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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 5, 347-354

https://doi.org/10.37358/RC.20.5.8143

Juan Carlos Martinez-Espinosa, Osvaldo Rodriguez-Villalon, Teodoro Cordova-Fraga, Eduardo Perez-Careta, Jose Rafael Guzman-Sepulveda, Laura Madrid-Molina, Rafael Guzman-Cabrera

Quantitative Pharmaceutical Analysis Based on the PCA of Raman Spectra

Abstract:

In the present work we examine the distribution of ciprofloxacin drug as an active ingredient in tablets samples from eight different laboratories. Additionally, control samples with different concentration were prepared for calibration. Raman spectra were recorded from all samples, including controls, and a principal component analysis (PCA) was implemented on them. The results of the PCA on control samples show that a clear discrimination among the different samples can be achieved and, more importantly, that the principal component of the Raman spectra has a well-defined, linear relation with the concentration of ciprofloxacin. Such a strong, statistically significant linear correlation obtained for the control samples constitutes our calibration for the quantitative analysis of commercial pharmaceutical compounds.
Keywords:
principal components analysis; Raman spectroscopy; ciprofloxacin; pharmaceutical compounds

Issue: 2020, Volume 71, Issue 5
Pages: 347-354
Publication date: 2020/5/29
https://doi.org/10.37358/RC.20.5.8143
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MARTINEZ-ESPINOSA, J.C., RODRIGUEZ-VILLALON, O., CORDOVA-FRAGA, T., PEREZ-CARETA, E., GUZMAN-SEPULVEDA, J.R., MADRID-MOLINA, L., GUZMAN-CABRERA, R., Quantitative Pharmaceutical Analysis Based on the PCA of Raman Spectra, Rev. Chim., 71(5), 2020, 347-354.

Vancouver
Martinez-Espinosa JC, Rodriguez-Villalon O, Cordova-Fraga T, Perez-Careta E, Guzman-Sepulveda JR, Madrid-Molina L, Guzman-Cabrera R. Quantitative Pharmaceutical Analysis Based on the PCA of Raman Spectra. Rev. Chim.[internet]. 2020 May;71(5):347-354. Available from: https://doi.org/10.37358/RC.20.5.8143


APA 6th edition
Martinez-Espinosa, J.C., Rodriguez-Villalon, O., Cordova-Fraga, T., Perez-Careta, E., Guzman-Sepulveda, J.R., Madrid-Molina, L. & Guzman-Cabrera, R. (2020). Quantitative Pharmaceutical Analysis Based on the PCA of Raman Spectra. Revista de Chimie, 71(5), 347-354. https://doi.org/10.37358/RC.20.5.8143


Harvard
Martinez-Espinosa, J.C., Rodriguez-Villalon, O., Cordova-Fraga, T., Perez-Careta, E., Guzman-Sepulveda, J.R., Madrid-Molina, L., Guzman-Cabrera, R. (2020). 'Quantitative Pharmaceutical Analysis Based on the PCA of Raman Spectra', Revista de Chimie, 71(5), pp. 347-354. https://doi.org/10.37358/RC.20.5.8143


IEEE
J.C. Martinez-Espinosa, O. Rodriguez-Villalon, T. Cordova-Fraga, E. Perez-Careta, J.R. Guzman-Sepulveda, L. Madrid-Molina, R. Guzman-Cabrera, "Quantitative Pharmaceutical Analysis Based on the PCA of Raman Spectra". Revista de Chimie, vol. 71, no. 5, pp. 347-354, 2020. [online]. https://doi.org/10.37358/RC.20.5.8143


Text
Juan Carlos Martinez-Espinosa, Osvaldo Rodriguez-Villalon, Teodoro Cordova-Fraga, Eduardo Perez-Careta, Jose Rafael Guzman-Sepulveda, Laura Madrid-Molina, Rafael Guzman-Cabrera,
Quantitative Pharmaceutical Analysis Based on the PCA of Raman Spectra,
Revista de Chimie,
Volume 71, Issue 5,
2020,
Pages 347-354,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.5.8143.
(https://revistadechimie.ro/Articles.asp?ID=8143)
Keywords: principal components analysis; Raman spectroscopy; ciprofloxacin; pharmaceutical compounds


RIS
TY - JOUR
T1 - Quantitative Pharmaceutical Analysis Based on the PCA of Raman Spectra
A1 - Martinez-Espinosa, Juan Carlos
A2 - Rodriguez-Villalon, Osvaldo
A3 - Cordova-Fraga, Teodoro
A4 - Perez-Careta, Eduardo
A5 - Guzman-Sepulveda, Jose Rafael
A6 - Madrid-Molina, Laura
A7 - Guzman-Cabrera, Rafael
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 5
SP - 347
EP - 354
UR - https://doi.org/10.37358/RC.20.5.8143
KW - principal components analysis
KW - Raman spectroscopy
KW - ciprofloxacin
KW - pharmaceutical compounds
ER -


BibTex
@article{RevCh2020P347,
author = {Martinez-Espinosa Juan Carlos and Rodriguez-Villalon Osvaldo and Cordova-Fraga Teodoro and Perez-Careta Eduardo and Guzman-Sepulveda Jose Rafael and Madrid-Molina Laura and Guzman-Cabrera Rafael},
title = {Quantitative Pharmaceutical Analysis Based on the PCA of Raman Spectra},
journal = {Revista de Chimie},
volume = {71},
number = {5},
pages = {347-354},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.5.8143},
url = {https://revistadechimie.ro/Articles.asp?ID=8143}
}
 
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