Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery

Radulescu, Dumitru; Baleanu, Vlad Dumitru; Nicolaescu, Andrei; Lazar, Marius; Bica, Marius; Georgescu, Eugen Florin; Surlin, Marin Valeriu; Georgescu, Ion; Popescu, Adelina Tamara

Dumitru Radulescu, Vlad Dumitru Baleanu, Andrei Nicolaescu, Marius Lazar, Marius Bica, Eugen Florin Georgescu, Marin Valeriu Surlin, Ion Georgescu, Adelina Tamara Popescu

Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery

Abstract:

Anastomotic fistula is a dreadful complication of colon and rectal surgery that can put life into danger, being common after colorectal surgery. The preoperative lymphocyte neutrophil ratio (NLR) is known as a prognostic marker for colorectal cancer patients. The existence of a predictive marker of anastomotic fistula in colorectal cancer patients is not fully undestood, so we proposed to investigate the utility of preoperative NLR as a predictor of anastomotic fistula formation. This study the Neutrophils and lymphocytes were detected from periferic blood using flow citometry. We retrospectively evaluated 161 patients with colorectal cancer, who were treated curatively, in which at least one anastomosis was performed, comparing NLR values between patients who had fistula and those with normal healing, then comparing the group with low NLR, with the group with increased NLR, after finding the optimal value of NLR using the ROC curve.The optimal value of the NLR after establishing the cutoff value was 3.07. Between the low NLR group (n=134) and the high NLR group (n=27), were observed statistically significant differences in fistula (p [0.001) and death (p=0.001). The odds ratio for failure in the group with increased NLR was 10.37, which means that patients with NLR]3.54 have a chance of developing anastomotic fistula greater than 10.37 comparable to patients with lower NLR. We suggest the preoperative use of NLR can be used as a predictive marker of anastomotic fistula than can increase the quality of preoperative preparation and therefore the establishment of the optimal surgical technique that can lead to anastomotic fistula risk decrease.

Keywords:

anastomotic; fistula; gastric cancer; predictive; preoperative; NLR

Issue: 2020, Volume 71, Issue 6

Pages: 295-306

Publication date: 2020/7/1

https://doi.org/10.37358/RC.20.6.8195

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
RADULESCU, D., BALEANU, V.D., NICOLAESCU, A., LAZAR, M., BICA, M., GEORGESCU, E.F., SURLIN, M.V., GEORGESCU, I., POPESCU, A.T., Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery, Rev. Chim., 71(6), 2020, 295-306.

Vancouver
Radulescu D, Baleanu VD, Nicolaescu A, Lazar M, Bica M, Georgescu EF, Surlin MV, Georgescu I, Popescu AT. Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery. Rev. Chim.[internet]. 2020 Jun;71(6):295-306. Available from: https://doi.org/10.37358/RC.20.6.8195

APA 6th edition
Radulescu, D., Baleanu, V.D., Nicolaescu, A., Lazar, M., Bica, M., Georgescu, E.F.,... Popescu, A.T. (2020). Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery. Revista de Chimie, 71(6), 295-306. https://doi.org/10.37358/RC.20.6.8195

Harvard
Radulescu, D., Baleanu, V.D., Nicolaescu, A., Lazar, M., Bica, M., Georgescu, E.F., Surlin, M.V., Georgescu, I., Popescu, A.T. (2020). 'Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery', Revista de Chimie, 71(6), pp. 295-306. https://doi.org/10.37358/RC.20.6.8195

IEEE
D. Radulescu, V.D. Baleanu, A. Nicolaescu, M. Lazar, M. Bica, E.F. Georgescu, M.V. Surlin, I. Georgescu, A.T. Popescu, "Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery". Revista de Chimie, vol. 71, no. 6, pp. 295-306, 2020. [online]. https://doi.org/10.37358/RC.20.6.8195

Text
Dumitru Radulescu, Vlad Dumitru Baleanu, Andrei Nicolaescu, Marius Lazar, Marius Bica, Eugen Florin Georgescu, Marin Valeriu Surlin, Ion Georgescu, Adelina Tamara Popescu,
Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery,
Revista de Chimie,
Volume 71, Issue 6,
2020,
Pages 295-306,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.6.8195.
(https://revistadechimie.ro/Articles.asp?ID=8195)
Keywords:
anastomotic; fistula; gastric cancer; predictive; preoperative; NLR

RIS
TY - JOUR
T1 - Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery
A1 - Radulescu, Dumitru
A2 - Baleanu, Vlad Dumitru
A3 - Nicolaescu, Andrei
A4 - Lazar, Marius
A5 - Bica, Marius
A6 - Georgescu, Eugen Florin
A7 - Surlin, Marin Valeriu
A8 - Georgescu, Ion
A9 - Popescu, Adelina Tamara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 6
SP - 295
EP - 306
UR - https://doi.org/10.37358/RC.20.6.8195
KW -
anastomotic
KW - fistula
KW - gastric cancer
KW - predictive
KW - preoperative
KW - NLR
ER -

BibTex
@article{RevCh2020P295,
author = {Radulescu Dumitru and Baleanu Vlad Dumitru and Nicolaescu Andrei and Lazar Marius and Bica Marius and Georgescu Eugen Florin and Surlin Marin Valeriu and Georgescu Ion and Popescu Adelina Tamara},
title = {Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery},
journal = {Revista de Chimie},
volume = {71},
number = {6},
pages = {295-306},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.6.8195},
url = {https://revistadechimie.ro/Articles.asp?ID=8195}
}

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