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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 8, 292-303

https://doi.org/10.37358/RC.20.8.8302

Madalina Preda, Alina-Alexandra Serbanescu, Mara Madalina Mihai, Gabriela-Loredana Popa, Loredana Cornelia Sabina Manolescu, Mircea-Ioan Popa

The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine

Abstract:

Staphylococcus spp. is a facultative pathogen, which can be found in the commensal microbiota of humans, most often in moist skinfolds and mucous membranes. This microorganism has the ability to cause various infections, in almost every organ of the body, with an increased frequency in the skin and soft tissues, being involved in pathologies like acne, folliculitis, furunculosis, hidradenitis suppurativa, cellulitis, abscesses, but also in secondary infections in diseases with an altered cutaneous barrier. The prolonged evolution of these diseases and severe outcome can be influenced by various factors, most importantly being the antimicrobial resistance. We have evaluated the antimicrobial susceptibility profiles, according to the Comite de l' Antibiogramme de la Societe Francaise de Microbiologie recommendations, for strains of Staphylococcus spp. isolated from acne or different types of skin and soft tissue infections in patients recommended to receive autologous bacterial vaccine. Most frequent identified species was Staphylococcus epidermidis, followed by Staphylococcus aureus. The antimicrobial resistance was higher for antibiotics usually used in the treatment of skin and soft tissue infections, with interesting differences of the resistance profile for the strains isolated from patients before receiving autologous bacterial vaccine compared with the ones from individuals already treated. Another important finding was represented by the differences in the resistance profile according to the age group of the patients. The results of this study underline the importance of antimicrobial resistance surveillance in finding new molecules and alternative therapies, the necessity of a personalized approach in medical acts and of a continuous connection between clinic and laboratory research.
Keywords:
Staphylococcus spp.; antimicrobial resistance; autovaccine; antibiotics development

Issue: 2020, Volume 71, Issue 8
Pages: 292-303
Publication date: 2020/8/31
https://doi.org/10.37358/RC.20.8.8302
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
PREDA, M., SERBANESCU, A., MIHAI, M.M., POPA, G., MANOLESCU, L.C.S., POPA, M., The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine, Rev. Chim., 71(8), 2020, 292-303.

Vancouver
Preda M, Serbanescu A, Mihai MM, Popa G, Manolescu LCS, Popa M. The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine. Rev. Chim.[internet]. 2020 Aug;71(8):292-303. Available from: https://doi.org/10.37358/RC.20.8.8302


APA 6th edition
Preda, M., Serbanescu, A., Mihai, M.M., Popa, G., Manolescu, L.C.S. & Popa, M. (2020). The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine. Revista de Chimie, 71(8), 292-303. https://doi.org/10.37358/RC.20.8.8302


Harvard
Preda, M., Serbanescu, A., Mihai, M.M., Popa, G., Manolescu, L.C.S., Popa, M. (2020). 'The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine', Revista de Chimie, 71(8), pp. 292-303. https://doi.org/10.37358/RC.20.8.8302


IEEE
M. Preda, A. Serbanescu, M.M. Mihai, G. Popa, L.C.S. Manolescu, M. Popa, "The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine". Revista de Chimie, vol. 71, no. 8, pp. 292-303, 2020. [online]. https://doi.org/10.37358/RC.20.8.8302


Text
Madalina Preda, Alina-Alexandra Serbanescu, Mara Madalina Mihai, Gabriela-Loredana Popa, Loredana Cornelia Sabina Manolescu, Mircea-Ioan Popa,
The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine,
Revista de Chimie,
Volume 71, Issue 8,
2020,
Pages 292-303,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.8.8302.
(https://revistadechimie.ro/Articles.asp?ID=8302)
Keywords: Staphylococcus spp.; antimicrobial resistance; autovaccine; antibiotics development


RIS
TY - JOUR
T1 - The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine
A1 - Preda, Madalina
A2 - Serbanescu, Alina-Alexandra
A3 - Mihai, Mara Madalina
A4 - Popa, Gabriela-Loredana
A5 - Manolescu, Loredana Cornelia Sabina
A6 - Popa, Mircea-Ioan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 8
SP - 292
EP - 303
UR - https://doi.org/10.37358/RC.20.8.8302
KW - Staphylococcus spp.
KW - antimicrobial resistance
KW - autovaccine
KW - antibiotics development
ER -


BibTex
@article{RevCh2020P292,
author = {Preda Madalina and Serbanescu Alina-Alexandra and Mihai Mara Madalina and Popa Gabriela-Loredana and Manolescu Loredana Cornelia Sabina and Popa Mircea-Ioan},
title = {The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine},
journal = {Revista de Chimie},
volume = {71},
number = {8},
pages = {292-303},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.8.8302},
url = {https://revistadechimie.ro/Articles.asp?ID=8302}
}
 
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