Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage  Knee Osteoarthritis

Ionitescu, Marius; Vermesan, Dinu; Suciu, Oana; Deleanu, Bogdan; Abu-Awwad, Ahmed; Dumitrascu, Victor Cristian; Negrea, Romeo; Fruja, Dan

Marius Ionitescu, Dinu Vermesan, Oana Suciu, Bogdan Deleanu, Ahmed Abu-Awwad, Victor Cristian Dumitrascu, Romeo Negrea, Dan Fruja

Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage Knee Osteoarthritis

Abstract:

The aim of the article was to determine the association between neutrophil to lymphocyte-ratio (NLR), clinical disease severity and joint effusion in patients with early knee osteoarthritis. We evaluated 79 patients with mild knee degeneration. We obtained NLR from routine hematology panels. As controls, 1260 hematology panels were also obtained. Clinical severity was evaluated from patient reported outcome scores: International Knee Documentation Committee Subjective Knee Evaluation Form, Knee Disability And Osteoarthritis Outcome Score For Joint Replacement, Tegner-Lysholm scale and Euroqol EQ-5D-5L questionnaire. Joint effusion was determined by ultrasound. For the statistics software R, version 3.4.4 was used. There were differences in demographics but not in NLR between the study patients and controls (2.03 versus 1.98, p=0.606). There was no correlation between NLR and joint effusion (r2= - 0.121) or between NLR, joint effusion and any other parameter recorded (r2 from - 0.134 to 0.190). In the multiple regression model, NLR was minimally influenced by age (p=0.059) and KOOSJR (p=0.023). Neutrophil to lymphocyte ratio is within normal limits in patients with early stage knee osteoarthritis and is not associated with clinical severity or with joint effusion.

Keywords:
knee joint; osteoarthritis; ultrasonography; neutrophil to lymphocyte ratio; patient reported outcome measures

Issue: 2020, Volume 71, Issue 7

Pages: 464-468

Publication date: 2020/8/4

https://doi.org/10.37358/RC.20.7.8264

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IONITESCU, M., VERMESAN, D., SUCIU, O., DELEANU, B., ABU-AWWAD, A., DUMITRASCU, V.C., NEGREA, R., FRUJA, D., Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage Knee Osteoarthritis, Rev. Chim., 71(7), 2020, 464-468.

Vancouver
Ionitescu M, Vermesan D, Suciu O, Deleanu B, Abu-Awwad A, Dumitrascu VC, Negrea R, Fruja D. Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage Knee Osteoarthritis. Rev. Chim.[internet]. 2020 Jul;71(7):464-468. Available from: https://doi.org/10.37358/RC.20.7.8264

APA 6th edition
Ionitescu, M., Vermesan, D., Suciu, O., Deleanu, B., Abu-Awwad, A., Dumitrascu, V.C., Negrea, R. & Fruja, D. (2020). Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage Knee Osteoarthritis. Revista de Chimie, 71(7), 464-468. https://doi.org/10.37358/RC.20.7.8264

Harvard
Ionitescu, M., Vermesan, D., Suciu, O., Deleanu, B., Abu-Awwad, A., Dumitrascu, V.C., Negrea, R., Fruja, D. (2020). 'Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage Knee Osteoarthritis', Revista de Chimie, 71(7), pp. 464-468. https://doi.org/10.37358/RC.20.7.8264

IEEE
M. Ionitescu, D. Vermesan, O. Suciu, B. Deleanu, A. Abu-Awwad, V.C. Dumitrascu, R. Negrea, D. Fruja, "Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage Knee Osteoarthritis". Revista de Chimie, vol. 71, no. 7, pp. 464-468, 2020. [online]. https://doi.org/10.37358/RC.20.7.8264

Text
Marius Ionitescu, Dinu Vermesan, Oana Suciu, Bogdan Deleanu, Ahmed Abu-Awwad, Victor Cristian Dumitrascu, Romeo Negrea, Dan Fruja,
Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage Knee Osteoarthritis,
Revista de Chimie,
Volume 71, Issue 7,
2020,
Pages 464-468,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.7.8264.
(https://revistadechimie.ro/Articles.asp?ID=8264)
Keywords: knee joint; osteoarthritis; ultrasonography; neutrophil to lymphocyte ratio; patient reported outcome measures

RIS
TY - JOUR
T1 - Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage Knee Osteoarthritis
A1 - Ionitescu, Marius
A2 - Vermesan, Dinu
A3 - Suciu, Oana
A4 - Deleanu, Bogdan
A5 - Abu-Awwad, Ahmed
A6 - Dumitrascu, Victor Cristian
A7 - Negrea, Romeo
A8 - Fruja, Dan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 7
SP - 464
EP - 468
UR - https://doi.org/10.37358/RC.20.7.8264
KW - knee joint
KW - osteoarthritis
KW - ultrasonography
KW - neutrophil to lymphocyte ratio
KW - patient reported outcome measures
ER -

BibTex
@article{RevCh2020P464,
author = {Ionitescu Marius and Vermesan Dinu and Suciu Oana and Deleanu Bogdan and Abu-Awwad Ahmed and Dumitrascu Victor Cristian and Negrea Romeo and Fruja Dan},
title = {Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage Knee Osteoarthritis},
journal = {Revista de Chimie},
volume = {71},
number = {7},
pages = {464-468},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.7.8264},
url = {https://revistadechimie.ro/Articles.asp?ID=8264}
}

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