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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 6, 261-266

https://doi.org/10.37358/RC.20.6.8191

Natalia Guma, Andreea Nastase, Marilena Motoc, Speranta Avram

Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability

Abstract:

The N-acetyl group attached to monomeric glucosamine monomer units of chitin confers an extremely low solubility, which makes chitin difficult to process and therefore limiting its medical potential. In order to be used as a drug administration system in the body, it is important to know about the pharmacokinetic profiles of chitosan and its derivatives, more specifically about ADME-Tox profiles (absorption, distribution, metabolism, excretion, and toxicology). Through cheminformatics and bioinformatics tools, ADMET is identifying, a set of pharmacokinetic characteristics, such as absorption, distribution, metabolism, blood-brain barrier, nervous system barrier, and toxicological characteristics of chitosan and 5 of its derivatives. Our results have shown that one can try to integrate the drug delivery system into the body.
Keywords:
chitosan; chitosan derivatives; ADME-Tox; bioinformatics; cheminformatics

Issue: 2020, Volume 71, Issue 6
Pages: 261-266
Publication date: 2020/7/1
https://doi.org/10.37358/RC.20.6.8191
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
GUMA, N., NASTASE, A., MOTOC, M., AVRAM, S., Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability, Rev. Chim., 71(6), 2020, 261-266.

Vancouver
Guma N, Nastase A, Motoc M, Avram S. Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability. Rev. Chim.[internet]. 2020 Jun;71(6):261-266. Available from: https://doi.org/10.37358/RC.20.6.8191


APA 6th edition
Guma, N., Nastase, A., Motoc, M. & Avram, S. (2020). Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability. Revista de Chimie, 71(6), 261-266. https://doi.org/10.37358/RC.20.6.8191


Harvard
Guma, N., Nastase, A., Motoc, M., Avram, S. (2020). 'Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability', Revista de Chimie, 71(6), pp. 261-266. https://doi.org/10.37358/RC.20.6.8191


IEEE
N. Guma, A. Nastase, M. Motoc, S. Avram, "Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability". Revista de Chimie, vol. 71, no. 6, pp. 261-266, 2020. [online]. https://doi.org/10.37358/RC.20.6.8191


Text
Natalia Guma, Andreea Nastase, Marilena Motoc, Speranta Avram,
Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability,
Revista de Chimie,
Volume 71, Issue 6,
2020,
Pages 261-266,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.6.8191.
(https://revistadechimie.ro/Articles.asp?ID=8191)
Keywords: chitosan; chitosan derivatives; ADME-Tox; bioinformatics; cheminformatics


RIS
TY - JOUR
T1 - Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability
A1 - Guma, Natalia
A2 - Nastase, Andreea
A3 - Motoc, Marilena
A4 - Avram, Speranta
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 6
SP - 261
EP - 266
UR - https://doi.org/10.37358/RC.20.6.8191
KW - chitosan
KW - chitosan derivatives
KW - ADME-Tox
KW - bioinformatics
KW - cheminformatics
ER -


BibTex
@article{RevCh2020P261,
author = {Guma Natalia and Nastase Andreea and Motoc Marilena and Avram Speranta},
title = {Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability},
journal = {Revista de Chimie},
volume = {71},
number = {6},
pages = {261-266},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.6.8191},
url = {https://revistadechimie.ro/Articles.asp?ID=8191}
}
 
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