Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study

Kocic, Branislava D.; Dordevic, Dobrila M. Stankovic; Dimitrijevic, Marija V.; Markovic, Marija S.; Miladinovic, Dragoljub L.

Branislava D. Kocic, Dobrila M. Stankovic Dordevic, Marija V. Dimitrijevic, Marija S. Markovic, Dragoljub L. Miladinovic

Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study

Abstract:

The susceptibility of Helicobacter pylori to three essential oils (EOs), 12 naturally occurring monoterpene hydrocarbons, oxygenated and phenolic monoterpenes and three reference antibiotics were studied. Classification and comparison of essential oils and monoterpenes on the basis of their chemical composition and antibacterial activity were made by the utilization of principal component analyses (PCA) and agglomerative hierarchical clustering (AHC). The most abundant compound in the Thymus glabrescens Willd. and Thymus pulegioides L. EOs is geraniol (33.8% and 52.5%), while the main constituent in Satureja kitaibelii Wierzb. ex Heuff. EO is limonene (16,1%). The compound that was the most active against H. pylori was carvacrol. EOs of T. glabrescens and S. kitaibelii exhibit higher antibacterial ability in comparison with all monoterpenes, except carvacrol, probably based on the concept of synergistic activity of essential oil components. PCA separated essential oils based on chemical composition and explain 96.5% of the total variance in the first two principal components. Essential oils, phenolic monoterpenes and two antibiotics were classified in the same sub-cluster within AHC analyses. EOs of T. glabrescens and S. kitaibelii can be used to treat infections caused by H. pylori, as a potentially effective, cheap and safe natural products. Further research of antibacterial activity of selected monoterpenes, essential oils and standard antibiotic combinations, as well as clinical study are required.

Keywords:
Chemometric; Helicobacter pylori; esential oils; monoterpenes; microdilution method

Issue: 2020, Volume 71, Issue 6

Pages: 267-273

Publication date: 2020/7/1

https://doi.org/10.37358/RC.20.6.8192

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
KOCIC, B.D., DORDEVIC, D.M.S., DIMITRIJEVIC, M.V., MARKOVIC, M.S., MILADINOVIC, D.L., Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study, Rev. Chim., 71(6), 2020, 267-273.

Vancouver
Kocic BD, Dordevic DMS, Dimitrijevic MV, Markovic MS, Miladinovic DL. Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study. Rev. Chim.[internet]. 2020 Jun;71(6):267-273. Available from: https://doi.org/10.37358/RC.20.6.8192

APA 6th edition
Kocic, B.D., Dordevic, D.M.S., Dimitrijevic, M.V., Markovic, M.S. & Miladinovic, D.L. (2020). Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study. Revista de Chimie, 71(6), 267-273. https://doi.org/10.37358/RC.20.6.8192

Harvard
Kocic, B.D., Dordevic, D.M.S., Dimitrijevic, M.V., Markovic, M.S., Miladinovic, D.L. (2020). 'Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study', Revista de Chimie, 71(6), pp. 267-273. https://doi.org/10.37358/RC.20.6.8192

IEEE
B.D. Kocic, D.M.S. Dordevic, M.V. Dimitrijevic, M.S. Markovic, D.L. Miladinovic, "Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study". Revista de Chimie, vol. 71, no. 6, pp. 267-273, 2020. [online]. https://doi.org/10.37358/RC.20.6.8192

Text
Branislava D. Kocic, Dobrila M. Stankovic Dordevic, Marija V. Dimitrijevic, Marija S. Markovic, Dragoljub L. Miladinovic,
Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study,
Revista de Chimie,
Volume 71, Issue 6,
2020,
Pages 267-273,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.6.8192.
(https://revistadechimie.ro/Articles.asp?ID=8192)
Keywords: Chemometric; Helicobacter pylori; esential oils; monoterpenes; microdilution method

RIS
TY - JOUR
T1 - Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study
A1 - Kocic, Branislava D.
A2 - Dordevic, Dobrila M. Stankovic
A3 - Dimitrijevic, Marija V.
A4 - Markovic, Marija S.
A5 - Miladinovic, Dragoljub L.
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 6
SP - 267
EP - 273
UR - https://doi.org/10.37358/RC.20.6.8192
KW - Chemometric
KW - Helicobacter pylori
KW - esential oils
KW - monoterpenes
KW - microdilution method
ER -

BibTex
@article{RevCh2020P267,
author = {Kocic Branislava D. and Dordevic Dobrila M. Stankovic and Dimitrijevic Marija V. and Markovic Marija S. and Miladinovic Dragoljub L.},
title = {Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study},
journal = {Revista de Chimie},
volume = {71},
number = {6},
pages = {267-273},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.6.8192},
url = {https://revistadechimie.ro/Articles.asp?ID=8192}
}

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