Proton-Pump Inhibitors in Adults and Pediatric Patients: Use and Abuse

Belei, Oana; Amaricai, Elena; Iacob, Emil Radu; Tirnea, Livius; Iacob, Daniela; Marginean, Otilia; Ancusa, Oana-Elena

Oana Belei, Elena Amaricai, Emil Radu Iacob, Livius Tirnea, Daniela Iacob, Otilia Marginean, Oana-Elena Ancusa

Proton-Pump Inhibitors in Adults and Pediatric Patients: Use and Abuse

Abstract:

Proton-Pump Inhibitors (PPIs) represent the major therapeutic tool of gastric acid-related disorders in adults and pediatric patients. The proton pump must be activated before the PPI is cleared from the circulation in order to effectively inhibit the H/K ATPase. This is related to time to reach maximum concentration, the absorption and elimination rate of the drug. All these features are modulated by age and genetics. Prolonged inhibition of gastric acid secretion may cause hypergastrinemia and enterochromaffin-like-cell hyperplasia, nutrients deficiency, necrotizing enterocolitis, atrophic gastritis, intestinal dysbiosis and digestive infections. These potential side effects have been described in adults, but pediatric studies are scarce. This review summarizes the pharmacodynamic features of PPIs and clarifies the side effects mechanisms of PPIs in children and adults.

Keywords:
proton-pump inhibitors; pharmacokinetic; side effects; dysbiosis

Issue: 2020, Volume 71, Issue 5

Pages: 414-426

Publication date: 2020/5/29

https://doi.org/10.37358/RC.20.5.8152

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BELEI, O., AMARICAI, E., IACOB, E.R., TIRNEA, L., IACOB, D., MARGINEAN, O., ANCUSA, O., Proton-Pump Inhibitors in Adults and Pediatric Patients: Use and Abuse, Rev. Chim., 71(5), 2020, 414-426.

Vancouver
Belei O, Amaricai E, Iacob ER, Tirnea L, Iacob D, Marginean O, Ancusa O. Proton-Pump Inhibitors in Adults and Pediatric Patients: Use and Abuse. Rev. Chim.[internet]. 2020 May;71(5):414-426. Available from: https://doi.org/10.37358/RC.20.5.8152

APA 6th edition
Belei, O., Amaricai, E., Iacob, E.R., Tirnea, L., Iacob, D., Marginean, O. & Ancusa, O. (2020). Proton-Pump Inhibitors in Adults and Pediatric Patients: Use and Abuse. Revista de Chimie, 71(5), 414-426. https://doi.org/10.37358/RC.20.5.8152

Harvard
Belei, O., Amaricai, E., Iacob, E.R., Tirnea, L., Iacob, D., Marginean, O., Ancusa, O. (2020). 'Proton-Pump Inhibitors in Adults and Pediatric Patients: Use and Abuse', Revista de Chimie, 71(5), pp. 414-426. https://doi.org/10.37358/RC.20.5.8152

IEEE
O. Belei, E. Amaricai, E.R. Iacob, L. Tirnea, D. Iacob, O. Marginean, O. Ancusa, "Proton-Pump Inhibitors in Adults and Pediatric Patients: Use and Abuse". Revista de Chimie, vol. 71, no. 5, pp. 414-426, 2020. [online]. https://doi.org/10.37358/RC.20.5.8152

Text
Oana Belei, Elena Amaricai, Emil Radu Iacob, Livius Tirnea, Daniela Iacob, Otilia Marginean, Oana-Elena Ancusa,
Proton-Pump Inhibitors in Adults and Pediatric Patients: Use and Abuse,
Revista de Chimie,
Volume 71, Issue 5,
2020,
Pages 414-426,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.5.8152.
(https://revistadechimie.ro/Articles.asp?ID=8152)
Keywords: proton-pump inhibitors; pharmacokinetic; side effects; dysbiosis

RIS
TY - JOUR
T1 - Proton-Pump Inhibitors in Adults and Pediatric Patients: Use and Abuse
A1 - Belei, Oana
A2 - Amaricai, Elena
A3 - Iacob, Emil Radu
A4 - Tirnea, Livius
A5 - Iacob, Daniela
A6 - Marginean, Otilia
A7 - Ancusa, Oana-Elena
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 5
SP - 414
EP - 426
UR - https://doi.org/10.37358/RC.20.5.8152
KW - proton-pump inhibitors; pharmacokinetic; side effects; dysbiosis
ER -

BibTex
@article{RevCh2020P414,
author = {Belei Oana and Amaricai Elena and Iacob Emil Radu and Tirnea Livius and Iacob Daniela and Marginean Otilia and Ancusa Oana-Elena},
title = {Proton-Pump Inhibitors in Adults and Pediatric Patients: Use and Abuse},
journal = {Revista de Chimie},
volume = {71},
number = {5},
pages = {414-426},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.5.8152},
url = {https://revistadechimie.ro/Articles.asp?ID=8152}
}

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