The efficacy of Polyvynilpyrrolidone-Zn Gluconate and Taurine in the Prevention of Oral Mucositis in Haematological Patients

Niculita, Oana Otilia; Jercan, Cristina Georgiana; Radu, Letitia-Elena; Varady, Zsofia; Colita, Anca; Tanase, Alina Daniela; Colita, Andrei

Oana Otilia Niculita, Cristina Georgiana Jercan, Letitia-Elena Radu , Zsofia Varady, Anca Colita, Alina Daniela Tanase, Andrei Colita

The efficacy of Polyvynilpyrrolidone-Zn Gluconate and Taurine in the Prevention of Oral Mucositis in Haematological Patients

Abstract:

Oral mucositis (OM) is a significant problem in patients undergoing standard or high-dose chemotherapy and/or radiotherapy for the management of haematological disorders, associated with patient morbidity and increased resource use. The OM management relies on supportive care and symptom palliation. This study evaluates the results of Polyvynilpyrrolidone-Zn gluconate and taurine (GelX® Oral Spray) in this setting. This is an observational, retrospective study, conducted on 145 paediatric and adult patients. All patients received GelX® Oral Spray as prophylaxis for OM. The research was supported by BMG Pharma S.p.A. The prevention of OM in patients treated with GelX® Oral Spray was reached in 54 patients (37.24%), 22 adults (22.22%) and 32 children (69.56%). A total number of 52 patients (35.86%) developed severe OM when GelX® was used as preventive treatment, 40 adults (40.4%) adults and 12 children (26.08%). Grade 4 OM developed in 16 patients (11.03%), 10 adults and 1 child (68.75%) had a complete remission of OM, while 3 adults and 2 children (31.25%) had partial remission. No patient had to interrupt chemo/radiotherapy due to OM. GelX® Oral Spray was considered safe, no adverse device effect or severe adverse device effect were considered related to the use of the product. This retrospective study supports prophylactic use of GelX® Oral Spray to minimize the risk of OM secondary to chemo/radiotherapy.

Keywords:
Polyvinylpyrrolidone; Zinc gluconate; taurine; oral mucositis; chemotherapy; stem cell transplantation

Issue: 2020, Volume 71, Issue 8

Pages: 195-205

Publication date: 2020/8/31

https://doi.org/10.37358/RC.20.8.8280

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NICULITA, O.O., JERCAN, C.G., RADU, L., VARADY, Z., COLITA, A., TANASE, A.D., COLITA, A., The efficacy of Polyvynilpyrrolidone-Zn Gluconate and Taurine in the Prevention of Oral Mucositis in Haematological Patients, Rev. Chim., 71(8), 2020, 195-205.

Vancouver
Niculita OO, Jercan CG, Radu L, Varady Z, Colita A, Tanase AD, Colita A. The efficacy of Polyvynilpyrrolidone-Zn Gluconate and Taurine in the Prevention of Oral Mucositis in Haematological Patients. Rev. Chim.[internet]. 2020 Aug;71(8):195-205. Available from: https://doi.org/10.37358/RC.20.8.8280

APA 6th edition
Niculita, O.O., Jercan, C.G., Radu, L., Varady, Z., Colita, A., Tanase, A.D. & Colita, A. (2020). The efficacy of Polyvynilpyrrolidone-Zn Gluconate and Taurine in the Prevention of Oral Mucositis in Haematological Patients. Revista de Chimie, 71(8), 195-205. https://doi.org/10.37358/RC.20.8.8280

Harvard
Niculita, O.O., Jercan, C.G., Radu, L., Varady, Z., Colita, A., Tanase, A.D., Colita, A. (2020). 'The efficacy of Polyvynilpyrrolidone-Zn Gluconate and Taurine in the Prevention of Oral Mucositis in Haematological Patients', Revista de Chimie, 71(8), pp. 195-205. https://doi.org/10.37358/RC.20.8.8280

IEEE
O.O. Niculita, C.G. Jercan, L. Radu, Z. Varady, A. Colita, A.D. Tanase, A. Colita, "The efficacy of Polyvynilpyrrolidone-Zn Gluconate and Taurine in the Prevention of Oral Mucositis in Haematological Patients". Revista de Chimie, vol. 71, no. 8, pp. 195-205, 2020. [online]. https://doi.org/10.37358/RC.20.8.8280

Text
Oana Otilia Niculita, Cristina Georgiana Jercan, Letitia-Elena Radu, Zsofia Varady, Anca Colita, Alina Daniela Tanase, Andrei Colita,
The efficacy of Polyvynilpyrrolidone-Zn Gluconate and Taurine in the Prevention of Oral Mucositis in Haematological Patients,
Revista de Chimie,
Volume 71, Issue 8,
2020,
Pages 195-205,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.8.8280.
(https://revistadechimie.ro/Articles.asp?ID=8280)
Keywords: Polyvinylpyrrolidone; Zinc gluconate; taurine; oral mucositis; chemotherapy; stem cell transplantation

RIS
TY - JOUR
T1 - The efficacy of Polyvynilpyrrolidone-Zn Gluconate and Taurine in the Prevention of Oral Mucositis in Haematological Patients
A1 - Niculita, Oana Otilia
A2 - Jercan, Cristina Georgiana
A3 - Radu, Letitia-Elena
A4 - Varady, Zsofia
A5 - Colita, Anca
A6 - Tanase, Alina Daniela
A7 - Colita, Andrei
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 8
SP - 195
EP - 205
UR - https://doi.org/10.37358/RC.20.8.8280
KW - Polyvinylpyrrolidone
KW - Zinc gluconate
KW - taurine
KW - oral mucositis
KW - chemotherapy
KW - stem cell transplantation
ER -

BibTex
@article{RevCh2020P195,
author = {Niculita Oana Otilia and Jercan Cristina Georgiana and Radu Letitia-Elena and Varady Zsofia and Colita Anca and Tanase Alina Daniela and Colita Andrei},
title = {The efficacy of Polyvynilpyrrolidone-Zn Gluconate and Taurine in the Prevention of Oral Mucositis in Haematological Patients},
journal = {Revista de Chimie},
volume = {71},
number = {8},
pages = {195-205},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.8.8280},
url = {https://revistadechimie.ro/Articles.asp?ID=8280}
}

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