurciuc S, Georgescu L, Basa N, Belei O, Lighezan D. Acute Phase Inflammatory Proteins, Gut Microbiota Dysbiosis and Severity of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus. Rev. Chim.[internet]. 2020 May;71(5):290-298. Available from: https://doi.org/10.37358/RC.20.5.8136

APA 6th edition
Ancusa, O., Georgescu, D., Iurciuc, S., Georgescu, L., Basa, N., Belei, O. & Lighezan, D. (2020). Acute Phase Inflammatory Proteins, Gut Microbiota Dysbiosis and Severity of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus. Revista de Chimie, 71(5), 290-298. https://doi.org/10.37358/RC.20.5.8136

Harvard
Ancusa, O., Georgescu, D., Iurciuc, S., Georgescu, L., Basa, N., Belei, O., Lighezan, D. (2020). 'Acute Phase Inflammatory Proteins, Gut Microbiota Dysbiosis and Severity of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus', Revista de Chimie, 71(5), pp. 290-298. https://doi.org/10.37358/RC.20.5.8136

IEEE
O. Ancusa, D. Georgescu, S. Iurciuc, L. Georgescu, N. Basa, O. Belei, D. Lighezan, "Acute Phase Inflammatory Proteins, Gut Microbiota Dysbiosis and Severity of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus". Revista de Chimie, vol. 71, no. 5, pp. 290-298, 2020. [online]. https://doi.org/10.37358/RC.20.5.8136

Text
Oana-Elena Ancusa, Doina Georgescu, Stela Iurciuc, Liviu-Andrei Georgescu, Norina Basa, Oana Belei, Daniel Lighezan,
Acute Phase Inflammatory Proteins, Gut Microbiota Dysbiosis and Severity of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus,
Revista de Chimie,
Volume 71, Issue 5,
2020,
Pages 290-298,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.5.8136.
(https://revistadechimie.ro/Articles.asp?ID=8136)
Keywords: CRP; gut microbiota dysbiosis; NAFLD; type 2 DM

RIS
TY - JOUR
T1 - Acute Phase Inflammatory Proteins, Gut Microbiota Dysbiosis and Severity of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
A1 - Ancusa, Oana-Elena
A2 - Georgescu, Doina
A3 - Iurciuc, Stela
A4 - Georgescu, Liviu-Andrei
A5 - Basa, Norina
A6 - Belei, Oana
A7 - Lighezan, Daniel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 5
SP - 290
EP - 298
UR - https://doi.org/10.37358/RC.20.5.8136
KW - CRP
KW - gut microbiota dysbiosis
KW - NAFLD
KW - type 2 DM
ER -

BibTex
@article{RevCh2020P290,
author = {Ancusa Oana-Elena and Georgescu Doina and Iurciuc Stela and Georgescu Liviu-Andrei and Basa Norina and Belei Oana and Lighezan Daniel},
title = {Acute Phase Inflammatory Proteins, Gut Microbiota Dysbiosis and Severity of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus},
journal = {Revista de Chimie},
volume = {71},
number = {5},
pages = {290-298},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.5.8136},
url = {https://revistadechimie.ro/Articles.asp?ID=8136}
}

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