Renoprotective Effects of PLGA Nanoparticles Loaded  with Vitamin E in Wistar Rats, on  Hypercaloric  Diet

Dinu, Adriana; Virgolici, Bogdana; Miricescu, Daniela; Totan, Alexandra; Gagniuc, Elvira; Virgolici, Horia; Stefan, Daciana Costina; Greabu, Maria; Mohora, Maria

Adriana Dinu, Bogdana Virgolici, Daniela Miricescu, Alexandra Totan, Elvira Gagniuc, Horia Virgolici, Daciana Costina Stefan, Maria Greabu, Maria Mohora

Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet

Abstract:

Obesity is associated with renal lipomatosis, inflammation and oxidative stress. Vitamin E is a liposoluble antioxidant vitamin and PLGA (polylactic-CO-glycolic acid) nanoparticles (NPs) represent a delivery carrier of this vitamin to the abdominal viscera. The aim of this study is to evaluate the renal and systemic effects of PLGA- NPs loaded with vitamin E in high fat diet Wistar rats. Young heathy Wistar male rats (3months old, n=20) were fed for 4 weeks either with standard diet or with high caloric/fat diet. These two experimental groups were divided in two subgroups and for the following 21 days, one group received PLGA-NPs loaded with vitamin E (1 mg/kg) body and the other didn’t. Metabolic serum parameters, oxidative stress markers ( malondialdehyde, MDA and total thiols) from kidney homogenates were measured by spectrophotometric methods. Hematoxylin-eosin stain histopathologic examination of kidneys was performed. The obesogenic diet increased the serum levels for triglycerides (p[0.001) and renal function markers: urea (p[0.02), creatinine (p[0.02) and cystatin (p[0.01). The treatment reduced the kidney inflammation, prevented tubulonephrosis damage and improved the renal oxidative stress markers (p[0.05) in the high fat diet group. In conclusion, PLGA-NPs loaded with vitamin E had renoprotective effect in high fat diet Wistar rats.

Keywords:
vitamin E; fat diet; nanoparticles; oxidative stress

Issue: 2020, Volume 71, Issue 6

Pages: 230-237

Publication date: 2020/7/1

https://doi.org/10.37358/RC.20.6.8187

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DINU, A., VIRGOLICI, B., MIRICESCU, D., TOTAN, A., GAGNIUC, E., VIRGOLICI, H., STEFAN, D.C., GREABU, M., MOHORA, M., Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet, Rev. Chim., 71(6), 2020, 230-237.

Vancouver
Dinu A, Virgolici B, Miricescu D, Totan A, Gagniuc E, Virgolici H, Stefan DC, Greabu M, Mohora M. Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet. Rev. Chim.[internet]. 2020 Jun;71(6):230-237. Available from: https://doi.org/10.37358/RC.20.6.8187

APA 6th edition
Dinu, A., Virgolici, B., Miricescu, D., Totan, A., Gagniuc, E., Virgolici, H.,... Mohora, M. (2020). Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet. Revista de Chimie, 71(6), 230-237. https://doi.org/10.37358/RC.20.6.8187

Harvard
Dinu, A., Virgolici, B., Miricescu, D., Totan, A., Gagniuc, E., Virgolici, H., Stefan, D.C., Greabu, M., Mohora, M. (2020). 'Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet', Revista de Chimie, 71(6), pp. 230-237. https://doi.org/10.37358/RC.20.6.8187

IEEE
A. Dinu, B. Virgolici, D. Miricescu, A. Totan, E. Gagniuc, H. Virgolici, D.C. Stefan, M. Greabu, M. Mohora, "Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet". Revista de Chimie, vol. 71, no. 6, pp. 230-237, 2020. [online]. https://doi.org/10.37358/RC.20.6.8187

Text
Adriana Dinu, Bogdana Virgolici, Daniela Miricescu, Alexandra Totan, Elvira Gagniuc, Horia Virgolici, Daciana Costina Stefan, Maria Greabu, Maria Mohora,
Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet,
Revista de Chimie,
Volume 71, Issue 6,
2020,
Pages 230-237,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.6.8187.
(https://revistadechimie.ro/Articles.asp?ID=8187)
Keywords: vitamin E; fat diet; nanoparticles; oxidative stress

RIS
TY - JOUR
T1 - Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet
A1 - Dinu, Adriana
A2 - Virgolici, Bogdana
A3 - Miricescu, Daniela
A4 - Totan, Alexandra
A5 - Gagniuc, Elvira
A6 - Virgolici, Horia
A7 - Stefan, Daciana Costina
A8 - Greabu, Maria
A9 - Mohora, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 6
SP - 230
EP - 237
UR - https://doi.org/10.37358/RC.20.6.8187
KW - vitamin E
KW - fat diet
KW - nanoparticles
KW - oxidative stress
ER -

BibTex
@article{RevCh2020P230,
author = {Dinu Adriana and Virgolici Bogdana and Miricescu Daniela and Totan Alexandra and Gagniuc Elvira and Virgolici Horia and Stefan Daciana Costina and Greabu Maria and Mohora Maria},
title = {Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet},
journal = {Revista de Chimie},
volume = {71},
number = {6},
pages = {230-237},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.6.8187},
url = {https://revistadechimie.ro/Articles.asp?ID=8187}
}

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