ABOUT INDEXING BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER AUTHOR'S PAGE NEWS, EVENTS CONTACT
REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

REVISTA DE CHIMIE Latest Issue

LATEST ISSUE >>>

   Volume 75, 2024
   Volume 74, 2023
   Volume 73, 2022
   Volume 72, 2021
   Volume 71, 2020
   Volume 70, 2019
   Volume 69, 2018
   Volume 68, 2017
   Volume 67, 2016
   Volume 66, 2015
   Volume 65, 2014
   Volume 64, 2013
   Volume 63, 2012
   Volume 62, 2011
   Volume 61, 2010
   Volume 60, 2009
   Volume 59, 2008
   Volume 58, 2007
 
<<<< back

Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 8, 55-62

https://doi.org/10.37358/RC.20.8.8278

Andrey Gurin, Yelena Chakrova, Ilona Matveyeva, Patrick Riss

Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA

Abstract:

The article provides a comparison of the theoretically calculated and experimentally determined yield of the reaction 176Lu (n, ¦A)177Lu. Also, it provides the results of the studies on lutetium-177 labeling of a non-peptide antagonist of gonadotropin-releasing hormone (GnRH) elagolix (ELA) associated with a chelating DOTA (DOTAELA). The synthesized DOTAELA complex was labeled with the 177Lu isotope.177Lu was produced by the reaction (n, ¦A) using the enriched LuCl3 target at the reactor WWR¨CK. Production of 177Lu by the (n, ¦A) reaction from the enriched 176Lu target achieved by irradiation for 17 days. All stages of the complex preparation were evaluated by paper chromatography. The optimal technological parameters for the synthesis of the complex 177Lu-DOTAELA are: pH - 4.5, 90-100 ¡aC and 40 min. The obtained optimal parameters made it possible to produce a labeled complex of 177Lu¨CDOTAELA with a radiochemical yield of ¡Y 95%.
Keywords:
Lutetium-177; DOTAELA; labeling; radiochemical purity (RCP); triple-negative breast cancer

Issue: 2020, Volume 71, Issue 8
Pages: 55-62
Publication date: 2020/8/31
https://doi.org/10.37358/RC.20.8.8278
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
GURIN, A., CHAKROVA, Y., MATVEYEVA, I., RISS, P., Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA, Rev. Chim., 71(8), 2020, 55-62.

Vancouver
Gurin A, Chakrova Y, Matveyeva I, Riss P. Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA. Rev. Chim.[internet]. 2020 Aug;71(8):55-62. Available from: https://doi.org/10.37358/RC.20.8.8278


APA 6th edition
Gurin, A., Chakrova, Y., Matveyeva, I. & Riss, P. (2020). Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA. Revista de Chimie, 71(8), 55-62. https://doi.org/10.37358/RC.20.8.8278


Harvard
Gurin, A., Chakrova, Y., Matveyeva, I., Riss, P. (2020). 'Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA', Revista de Chimie, 71(8), pp. 55-62. https://doi.org/10.37358/RC.20.8.8278


IEEE
A. Gurin, Y. Chakrova, I. Matveyeva, P. Riss, "Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA". Revista de Chimie, vol. 71, no. 8, pp. 55-62, 2020. [online]. https://doi.org/10.37358/RC.20.8.8278


Text
Andrey Gurin, Yelena Chakrova, Ilona Matveyeva, Patrick Riss,
Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA,
Revista de Chimie,
Volume 71, Issue 8,
2020,
Pages 55-62,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.8.8278.
(https://revistadechimie.ro/Articles.asp?ID=8278)
Keywords: Lutetium-177; DOTAELA; labeling; radiochemical purity (RCP); triple-negative breast cancer


RIS
TY - JOUR
T1 - Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA
A1 - Gurin, Andrey
A2 - Chakrova, Yelena
A3 - Matveyeva, Ilona
A4 - Riss, Patrick
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 8
SP - 55
EP - 62
UR - https://doi.org/10.37358/RC.20.8.8278
KW - Lutetium-177; DOTAELA; labeling; radiochemical purity (RCP); triple-negative breast cancer
ER -


BibTex
@article{RevCh2020P55,
author = {Gurin Andrey and Chakrova Yelena and Matveyeva Ilona and Riss Patrick},
title = {Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA},
journal = {Revista de Chimie},
volume = {71},
number = {8},
pages = {55-62},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.8.8278},
url = {https://revistadechimie.ro/Articles.asp?ID=8278}
}
 
<<<< back
 
PUBLISHING SECTION
Author Guidelines
 * Paper Drafting
 * Paper Template
 * Ethical Statement
 * Paper Submission
Ghidul Autorului (ro)
Submit Paper
Author's Page
Publishing Ethics
Peer Review Process
Open Access & Archiving Policy
 Search Authors
 LATEST NEWS
REvista de Chimie NUMAR OMAGIAL PETRU PONI.. detalii
REvista de Chimie Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
dictionar English-Romanian Dictionary for Mechanical Engineering
(download pdf)
  News, Events
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License
 Conferences of Contemporary
 Chemistry
 Biblioteca Chimiei
 Materiale Plastice