Aspartame Consumption Increases Glutathione Peroxidase Level and Depression- Like Behavior in Rats

Enciu, Roxana-Rosmary; Trus, Constantin; Ungurianu, Sorin

Roxana-Rosmary Enciu, Constantin Trus, Sorin Ungurianu

Aspartame Consumption Increases Glutathione Peroxidase Level and Depression- Like Behavior in Rats

Abstract:

Aspartame is a worldwide used artificial sweetener and is consumed by millions of adults and children as part of their diet. The connection between aspartame ingestion and depression has been studied with contradictory results. We hypothesized that this correlation might be explained by high levels of oxidative stress. We wanted to examine the biochemical effects of consuming higher or lower doses of aspartame on the antioxidant enzyme- glutathione peroxidase (GPX) and on the depression-like behaviors of rats in the forced swim test model. 40 lab rats were divided into 4 groups; two groups were treated by gavage with either 75 mg/kg/day of aspartame or 125 mg/kg/day of aspartame. The control group received a gavage with vehicle (water). The naive group received no experimental intervention. Our statistical analysis revealed that the rats from the control group and the naive group presented a significantly lower level of GPX compared to the groups that received 75mg/kg/day or the group that received the maximum dosage of 125mg/kg/day aspartame. Furthermore, a shorter duration of the immobility was reported in the control and the naive groups when compared to the groups which received any of the two dosages of aspartame. Therefore, the results presented by our study suggest that aspartame consumption (in both high and low dosages) increases both the oxidative stress and the depression-like symptoms in the forced swim model. In addition, an aspartame dose-response was not found for either of our two variables: oxidative stress or depression. In conclusion, the daily consumption of aspartame for 4 weeks, in both high dosage and low dosage, had a negative impact on both oxidative stress level and the frequency of depression- like behaviors of the animals in the forced swim test. These results suggest that the correlation between aspartame ingestion and depression might be explained by oxidative stress levels.

Keywords:
aspartame; glutathione peroxidase; oxidative stress; depression; artificial sweetener

Issue: 2020, Volume 71, Issue 6

Pages: 247-253

Publication date: 2020/7/1

https://doi.org/10.37358/RC.20.6.8189

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ENCIU, R., TRUS, C., UNGURIANU, S., Aspartame Consumption Increases Glutathione Peroxidase Level and Depression- Like Behavior in Rats, Rev. Chim., 71(6), 2020, 247-253.

Vancouver
Enciu R, Trus C, Ungurianu S. Aspartame Consumption Increases Glutathione Peroxidase Level and Depression- Like Behavior in Rats. Rev. Chim.[internet]. 2020 Jun;71(6):247-253. Available from: https://doi.org/10.37358/RC.20.6.8189

APA 6th edition
Enciu, R., Trus, C. & Ungurianu, S. (2020). Aspartame Consumption Increases Glutathione Peroxidase Level and Depression- Like Behavior in Rats. Revista de Chimie, 71(6), 247-253. https://doi.org/10.37358/RC.20.6.8189

Harvard
Enciu, R., Trus, C., Ungurianu, S. (2020). 'Aspartame Consumption Increases Glutathione Peroxidase Level and Depression- Like Behavior in Rats', Revista de Chimie, 71(6), pp. 247-253. https://doi.org/10.37358/RC.20.6.8189

IEEE
R. Enciu, C. Trus, S. Ungurianu, "Aspartame Consumption Increases Glutathione Peroxidase Level and Depression- Like Behavior in Rats". Revista de Chimie, vol. 71, no. 6, pp. 247-253, 2020. [online]. https://doi.org/10.37358/RC.20.6.8189

Text
Roxana-Rosmary Enciu, Constantin Trus, Sorin Ungurianu,
Aspartame Consumption Increases Glutathione Peroxidase Level and Depression- Like Behavior in Rats,
Revista de Chimie,
Volume 71, Issue 6,
2020,
Pages 247-253,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.6.8189.
(https://revistadechimie.ro/Articles.asp?ID=8189)
Keywords: aspartame; glutathione peroxidase; oxidative stress; depression; artificial sweetener

RIS
TY - JOUR
T1 - Aspartame Consumption Increases Glutathione Peroxidase Level and Depression- Like Behavior in Rats
A1 - Enciu, Roxana-Rosmary
A2 - Trus, Constantin
A3 - Ungurianu, Sorin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 6
SP - 247
EP - 253
UR - https://doi.org/10.37358/RC.20.6.8189
KW - aspartame
KW - glutathione peroxidase
KW - oxidative stress
KW - depression
KW - artificial sweetener
ER -

BibTex
@article{RevCh2020P247,
author = {Enciu Roxana-Rosmary and Trus Constantin and Ungurianu Sorin},
title = {Aspartame Consumption Increases Glutathione Peroxidase Level and Depression- Like Behavior in Rats},
journal = {Revista de Chimie},
volume = {71},
number = {6},
pages = {247-253},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.6.8189},
url = {https://revistadechimie.ro/Articles.asp?ID=8189}
}

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