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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 8, 55-62

https://doi.org/10.37358/RC.20.8.8278

Andrey Gurin, Yelena Chakrova, Ilona Matveyeva, Patrick Riss

Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA

Abstract:

The article provides a comparison of the theoretically calculated and experimentally determined yield of the reaction 176Lu (n, ¦A)177Lu. Also, it provides the results of the studies on lutetium-177 labeling of a non-peptide antagonist of gonadotropin-releasing hormone (GnRH) elagolix (ELA) associated with a chelating DOTA (DOTAELA). The synthesized DOTAELA complex was labeled with the 177Lu isotope.177Lu was produced by the reaction (n, ¦A) using the enriched LuCl3 target at the reactor WWR¨CK. Production of 177Lu by the (n, ¦A) reaction from the enriched 176Lu target achieved by irradiation for 17 days. All stages of the complex preparation were evaluated by paper chromatography. The optimal technological parameters for the synthesis of the complex 177Lu-DOTAELA are: pH - 4.5, 90-100 ¡aC and 40 min. The obtained optimal parameters made it possible to produce a labeled complex of 177Lu¨CDOTAELA with a radiochemical yield of ¡Y 95%.
Keywords:
Lutetium-177; DOTAELA; labeling; radiochemical purity (RCP); triple-negative breast cancer

Issue: 2020, Volume 71, Issue 8
Pages: 55-62
Publication date: 2020/8/31
https://doi.org/10.37358/RC.20.8.8278
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
GURIN, A., CHAKROVA, Y., MATVEYEVA, I., RISS, P., Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA, Rev. Chim., 71(8), 2020, 55-62.

Vancouver
Gurin A, Chakrova Y, Matveyeva I, Riss P. Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA. Rev. Chim.[internet]. 2020 Aug;71(8):55-62. Available from: https://doi.org/10.37358/RC.20.8.8278


APA 6th edition
Gurin, A., Chakrova, Y., Matveyeva, I. & Riss, P. (2020). Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA. Revista de Chimie, 71(8), 55-62. https://doi.org/10.37358/RC.20.8.8278


Harvard
Gurin, A., Chakrova, Y., Matveyeva, I., Riss, P. (2020). 'Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA', Revista de Chimie, 71(8), pp. 55-62. https://doi.org/10.37358/RC.20.8.8278


IEEE
A. Gurin, Y. Chakrova, I. Matveyeva, P. Riss, "Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA". Revista de Chimie, vol. 71, no. 8, pp. 55-62, 2020. [online]. https://doi.org/10.37358/RC.20.8.8278


Text
Andrey Gurin, Yelena Chakrova, Ilona Matveyeva, Patrick Riss,
Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA,
Revista de Chimie,
Volume 71, Issue 8,
2020,
Pages 55-62,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.8.8278.
(https://revistadechimie.ro/Articles.asp?ID=8278)
Keywords: Lutetium-177; DOTAELA; labeling; radiochemical purity (RCP); triple-negative breast cancer


RIS
TY - JOUR
T1 - Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA
A1 - Gurin, Andrey
A2 - Chakrova, Yelena
A3 - Matveyeva, Ilona
A4 - Riss, Patrick
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 8
SP - 55
EP - 62
UR - https://doi.org/10.37358/RC.20.8.8278
KW - Lutetium-177; DOTAELA; labeling; radiochemical purity (RCP); triple-negative breast cancer
ER -


BibTex
@article{RevCh2020P55,
author = {Gurin Andrey and Chakrova Yelena and Matveyeva Ilona and Riss Patrick},
title = {Optimization of Reaction Parameters for the Synthesis of 177Lu-DOTAELA},
journal = {Revista de Chimie},
volume = {71},
number = {8},
pages = {55-62},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.8.8278},
url = {https://revistadechimie.ro/Articles.asp?ID=8278}
}
 
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