Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery

Pattanaik, Sunil; Nandi, Souvik; Sahoo, Rudra Narayana; Nanda, Ashirbad; Swain, Rakesh; Das, Shubhashree; Mallick, Subrata

Sunil Pattanaik, Souvik Nandi, Rudra Narayana Sahoo, Ashirbad Nanda, Rakesh Swain, Shubhashree Das, Subrata Mallick

Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery

Abstract:

Budesonide, a glucocorticosteroid is generally used to treat chronic inflammation and asthma. Hepatic first-pass metabolism and poor solubility are the major causes of its limited oral bioavailability. Present work was undertaken for the preparation of hydrogel film formulation with cyclodextrin complexation of budesonide containing quaternary surfactant for possible enhancement of mucosal permeation. FTIR study confirmed drug-polymer hydrogen bonding. Almost complete amorphization of the drug was pronounced by SEM, DSC and XRD studies. The film containing benzalkonium and hydroxypropyl beta-cyclodextrin exhibited in vitro dissolution and mucosal permeation to the highest extent of 87.2 and 95.8 % respectively in contrast to the others. Film formed hydrogel in aqueous mucin and enhanced the mucosal tissue residence time due to the mucoadhesive nature of the polymer. Acute inflammation in the rabbit eye was controlled within 3 h by applying the film in the cul-de-sac. The presence of cyclodextrin and quaternary surfactant brought about significantly improved drug release and mucosal permeation compared to their absence in the HPMC film. Hydrogel formed in aqueous mucin enhanced the mucosal residence time and controlled acute inflammation in the rabbit eye within 3 h after topical application.

Keywords:
Budesonide; cyclodextrin inclusion; mucosal delivery; ocular anti-inflammation

Issue: 2020, Volume 71, Issue 6

Pages: 332-345

Publication date: 2020/7/1

https://doi.org/10.37358/RC.20.6.8200

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PATTANAIK, S., NANDI, S., SAHOO, R.N., NANDA, A., SWAIN, R., DAS, S., MALLICK, S., Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery, Rev. Chim., 71(6), 2020, 332-345.

Vancouver
Pattanaik S, Nandi S, Sahoo RN, Nanda A, Swain R, Das S, Mallick S. Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery. Rev. Chim.[internet]. 2020 Jun;71(6):332-345. Available from: https://doi.org/10.37358/RC.20.6.8200

APA 6th edition
Pattanaik, S., Nandi, S., Sahoo, R.N., Nanda, A., Swain, R., Das, S. & Mallick, S. (2020). Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery. Revista de Chimie, 71(6), 332-345. https://doi.org/10.37358/RC.20.6.8200

Harvard
Pattanaik, S., Nandi, S., Sahoo, R.N., Nanda, A., Swain, R., Das, S., Mallick, S. (2020). 'Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery', Revista de Chimie, 71(6), pp. 332-345. https://doi.org/10.37358/RC.20.6.8200

IEEE
S. Pattanaik, S. Nandi, R.N. Sahoo, A. Nanda, R. Swain, S. Das, S. Mallick, "Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery". Revista de Chimie, vol. 71, no. 6, pp. 332-345, 2020. [online]. https://doi.org/10.37358/RC.20.6.8200

Text
Sunil Pattanaik, Souvik Nandi, Rudra Narayana Sahoo, Ashirbad Nanda, Rakesh Swain, Shubhashree Das, Subrata Mallick,
Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery,
Revista de Chimie,
Volume 71, Issue 6,
2020,
Pages 332-345,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.6.8200.
(https://revistadechimie.ro/Articles.asp?ID=8200)
Keywords: Budesonide; cyclodextrin inclusion; mucosal delivery; ocular anti-inflammation

RIS
TY - JOUR
T1 - Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery
A1 - Pattanaik, Sunil
A2 - Nandi, Souvik
A3 - Sahoo, Rudra Narayana
A4 - Nanda, Ashirbad
A5 - Swain, Rakesh
A6 - Das, Shubhashree
A7 - Mallick, Subrata
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 6
SP - 332
EP - 345
UR - https://doi.org/10.37358/RC.20.6.8200
KW - Budesonide
KW - cyclodextrin inclusion
KW - mucosal delivery
KW - ocular anti-inflammation
ER -

BibTex
@article{RevCh2020P332,
author = {Pattanaik Sunil and Nandi Souvik and Sahoo Rudra Narayana and Nanda Ashirbad and Swain Rakesh and Das Shubhashree and Mallick Subrata},
title = {Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery},
journal = {Revista de Chimie},
volume = {71},
number = {6},
pages = {332-345},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.6.8200},
url = {https://revistadechimie.ro/Articles.asp?ID=8200}
}

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