Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy

Iancu, Roxana Irina; Toader, Paula Mihaela; Mocanu, Madalina; Mirestean, Camil Ciprian; Iancu, Dragos

Roxana Irina Iancu, Paula Mihaela Toader, Madalina Mocanu, Camil Ciprian Mirestean, Dragos Iancu

Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy

Abstract:

Blood platelets are pivotal cells in the process of hemostasis and thrombosis. In the majority of patients with severe liver disease, platelet function appeared defective. We determinate platelet adhesiveness, aggregability and MDA level, in rats with acute and chronic hepatopathy induced by CCl4 administration. Our data relieves that platelet functions are not only affected in chronic toxic affectation, but also in acute intoxication (p[0.05). Icosanoids production (expressed in MDA levels) are significantly decreased only in chronic CCl4 intoxication (p[0.001). Significant correlation appears between aggregability and MDA (r = -0.78) and adhesiveness and MDA (r = -0.57) in group C, with chronic CCl4 intoxication. The complexity of these platelet functions related to the hepatic disease is still a matter of debate and needs further investigation.

Keywords:
malondyaldehyde (MDA); platelets; liver; lipid peroxidation

Issue: 2020, Volume 71, Issue 5

Pages: 315-320

Publication date: 2020/5/29

https://doi.org/10.37358/RC.20.5.8139

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IANCU, R.I., TOADER, P.M., MOCANU, M., MIRESTEAN, C.C., IANCU, D., Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy, Rev. Chim., 71(5), 2020, 315-320.

Vancouver
Iancu RI, Toader PM, Mocanu M, Mirestean CC, Iancu D. Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy. Rev. Chim.[internet]. 2020 May;71(5):315-320. Available from: https://doi.org/10.37358/RC.20.5.8139

APA 6th edition
Iancu, R.I., Toader, P.M., Mocanu, M., Mirestean, C.C. & Iancu, D. (2020). Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy. Revista de Chimie, 71(5), 315-320. https://doi.org/10.37358/RC.20.5.8139

Harvard
Iancu, R.I., Toader, P.M., Mocanu, M., Mirestean, C.C., Iancu, D. (2020). 'Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy', Revista de Chimie, 71(5), pp. 315-320. https://doi.org/10.37358/RC.20.5.8139

IEEE
R.I. Iancu, P.M. Toader, M. Mocanu, C.C. Mirestean, D. Iancu, "Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy". Revista de Chimie, vol. 71, no. 5, pp. 315-320, 2020. [online]. https://doi.org/10.37358/RC.20.5.8139

Text
Roxana Irina Iancu, Paula Mihaela Toader, Madalina Mocanu, Camil Ciprian Mirestean, Dragos Iancu,
Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy,
Revista de Chimie,
Volume 71, Issue 5,
2020,
Pages 315-320,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.5.8139.
(https://revistadechimie.ro/Articles.asp?ID=8139)
Keywords: malondyaldehyde (MDA); platelets; liver; lipid peroxidation

RIS
TY - JOUR
T1 - Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy
A1 - Iancu, Roxana Irina
A2 - Toader, Paula Mihaela
A3 - Mocanu, Madalina
A4 - Mirestean, Camil Ciprian
A5 - Iancu, Dragos
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 5
SP - 315
EP - 320
UR - https://doi.org/10.37358/RC.20.5.8139
KW - malondyaldehyde (MDA)
KW - platelets
KW - liver
KW - lipid peroxidation
ER -

BibTex
@article{RevCh2020P315,
author = {Iancu Roxana Irina and Toader Paula Mihaela and Mocanu Madalina and Mirestean Camil Ciprian and Iancu Dragos},
title = {Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy},
journal = {Revista de Chimie},
volume = {71},
number = {5},
pages = {315-320},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.5.8139},
url = {https://revistadechimie.ro/Articles.asp?ID=8139}
}

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