The Role of Cytokine in the Diagnosis and Monitoring of Patients with Systemic Infections

Iancu, Alina Viorica; Gurau, Gabriela; Dumitru, Caterina; Baroiu, Liliana; Chifiriuc, Mariana Carmen; Lazar, Veronica; Arbune, Manuela; Coman, Gigi; Draganescu, Miruna

Alina Viorica Iancu, Gabriela Gurau, Caterina Dumitru, Liliana Baroiu, Mariana Carmen Chifiriuc, Veronica Lazar, Manuela Arbune, Gigi Coman, Miruna Draganescu

The Role of Cytokine in the Diagnosis and Monitoring of Patients with Systemic Infections

Abstract:

Sepsis is an immunologic disorder with a high rate of mortality which is caused by the exacerbation of the inflammatory response. The purpose of this study was to characterise the etiologic spectrum and the profile of the most significant pro-inflammatory and anti-inflammatory citokines in patients with sistemic infections, by analysing the relationship between the type of etiologic agents and the intensity of the inflammatory response. The study was carried out on a number of 33 patients with systemic infections who were hospitalized in the “Saint Parascheva ”Infectious Diseases Clinic Hospital in Galati, Romania. The intensity of the inflammatory response was higher in the sepsis with Gram-negative Bacilli (BGN) as compared to the systemic infections produced by Gram-positive Cocci (CGP). In the case of the patients with bacterial etiology (CGP and BGN) there was evidence of an increase levels of analysed cytokines (TNF-a, IL-1, IL-4, IL-6, IL-10), while the fungal etiology was correlated with high serum concentrations of TNF-a. The levels of IL-4 and IL-6 were similar in all patients with systemic infections, regardless of their etiology. The Klebsiella pneumoniae sepsis has led to the occurrennce of high serum levels both in the case of pro-inflammatory and anti-inflammatory citokines. The obtained results outline the necessity of monitoring pro-inflammatory and anti- inflammatory cytokines in sepsis, which might provide clues about the intensity of the generalized inflammatory reaction, representing not only an important diagnosis criteria but also a useful guide in the therapeutic methods chosen and the monitoring of these severe infections.

Keywords:
pro- and anti-inflammatory cytokines; systemic infections; sepsis

Issue: 2020, Volume 71, Issue 7

Pages: 455-463

Publication date: 2020/8/4

https://doi.org/10.37358/RC.20.7.8263

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IANCU, A.V., GURAU, G., DUMITRU, C., BAROIU, L., CHIFIRIUC, M.C., LAZAR, V., ARBUNE, M., COMAN, G., DRAGANESCU, M., The Role of Cytokine in the Diagnosis and Monitoring of Patients with Systemic Infections, Rev. Chim., 71(7), 2020, 455-463.

Vancouver
Iancu AV, Gurau G, Dumitru C, Baroiu L, Chifiriuc MC, Lazar V, Arbune M, Coman G, Draganescu M. The Role of Cytokine in the Diagnosis and Monitoring of Patients with Systemic Infections. Rev. Chim.[internet]. 2020 Jul;71(7):455-463. Available from: https://doi.org/10.37358/RC.20.7.8263

APA 6th edition
Iancu, A.V., Gurau, G., Dumitru, C., Baroiu, L., Chifiriuc, M.C., Lazar, V.,... Draganescu, M. (2020). The Role of Cytokine in the Diagnosis and Monitoring of Patients with Systemic Infections. Revista de Chimie, 71(7), 455-463. https://doi.org/10.37358/RC.20.7.8263

Harvard
Iancu, A.V., Gurau, G., Dumitru, C., Baroiu, L., Chifiriuc, M.C., Lazar, V., Arbune, M., Coman, G., Draganescu, M. (2020). 'The Role of Cytokine in the Diagnosis and Monitoring of Patients with Systemic Infections', Revista de Chimie, 71(7), pp. 455-463. https://doi.org/10.37358/RC.20.7.8263

IEEE
A.V. Iancu, G. Gurau, C. Dumitru, L. Baroiu, M.C. Chifiriuc, V. Lazar, M. Arbune, G. Coman, M. Draganescu, "The Role of Cytokine in the Diagnosis and Monitoring of Patients with Systemic Infections". Revista de Chimie, vol. 71, no. 7, pp. 455-463, 2020. [online]. https://doi.org/10.37358/RC.20.7.8263

Text
Alina Viorica Iancu, Gabriela Gurau, Caterina Dumitru, Liliana Baroiu, Mariana Carmen Chifiriuc, Veronica Lazar, Manuela Arbune, Gigi Coman, Miruna Draganescu,
The Role of Cytokine in the Diagnosis and Monitoring of Patients with Systemic Infections,
Revista de Chimie,
Volume 71, Issue 7,
2020,
Pages 455-463,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.7.8263.
(https://revistadechimie.ro/Articles.asp?ID=8263)
Keywords: pro- and anti-inflammatory cytokines; systemic infections; sepsis

RIS
TY - JOUR
T1 - The Role of Cytokine in the Diagnosis and Monitoring of Patients with Systemic Infections
A1 - Iancu, Alina Viorica
A2 - Gurau, Gabriela
A3 - Dumitru, Caterina
A4 - Baroiu, Liliana
A5 - Chifiriuc, Mariana Carmen
A6 - Lazar, Veronica
A7 - Arbune, Manuela
A8 - Coman, Gigi
A9 - Draganescu, Miruna
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 7
SP - 455
EP - 463
UR - https://doi.org/10.37358/RC.20.7.8263
KW - pro- and anti-inflammatory cytokines
KW - systemic infections
KW - sepsis
ER -

BibTex
@article{RevCh2020P455,
author = {Iancu Alina Viorica and Gurau Gabriela and Dumitru Caterina and Baroiu Liliana and Chifiriuc Mariana Carmen and Lazar Veronica and Arbune Manuela and Coman Gigi and Draganescu Miruna},
title = {The Role of Cytokine in the Diagnosis and Monitoring of Patients with Systemic Infections},
journal = {Revista de Chimie},
volume = {71},
number = {7},
pages = {455-463},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.7.8263},
url = {https://revistadechimie.ro/Articles.asp?ID=8263}
}

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