Diagnostic Role of Saliva in Oral Cancers

Radulescu, Radu; Greabu, Maria; Totan, Alexandra; Imre, Marina Melescanu; Miricescu, Daniela; Didilescu, Andreea; Sfeatcu, Ruxandra; Totan, Cosmin

Radu Radulescu, Maria Greabu, Alexandra Totan, Marina Melescanu Imre, Daniela Miricescu, Andreea Didilescu, Ruxandra Sfeatcu, Cosmin Totan

Diagnostic Role of Saliva in Oral Cancers

Abstract:

Saliva is a noninvasive diagnostic fluid alternative containing almost all the compounds found in blood, oral and tumoral cells. The aim of this study is to analyze the correlations occurred between different key biomarkers involved in different stages of oral cancer, such as inflammation markers - interleukin 6 (IL-6), extracellular collagen degradation markers - matrix metalloprotease 9 (MMP-9) and tissue inhibitors of metalloprotease 2 (TIMP-2).This study included a lot of 30 patients diagnosed with oral cancer at the Department of Oro Maxillo-Facial Surgery, University Hospital of Dental Medicine Prof. Dr. Dan Teodorescu. The patients were included in this study after informed consent was obtained. Salivary biomarker analysis was made using ELISA methods, biochemical or colorimetric assays. Uric acid (UA) levels were positively correlated with total antioxidant capacity (TAC) levels (r = 0.78). TAC levels were negatively correlated with IL-6 levels (r = -0.66). MMP-9 levels were positively correlated with the Ki-67protein (also known as MKI67) levels (r = 0.65) and negatively correlated with TIMP-2 levels (r = -0.71). We can conclude upon the results that salivary research may lead to the usage of saliva as a quick and reliable screening and diagnostic tool for oral cancer.

Keywords:
oral cancer; saliva; oxidative stress

Issue: 2020, Volume 71, Issue 7

Pages: 474-480

Publication date: 2020/8/4

https://doi.org/10.37358/RC.20.7.8266

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
RADULESCU, R., GREABU, M., TOTAN, A., IMRE, M.M., MIRICESCU, D., DIDILESCU, A., SFEATCU, R., TOTAN, C., Diagnostic Role of Saliva in Oral Cancers, Rev. Chim., 71(7), 2020, 474-480.

Vancouver
Radulescu R, Greabu M, Totan A, Imre MM, Miricescu D, Didilescu A, Sfeatcu R, Totan C. Diagnostic Role of Saliva in Oral Cancers. Rev. Chim.[internet]. 2020 Jul;71(7):474-480. Available from: https://doi.org/10.37358/RC.20.7.8266

APA 6th edition
Radulescu, R., Greabu, M., Totan, A., Imre, M.M., Miricescu, D., Didilescu, A., Sfeatcu, R. & Totan, C. (2020). Diagnostic Role of Saliva in Oral Cancers. Revista de Chimie, 71(7), 474-480. https://doi.org/10.37358/RC.20.7.8266

Harvard
Radulescu, R., Greabu, M., Totan, A., Imre, M.M., Miricescu, D., Didilescu, A., Sfeatcu, R., Totan, C. (2020). 'Diagnostic Role of Saliva in Oral Cancers', Revista de Chimie, 71(7), pp. 474-480. https://doi.org/10.37358/RC.20.7.8266

IEEE
R. Radulescu, M. Greabu, A. Totan, M.M. Imre, D. Miricescu, A. Didilescu, R. Sfeatcu, C. Totan, "Diagnostic Role of Saliva in Oral Cancers". Revista de Chimie, vol. 71, no. 7, pp. 474-480, 2020. [online]. https://doi.org/10.37358/RC.20.7.8266

Text
Radu Radulescu, Maria Greabu, Alexandra Totan, Marina Melescanu Imre, Daniela Miricescu, Andreea Didilescu, Ruxandra Sfeatcu, Cosmin Totan,
Diagnostic Role of Saliva in Oral Cancers,
Revista de Chimie,
Volume 71, Issue 7,
2020,
Pages 474-480,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.7.8266.
(https://revistadechimie.ro/Articles.asp?ID=8266)
Keywords: oral cancer; saliva; oxidative stress

RIS
TY - JOUR
T1 - Diagnostic Role of Saliva in Oral Cancers
A1 - Radulescu, Radu
A2 - Greabu, Maria
A3 - Totan, Alexandra
A4 - Imre, Marina Melescanu
A5 - Miricescu, Daniela
A6 - Didilescu, Andreea
A7 - Sfeatcu, Ruxandra
A8 - Totan, Cosmin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 7
SP - 474
EP - 480
UR - https://doi.org/10.37358/RC.20.7.8266
KW - oral cancer
KW - saliva
KW - oxidative stress
ER -

BibTex
@article{RevCh2020P474,
author = {Radulescu Radu and Greabu Maria and Totan Alexandra and Imre Marina Melescanu and Miricescu Daniela and Didilescu Andreea and Sfeatcu Ruxandra and Totan Cosmin},
title = {Diagnostic Role of Saliva in Oral Cancers},
journal = {Revista de Chimie},
volume = {71},
number = {7},
pages = {474-480},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.7.8266},
url = {https://revistadechimie.ro/Articles.asp?ID=8266}
}

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