Chemical Treatment with Fluoroquinolones on the Tear Film and Ocular Surface after Cataract Surgery

Ghita, Aurelian Mihai; Ghita, Ana Cristina; Istrate, Sanziana; Balta, Florin; Ciuluvica, Radu

Aurelian Mihai Ghita, Ana Cristina Ghita, Sanziana Istrate, Florin Balta, Radu Ciuluvica

Chemical Treatment with Fluoroquinolones on the Tear Film and Ocular Surface after Cataract Surgery

Abstract:

Quinolone antibacterial activity is related to its chemical structure, a synthetic fluorinated analog of nalidixic acid. Cataract surgery is responsible for visual improvement having a major positive impact on the quality of patients’ lives. According to the international guidelines, the administration of levofloxacin after cataract surgery decreases the incidence of postoperatively endophthalmitis. In this context we aimed to study the impact of adding topical fluoroquinolones to the conventional treatment after cataract surgery on the ocular surface and tear film. 125 of eyes of 125 patients with cataract were included. The enrolled patients were divided into three groups, a control group of patients that received topical Tobramycin, Dexamethasone and Indomethacin, a second group where moxifloxacin was added and a third group with levofloxacin instead of moxifloxacin. For all the patients, tear film breakup time, Schirmer II test, slit lamp examination preoperatively and postoperatively at one week were performed together with individual Ocular Surface Disease Index at one week after cataract surgery. The test results revealed that 52% of our studied patients had an abnormal preoperatively tear film breakup time, and 76.8% after cataract surgery, with a statistically significant decrease of the measured values. The preoperatively measured quantity of tears presented a no statistically significant decrease one week after cataract surgery. Also, we found an increase in the percentage of patients with punctate epithelial erosions. It is important and useful to identify prior to surgery patients with ocular surface disease and the ones at risk to develop clinical manifestations in order to treat them accordingly because, cataract surgery exacerbates the preexistent ocular symptoms. The addition of topical fluoroquinolones after cataract surgery in patients with dry eye is safe, with minimal alterations of the ocular surface and tear production, without statistically significant differences as compared to the control group.

Keywords:
cataract surgery; topical fluoroquinolones; dry eye disease

Issue: 2020, Volume 71, Issue 5

Pages: 434-440

Publication date: 2020/5/29

https://doi.org/10.37358/RC.20.5.8154

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GHITA, A.M., GHITA, A.C., ISTRATE, S., BALTA, F., CIULUVICA, R., Chemical Treatment with Fluoroquinolones on the Tear Film and Ocular Surface after Cataract Surgery, Rev. Chim., 71(5), 2020, 434-440.

Vancouver
Ghita AM, Ghita AC, Istrate S, Balta F, Ciuluvica R. Chemical Treatment with Fluoroquinolones on the Tear Film and Ocular Surface after Cataract Surgery. Rev. Chim.[internet]. 2020 May;71(5):434-440. Available from: https://doi.org/10.37358/RC.20.5.8154

APA 6th edition
Ghita, A.M., Ghita, A.C., Istrate, S., Balta, F. & Ciuluvica, R. (2020). Chemical Treatment with Fluoroquinolones on the Tear Film and Ocular Surface after Cataract Surgery. Revista de Chimie, 71(5), 434-440. https://doi.org/10.37358/RC.20.5.8154

Harvard
Ghita, A.M., Ghita, A.C., Istrate, S., Balta, F., Ciuluvica, R. (2020). 'Chemical Treatment with Fluoroquinolones on the Tear Film and Ocular Surface after Cataract Surgery', Revista de Chimie, 71(5), pp. 434-440. https://doi.org/10.37358/RC.20.5.8154

IEEE
A.M. Ghita, A.C. Ghita, S. Istrate, F. Balta, R. Ciuluvica, "Chemical Treatment with Fluoroquinolones on the Tear Film and Ocular Surface after Cataract Surgery". Revista de Chimie, vol. 71, no. 5, pp. 434-440, 2020. [online]. https://doi.org/10.37358/RC.20.5.8154

Text
Aurelian Mihai Ghita, Ana Cristina Ghita, Sanziana Istrate, Florin Balta, Radu Ciuluvica,
Chemical Treatment with Fluoroquinolones on the Tear Film and Ocular Surface after Cataract Surgery,
Revista de Chimie,
Volume 71, Issue 5,
2020,
Pages 434-440,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.5.8154.
(https://revistadechimie.ro/Articles.asp?ID=8154)
Keywords: cataract surgery; topical fluoroquinolones; dry eye disease

RIS
TY - JOUR
T1 - Chemical Treatment with Fluoroquinolones on the Tear Film and Ocular Surface after Cataract Surgery
A1 - Ghita, Aurelian Mihai
A2 - Ghita, Ana Cristina
A3 - Istrate, Sanziana
A4 - Balta, Florin
A5 - Ciuluvica, Radu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 5
SP - 434
EP - 440
UR - https://doi.org/10.37358/RC.20.5.8154
KW - cataract surgery
KW - topical fluoroquinolones
KW - dry eye disease
ER -

BibTex
@article{RevCh2020P434,
author = {Ghita Aurelian Mihai and Ghita Ana Cristina and Istrate Sanziana and Balta Florin and Ciuluvica Radu},
title = {Chemical Treatment with Fluoroquinolones on the Tear Film and Ocular Surface after Cataract Surgery},
journal = {Revista de Chimie},
volume = {71},
number = {5},
pages = {434-440},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.5.8154},
url = {https://revistadechimie.ro/Articles.asp?ID=8154}
}

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