The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation

Doca, Sorin Cristian; Vlase, Gabriela; Vlase, Titus; Galuscan, Atena; Balean, Octavia; , Daniel Negru; Jumanca, Daniela

Sorin Cristian Doca, Gabriela Vlase, Titus Vlase, Atena Galuscan, Octavia Balean, Daniel Negru , Daniela Jumanca

The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation

Abstract:

A good bone augmentation and regeneration depends essentially on the use of a high biomimetic hydroxyapatite, respectively of an osteoclast apoptosis promoting compound. The last one, used in oral or injectable form, leads to different gastrointestinal side effects. We suggested and studied, at non-clinical level, a composite of sodium alendronate linked on a biogene hydroxyapatite. The composite was obtained by putting an aqueous solution of alendronate into a suspension of hydroxyapatite in acetone. By physico-chemical methods the binding of alendronate (ALE) on hydroxyapatite was proved, the content of ALE in the composite being 22%. The patients can benefit from this composite due to a total elimination of gastrointestinal side effects as a consequence of limiting the bioactivity only locally.

Keywords:
osteointegration; bisphosphonate; gastrointestinal diseases; alendronate - hydoxyapatite compound

Issue: 2020, Volume 71, Issue 6

Pages: 22-30

Publication date: 2020/7/1

https://doi.org/10.37358/RC.20.6.8166

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DOCA, S.C., VLASE, G., VLASE, T., GALUSCAN, A., BALEAN, O., , D.N., JUMANCA, D., The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation, Rev. Chim., 71(6), 2020, 22-30.

Vancouver
Doca SC, Vlase G, Vlase T, Galuscan A, Balean O, DN, Jumanca D. The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation. Rev. Chim.[internet]. 2020 Jun;71(6):22-30. Available from: https://doi.org/10.37358/RC.20.6.8166

APA 6th edition
Doca, S.C., Vlase, G., Vlase, T., Galuscan, A., Balean, O., , D.N. & Jumanca, D. (2020). The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation. Revista de Chimie, 71(6), 22-30. https://doi.org/10.37358/RC.20.6.8166

Harvard
Doca, S.C., Vlase, G., Vlase, T., Galuscan, A., Balean, O., , D.N., Jumanca, D. (2020). 'The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation', Revista de Chimie, 71(6), pp. 22-30. https://doi.org/10.37358/RC.20.6.8166

IEEE
S.C. Doca, G. Vlase, T. Vlase, A. Galuscan, O. Balean, D.N. , D. Jumanca, "The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation". Revista de Chimie, vol. 71, no. 6, pp. 22-30, 2020. [online]. https://doi.org/10.37358/RC.20.6.8166

Text
Sorin Cristian Doca, Gabriela Vlase, Titus Vlase, Atena Galuscan, Octavia Balean, Daniel Negru , Daniela Jumanca,
The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation,
Revista de Chimie,
Volume 71, Issue 6,
2020,
Pages 22-30,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.6.8166.
(https://revistadechimie.ro/Articles.asp?ID=8166)
Keywords: osteointegration; bisphosphonate; gastrointestinal diseases; alendronate - hydoxyapatite compound

RIS
TY - JOUR
T1 - The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation
A1 - Doca, Sorin Cristian
A2 - Vlase, Gabriela
A3 - Vlase, Titus
A4 - Galuscan, Atena
A5 - Balean, Octavia
A6 - , Daniel Negru
A7 - Jumanca, Daniela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 6
SP - 22
EP - 30
UR - https://doi.org/10.37358/RC.20.6.8166
KW - osteointegration
KW - bisphosphonate
KW - gastrointestinal diseases
KW - alendronate - hydoxyapatite compound
ER -

BibTex
@article{RevCh2020P22,
author = {Doca Sorin Cristian and Vlase Gabriela and Vlase Titus and Galuscan Atena and Balean Octavia and Daniel Negru and Jumanca Daniela},
title = {The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation},
journal = {Revista de Chimie},
volume = {71},
number = {6},
pages = {22-30},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.6.8166},
url = {https://revistadechimie.ro/Articles.asp?ID=8166}
}

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