Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential

Focsa, Alin; Iacob, Andreea; Vasincu, Ioana; Constantin, Sandra; Andriescu, Loredana; Sava, Alexandru; Buron, Frederic; Routier, Sylvain; Apotrosoaei, Maria; Profire, Lenuta

Alin Focsa, Andreea Iacob, Ioana Vasincu, Sandra Constantin, Loredana Andriescu, Alexandru Sava, Frederic Buron, Sylvain Routier, Maria Apotrosoaei, Lenuta Profire

Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential

Abstract:

The aim of the study was to optimize the synthesis of diclofenac derivative with hydrazones structure in order to obtain higher yields and purity by variation of different parameters such as: ratio between reactants, solvent, catalyst, temperature, time of reaction and method used. The anti-inflammatory effects of diclofenac derivatives were evaluated using in vitro assays: albumin denaturation and erythrocyte membrane stability. The obtained results showed that the effect of the tested derivatives is increasing with the concentration, the best results being obtained at the concentration of 125 µg/mL (albumin denaturation assay), respectively 111.11 µg/mL (erythrocyte membrane stability assay). The most active compound was 4d which showed the highest inhibition effect on albumin denaturation and an appreciable effect on erythrocyte membrane stability, in comparation with diclofenac, used as drug reference.

Keywords:
diclofenac; hydrazone; optimization; anti-inflammatory effect

Issue: 2020, Volume 71, Issue 5

Pages: 305-314

Publication date: 2020/5/29

https://doi.org/10.37358/RC.20.5.8138

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
FOCSA, A., IACOB, A., VASINCU, I., CONSTANTIN, S., ANDRIESCU, L., SAVA, A., BURON, F., ROUTIER, S., APOTROSOAEI, M., PROFIRE, L., Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential, Rev. Chim., 71(5), 2020, 305-314.

Vancouver
Focsa A, Iacob A, Vasincu I, Constantin S, Andriescu L, Sava A, Buron F, Routier S, Apotrosoaei M, Profire L. Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential. Rev. Chim.[internet]. 2020 May;71(5):305-314. Available from: https://doi.org/10.37358/RC.20.5.8138

APA 6th edition
Focsa, A., Iacob, A., Vasincu, I., Constantin, S., Andriescu, L., Sava, A.,... Profire, L. (2020). Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential. Revista de Chimie, 71(5), 305-314. https://doi.org/10.37358/RC.20.5.8138

Harvard
Focsa, A., Iacob, A., Vasincu, I., Constantin, S., Andriescu, L., Sava, A., Buron, F., Routier, S., Apotrosoaei, M., Profire, L. (2020). 'Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential', Revista de Chimie, 71(5), pp. 305-314. https://doi.org/10.37358/RC.20.5.8138

IEEE
A. Focsa, A. Iacob, I. Vasincu, S. Constantin, L. Andriescu, A. Sava, F. Buron, S. Routier, M. Apotrosoaei, L. Profire, "Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential". Revista de Chimie, vol. 71, no. 5, pp. 305-314, 2020. [online]. https://doi.org/10.37358/RC.20.5.8138

Text
Alin Focsa, Andreea Iacob, Ioana Vasincu, Sandra Constantin, Loredana Andriescu, Alexandru Sava, Frederic Buron, Sylvain Routier, Maria Apotrosoaei, Lenuta Profire,
Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential,
Revista de Chimie,
Volume 71, Issue 5,
2020,
Pages 305-314,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.5.8138.
(https://revistadechimie.ro/Articles.asp?ID=8138)
Keywords: diclofenac; hydrazone; optimization; anti-inflammatory effect

RIS
TY - JOUR
T1 - Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential
A1 - Focsa, Alin
A2 - Iacob, Andreea
A3 - Vasincu, Ioana
A4 - Constantin, Sandra
A5 - Andriescu, Loredana
A6 - Sava, Alexandru
A7 - Buron, Frederic
A8 - Routier, Sylvain
A9 - Apotrosoaei, Maria
A10 - Profire, Lenuta
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 5
SP - 305
EP - 314
UR - https://doi.org/10.37358/RC.20.5.8138
KW - diclofenac
KW - hydrazone
KW - optimization
KW - anti-inflammatory effect
ER -

BibTex
@article{RevCh2020P305,
author = {Focsa Alin and Iacob Andreea and Vasincu Ioana and Constantin Sandra and Andriescu Loredana and Sava Alexandru and Buron Frederic and Routier Sylvain and Apotrosoaei Maria and Profire Lenuta},
title = {Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential},
journal = {Revista de Chimie},
volume = {71},
number = {5},
pages = {305-314},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.5.8138},
url = {https://revistadechimie.ro/Articles.asp?ID=8138}
}

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