Synthesis and Antimicrobial Activities of Novel Rutin Derivatives Carrying Quinoline Moiety

Lupascu, Dan; Profire, Lenuta; Apotrosoaei, Maria; Tuchilus, Cristina; Vasincu, Ioana Mirela; Iacob, Andreea Teodora; Tauser, Roxana Georgiana; Lupascu, Florentina-Geanina

Dan Lupascu, Lenuta Profire, Maria Apotrosoaei, Cristina Tuchilus, Ioana Mirela Vasincu, Andreea Teodora Iacob, Roxana Georgiana Tauser, Florentina-Geanina Lupascu

Synthesis and Antimicrobial Activities of Novel Rutin Derivatives Carrying Quinoline Moiety

Abstract:

Antimicrobial resistance constitutes a topical subject and it is one of the major threats to public health. According to statistics, the incidence of multidrug-resistant microorganisms, such as bacteria, fungi and protozoa has increased in the last decades and it continues to spread. Therefore, the development of novel antimicrobial agents to combat drug-resistant infections is very important, among other research directions in this field. Quinoline ring is a very interesting structure for researchers because of its diverse biological properties (antimicrobial, anticancer, anticonvulsant, antiinflamatory and cardiovascular). On the other hand several studies showed good antibacterial activity (including anti-Pseudomonas effects) and antifungal properties of rutin or vegetal species with a high flavonoids (especially rutin) concentration. Based on the above considerations, eight novel rutin derivatives carrying 4- and 8-aminoquinoline moiety were designed, synthesized and characterized by FTIR, 1H NMR and elemental analysis. All compounds were evaluated for their in vitro antimicrobial activities against representative Gram-positive, Gram-negative and fungal pathogens. The results indicated that all rutin derivatives exhibited good antibacterial activities, similar to ciprofloxacin.

Keywords:
flavonoids; rutin; quinoline; antimicrobial

Issue: 2020, Volume 71, Issue 6

Pages: 401-407

Publication date: 2020/7/1

https://doi.org/10.37358/RC.20.6.8206

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
LUPASCU, D., PROFIRE, L., APOTROSOAEI, M., TUCHILUS, C., VASINCU, I.M., IACOB, A.T., TAUSER, R.G., LUPASCU, F., Synthesis and Antimicrobial Activities of Novel Rutin Derivatives Carrying Quinoline Moiety, Rev. Chim., 71(6), 2020, 401-407.

Vancouver
Lupascu D, Profire L, Apotrosoaei M, Tuchilus C, Vasincu IM, Iacob AT, Tauser RG, Lupascu F. Synthesis and Antimicrobial Activities of Novel Rutin Derivatives Carrying Quinoline Moiety. Rev. Chim.[internet]. 2020 Jun;71(6):401-407. Available from: https://doi.org/10.37358/RC.20.6.8206

APA 6th edition
Lupascu, D., Profire, L., Apotrosoaei, M., Tuchilus, C., Vasincu, I.M., Iacob, A.T., Tauser, R.G. & Lupascu, F. (2020). Synthesis and Antimicrobial Activities of Novel Rutin Derivatives Carrying Quinoline Moiety. Revista de Chimie, 71(6), 401-407. https://doi.org/10.37358/RC.20.6.8206

Harvard
Lupascu, D., Profire, L., Apotrosoaei, M., Tuchilus, C., Vasincu, I.M., Iacob, A.T., Tauser, R.G., Lupascu, F. (2020). 'Synthesis and Antimicrobial Activities of Novel Rutin Derivatives Carrying Quinoline Moiety', Revista de Chimie, 71(6), pp. 401-407. https://doi.org/10.37358/RC.20.6.8206

IEEE
D. Lupascu, L. Profire, M. Apotrosoaei, C. Tuchilus, I.M. Vasincu, A.T. Iacob, R.G. Tauser, F. Lupascu, "Synthesis and Antimicrobial Activities of Novel Rutin Derivatives Carrying Quinoline Moiety". Revista de Chimie, vol. 71, no. 6, pp. 401-407, 2020. [online]. https://doi.org/10.37358/RC.20.6.8206

Text
Dan Lupascu, Lenuta Profire, Maria Apotrosoaei, Cristina Tuchilus, Ioana Mirela Vasincu, Andreea Teodora Iacob, Roxana Georgiana Tauser, Florentina-Geanina Lupascu,
Synthesis and Antimicrobial Activities of Novel Rutin Derivatives Carrying Quinoline Moiety,
Revista de Chimie,
Volume 71, Issue 6,
2020,
Pages 401-407,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.6.8206.
(https://revistadechimie.ro/Articles.asp?ID=8206)
Keywords: flavonoids; rutin; quinoline; antimicrobial

RIS
TY - JOUR
T1 - Synthesis and Antimicrobial Activities of Novel Rutin Derivatives Carrying Quinoline Moiety
A1 - Lupascu, Dan
A2 - Profire, Lenuta
A3 - Apotrosoaei, Maria
A4 - Tuchilus, Cristina
A5 - Vasincu, Ioana Mirela
A6 - Iacob, Andreea Teodora
A7 - Tauser, Roxana Georgiana
A8 - Lupascu, Florentina-Geanina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 6
SP - 401
EP - 407
UR - https://doi.org/10.37358/RC.20.6.8206
KW - flavonoids
KW - rutin
KW - quinoline
KW - antimicrobial

ER -

BibTex
@article{RevCh2020P401,
author = {Lupascu Dan and Profire Lenuta and Apotrosoaei Maria and Tuchilus Cristina and Vasincu Ioana Mirela and Iacob Andreea Teodora and Tauser Roxana Georgiana and Lupascu Florentina-Geanina},
title = {Synthesis and Antimicrobial Activities of Novel Rutin Derivatives Carrying Quinoline Moiety},
journal = {Revista de Chimie},
volume = {71},
number = {6},
pages = {401-407},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.6.8206},
url = {https://revistadechimie.ro/Articles.asp?ID=8206}
}

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