Is the Histopathological Subtype Important for Tumor Response to Irradiation in non-metastatic Esophageal Cancers

Bacinschi, Xenia Elena; Anghel, Rodica Maricela; Stanuica, Monica Irina; Safta, Inga; Paunescu, Alina; Tantu, Monica Marilena; Ilie, Alis; Ilie, Silvia Mihaela

Xenia Elena Bacinschi, Rodica Maricela Anghel, Monica Irina Stanuica, Inga Safta, Alina Paunescu, Monica Marilena Tantu, Alis Ilie, Silvia Mihaela Ilie

Is the Histopathological Subtype Important for Tumor Response to Irradiation in non-metastatic Esophageal Cancers

Abstract:

Esophageal cancer is still a health problem in middle income countries. The up-front treatment in localized disease is crucial for a better survival. Data from literature are in favor of a better response to radiotherapy of squamous histology. We have run a retrospective study to compare the response of histological subtypes of esophageal cancer to radiotherapy according to irradiation. Of 44 cases (53.7%) of squamous cell localized esophageal carcinoma and 38 (46.3%) of adenocarcinoma, the response after radiotherapy containing multimodal neoadjuvant treatment was 29.5% (13pts) versus 39.5% (15pts) (p=0.475). No correlation was found between histology and tumor shrinkage. Survival was found similar between the two subgroups. Indeed, median relapse free survival was 11 months for both groups with 95% CI [8.86-13.13] or 95% CI [4.526-17.47], log rank 0.394 and median overall survival was 12 months, 95% CI [9.44-14.55] in squamous versus 15 months, 95% [8.30-21.69] in adenocarcinoma cases, log rank 0.195. In univariate regression, the median relapse free survival was significantly associated with irradiation dose and the concomitance of chemotherapy to radiotherapy, while in multivariate analysis only the last variable remained significant: HR 0.425, 95% CI [0.225-0.806], p=0.009. Our analysis showed a tendency to a better response in adenocarcinoma esophageal cancer after multimodal radiotherapy containing treatment.

Keywords:
radiotherapy; esophageal cancer; histopathological subtype ; squamous cell

Issue: 2020, Volume 71, Issue 6

Pages: 205-211

Publication date: 2020/7/1

https://doi.org/10.37358/RC.20.6.8184

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BACINSCHI, X.E., ANGHEL, R.M., STANUICA, M.I., SAFTA, I., PAUNESCU, A., TANTU, M.M., ILIE, A., ILIE, S.M., Is the Histopathological Subtype Important for Tumor Response to Irradiation in non-metastatic Esophageal Cancers, Rev. Chim., 71(6), 2020, 205-211.

Vancouver
Bacinschi XE, Anghel RM, Stanuica MI, Safta I, Paunescu A, Tantu MM, Ilie A, Ilie SM. Is the Histopathological Subtype Important for Tumor Response to Irradiation in non-metastatic Esophageal Cancers. Rev. Chim.[internet]. 2020 Jun;71(6):205-211. Available from: https://doi.org/10.37358/RC.20.6.8184

APA 6th edition
Bacinschi, X.E., Anghel, R.M., Stanuica, M.I., Safta, I., Paunescu, A., Tantu, M.M., Ilie, A. & Ilie, S.M. (2020). Is the Histopathological Subtype Important for Tumor Response to Irradiation in non-metastatic Esophageal Cancers. Revista de Chimie, 71(6), 205-211. https://doi.org/10.37358/RC.20.6.8184

Harvard
Bacinschi, X.E., Anghel, R.M., Stanuica, M.I., Safta, I., Paunescu, A., Tantu, M.M., Ilie, A., Ilie, S.M. (2020). 'Is the Histopathological Subtype Important for Tumor Response to Irradiation in non-metastatic Esophageal Cancers', Revista de Chimie, 71(6), pp. 205-211. https://doi.org/10.37358/RC.20.6.8184

IEEE
X.E. Bacinschi, R.M. Anghel, M.I. Stanuica, I. Safta, A. Paunescu, M.M. Tantu, A. Ilie, S.M. Ilie, "Is the Histopathological Subtype Important for Tumor Response to Irradiation in non-metastatic Esophageal Cancers". Revista de Chimie, vol. 71, no. 6, pp. 205-211, 2020. [online]. https://doi.org/10.37358/RC.20.6.8184

Text
Xenia Elena Bacinschi, Rodica Maricela Anghel, Monica Irina Stanuica, Inga Safta, Alina Paunescu, Monica Marilena Tantu, Alis Ilie, Silvia Mihaela Ilie,
Is the Histopathological Subtype Important for Tumor Response to Irradiation in non-metastatic Esophageal Cancers,
Revista de Chimie,
Volume 71, Issue 6,
2020,
Pages 205-211,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.6.8184.
(https://revistadechimie.ro/Articles.asp?ID=8184)
Keywords: radiotherapy; esophageal cancer; histopathological subtype ; squamous cell

RIS
TY - JOUR
T1 - Is the Histopathological Subtype Important for Tumor Response to Irradiation in non-metastatic Esophageal Cancers
A1 - Bacinschi, Xenia Elena
A2 - Anghel, Rodica Maricela
A3 - Stanuica, Monica Irina
A4 - Safta, Inga
A5 - Paunescu, Alina
A6 - Tantu, Monica Marilena
A7 - Ilie, Alis
A8 - Ilie, Silvia Mihaela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 6
SP - 205
EP - 211
UR - https://doi.org/10.37358/RC.20.6.8184
KW - radiotherapy
KW - esophageal cancer
KW - histopathological subtype
KW - squamous cell
ER -

BibTex
@article{RevCh2020P205,
author = {Bacinschi Xenia Elena and Anghel Rodica Maricela and Stanuica Monica Irina and Safta Inga and Paunescu Alina and Tantu Monica Marilena and Ilie Alis and Ilie Silvia Mihaela},
title = {Is the Histopathological Subtype Important for Tumor Response to Irradiation in non-metastatic Esophageal Cancers},
journal = {Revista de Chimie},
volume = {71},
number = {6},
pages = {205-211},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.6.8184},
url = {https://revistadechimie.ro/Articles.asp?ID=8184}
}

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