The Treatment Effect of Highly Biocompatible Bismuth/ strontium/hydroxyapatite/chitosan for Osteosarcoma,  Bacterial and Bone Defects

Huang, Zhipeng; Liu, Chang; Lu, Yang; Su, Haoyuan; Wang, Qinglong; Zheng, Changming; Lu, Renpei; Song, Keguan

Zhipeng Huang, Chang Liu, Yang Lu, Haoyuan Su, Qinglong Wang, Changming Zheng, Renpei Lu, Keguan Song

The Treatment Effect of Highly Biocompatible Bismuth/ strontium/hydroxyapatite/chitosan for Osteosarcoma, Bacterial and Bone Defects

Abstract:

Bi particles are dispersed in hydroxyapatite/ strontium/chitosan material by mixed coprecipitation and freeze-drying method. In oder to assess their anti-tumor, osteogenic and antibacterial effects, SEM, EDS, FIRT, XRD, hemolysis and swell experiments were used to assess the physical properties of the material. Cytotoxicity assays, PCR techniques were used to assess the effects of material on bone cells, osteosarcoma cells. Flow cytometry was used to evaluate the effect of composites on osteosarcoma cells, and the inhibitory effect of material on Staphylococcus aureus was evaluated by antimicrobial susceptibility test. The results show that Bi/Sr/CS/HA composites have better anti-tumor, anti-infective and osteogenic functions than Sr/CS/HA composites with increasing niobium concentration. Furthermore, by analyzing the results, it is believed that the addition of Bi in composite material play important roles in enhancing the antibacterial, antitumor and osteogenesis of the composite.

Keywords:
Chitosan; strontium; hydroxyapatite; anti-tumor; osteogenesis; antibacterial

Issue: 2020, Volume 71, Issue 6

Pages: 111-123

Publication date: 2020/7/1

https://doi.org/10.37358/RC.20.6.8176

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
HUANG, Z., LIU, C., LU, Y., SU, H., WANG, Q., ZHENG, C., LU, R., SONG, K., The Treatment Effect of Highly Biocompatible Bismuth/ strontium/hydroxyapatite/chitosan for Osteosarcoma, Bacterial and Bone Defects, Rev. Chim., 71(6), 2020, 111-123.

Vancouver
Huang Z, Liu C, Lu Y, Su H, Wang Q, Zheng C, Lu R, Song K. The Treatment Effect of Highly Biocompatible Bismuth/ strontium/hydroxyapatite/chitosan for Osteosarcoma, Bacterial and Bone Defects. Rev. Chim.[internet]. 2020 Jun;71(6):111-123. Available from: https://doi.org/10.37358/RC.20.6.8176

APA 6th edition
Huang, Z., Liu, C., Lu, Y., Su, H., Wang, Q., Zheng, C., Lu, R. & Song, K. (2020). The Treatment Effect of Highly Biocompatible Bismuth/ strontium/hydroxyapatite/chitosan for Osteosarcoma, Bacterial and Bone Defects. Revista de Chimie, 71(6), 111-123. https://doi.org/10.37358/RC.20.6.8176

Harvard
Huang, Z., Liu, C., Lu, Y., Su, H., Wang, Q., Zheng, C., Lu, R., Song, K. (2020). 'The Treatment Effect of Highly Biocompatible Bismuth/ strontium/hydroxyapatite/chitosan for Osteosarcoma, Bacterial and Bone Defects', Revista de Chimie, 71(6), pp. 111-123. https://doi.org/10.37358/RC.20.6.8176

IEEE
Z. Huang, C. Liu, Y. Lu, H. Su, Q. Wang, C. Zheng, R. Lu, K. Song, "The Treatment Effect of Highly Biocompatible Bismuth/ strontium/hydroxyapatite/chitosan for Osteosarcoma, Bacterial and Bone Defects". Revista de Chimie, vol. 71, no. 6, pp. 111-123, 2020. [online]. https://doi.org/10.37358/RC.20.6.8176

Text
Zhipeng Huang, Chang Liu, Yang Lu, Haoyuan Su, Qinglong Wang, Changming Zheng, Renpei Lu, Keguan Song,
The Treatment Effect of Highly Biocompatible Bismuth/ strontium/hydroxyapatite/chitosan for Osteosarcoma, Bacterial and Bone Defects,
Revista de Chimie,
Volume 71, Issue 6,
2020,
Pages 111-123,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.6.8176.
(https://revistadechimie.ro/Articles.asp?ID=8176)
Keywords: Chitosan; strontium; hydroxyapatite; anti-tumor; osteogenesis; antibacterial

RIS
TY - JOUR
T1 - The Treatment Effect of Highly Biocompatible Bismuth/ strontium/hydroxyapatite/chitosan for Osteosarcoma, Bacterial and Bone Defects
A1 - Huang, Zhipeng
A2 - Liu, Chang
A3 - Lu, Yang
A4 - Su, Haoyuan
A5 - Wang, Qinglong
A6 - Zheng, Changming
A7 - Lu, Renpei
A8 - Song, Keguan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 6
SP - 111
EP - 123
UR - https://doi.org/10.37358/RC.20.6.8176
KW - Chitosan
KW - strontium
KW - hydroxyapatite
KW - anti-tumor
KW - osteogenesis
KW - antibacterial
ER -

BibTex
@article{RevCh2020P111,
author = {Huang Zhipeng and Liu Chang and Lu Yang and Su Haoyuan and Wang Qinglong and Zheng Changming and Lu Renpei and Song Keguan},
title = {The Treatment Effect of Highly Biocompatible Bismuth/ strontium/hydroxyapatite/chitosan for Osteosarcoma, Bacterial and Bone Defects},
journal = {Revista de Chimie},
volume = {71},
number = {6},
pages = {111-123},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.6.8176},
url = {https://revistadechimie.ro/Articles.asp?ID=8176}
}

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