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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 7, 337-346

https://doi.org/10.37358/RC.20.7.8252

Vasile-Ion Iancu, Niculescu Marcela, Diana Puiu, Toma Galaon, Jana Petre, Luoana Florentina Pascu

Determination of Hypoglycemic Agents in Surface Water Samples Using SPE-LC-MS/MS Method

Abstract:

Antidiabetic compounds are a class of emerging contaminants in environment, for which there are no regulations in the world environmental legislation. These compounds are among the most widely used drugs in the world due to the large number of patients with diabetic conditions. The presence of these pollutants in the environment is insufficiently studied, so efficient analytical methods are needed to allow their detection at trace levels (ng/L). For the simultaneously quantification of the five antidiabetics (glyburide, metformin, glipizide, gliclazide, glimepiride) and one bio-degradation product (guanyl urea) in surface water samples a SPE-LC-MS/MS (solid phase extraction -liquid chromatography coupled with mass spectrometry detection) method was validated using real river water samples. The compounds were separated on C18 LC column in 9 minutes at 300C using a gradient of mobile phase of 0.1% formic acid and acetonitrile. Good performance parameters were obtained using the method: low limits of quantification (LOQs 0.1-2.4 ng/L), precision (repeatability 3.5-7.2% and reproducibility 6.5-12.7%) and determination coefficients (higher than 0.99). The most contaminated river was represented by Ialomita, which had a total concentration of antidiabetics of 112.1 ng/L in the downstream point, followed by the Siret and Dambovita rivers, which had a total concentration of antidiabetics of 66.3 ng/L and 57.3 ng/L, respectively, also in the downstream points.
Keywords:
hypoglicemic agents (anditiabetics); surface water (river); SPE-LC-MS/MS

Issue: 2020, Volume 71, Issue 7
Pages: 337-346
Publication date: 2020/8/4
https://doi.org/10.37358/RC.20.7.8252
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
IANCU, V., MARCELA, N., PUIU, D., GALAON, T., PETRE, J., PASCU, L.F., Determination of Hypoglycemic Agents in Surface Water Samples Using SPE-LC-MS/MS Method, Rev. Chim., 71(7), 2020, 337-346.

Vancouver
Iancu V, Marcela N, Puiu D, Galaon T, Petre J, Pascu LF. Determination of Hypoglycemic Agents in Surface Water Samples Using SPE-LC-MS/MS Method. Rev. Chim.[internet]. 2020 Jul;71(7):337-346. Available from: https://doi.org/10.37358/RC.20.7.8252


APA 6th edition
Iancu, V., Marcela, N., Puiu, D., Galaon, T., Petre, J. & Pascu, L.F. (2020). Determination of Hypoglycemic Agents in Surface Water Samples Using SPE-LC-MS/MS Method. Revista de Chimie, 71(7), 337-346. https://doi.org/10.37358/RC.20.7.8252


Harvard
Iancu, V., Marcela, N., Puiu, D., Galaon, T., Petre, J., Pascu, L.F. (2020). 'Determination of Hypoglycemic Agents in Surface Water Samples Using SPE-LC-MS/MS Method', Revista de Chimie, 71(7), pp. 337-346. https://doi.org/10.37358/RC.20.7.8252


IEEE
V. Iancu, N. Marcela, D. Puiu, T. Galaon, J. Petre, L.F. Pascu, "Determination of Hypoglycemic Agents in Surface Water Samples Using SPE-LC-MS/MS Method". Revista de Chimie, vol. 71, no. 7, pp. 337-346, 2020. [online]. https://doi.org/10.37358/RC.20.7.8252


Text
Vasile-Ion Iancu, Niculescu Marcela, Diana Puiu, Toma Galaon, Jana Petre, Luoana Florentina Pascu,
Determination of Hypoglycemic Agents in Surface Water Samples Using SPE-LC-MS/MS Method,
Revista de Chimie,
Volume 71, Issue 7,
2020,
Pages 337-346,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.7.8252.
(https://revistadechimie.ro/Articles.asp?ID=8252)
Keywords: hypoglicemic agents (anditiabetics); surface water (river); SPE-LC-MS/MS


RIS
TY - JOUR
T1 - Determination of Hypoglycemic Agents in Surface Water Samples Using SPE-LC-MS/MS Method
A1 - Iancu, Vasile-Ion
A2 - Marcela, Niculescu
A3 - Puiu, Diana
A4 - Galaon, Toma
A5 - Petre, Jana
A6 - Pascu, Luoana Florentina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 7
SP - 337
EP - 346
UR - https://doi.org/10.37358/RC.20.7.8252
KW - hypoglicemic agents (anditiabetics)
KW - surface water (river)
KW - SPE-LC-MS/MS
ER -


BibTex
@article{RevCh2020P337,
author = {Iancu Vasile-Ion and Marcela Niculescu and Puiu Diana and Galaon Toma and Petre Jana and Pascu Luoana Florentina},
title = {Determination of Hypoglycemic Agents in Surface Water Samples Using SPE-LC-MS/MS Method},
journal = {Revista de Chimie},
volume = {71},
number = {7},
pages = {337-346},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.7.8252},
url = {https://revistadechimie.ro/Articles.asp?ID=8252}
}
 
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