MiR-504 and miR-205 May be Used to Evaluate Prognosis and Chemotherapeutic Effect of Pancreatic Cancer Patients<br>

Wang, Le; Song, Yinghui; Liu, Sulai; Tang, Hongying; Zhang, Zhihua; Peng, Chuang; Jiang, O

Le Wang, Yinghui Song, Sulai Liu, Hongying Tang, Zhihua Zhang, Chuang Peng, O Jiang

MiR-504 and miR-205 May be Used to Evaluate Prognosis and Chemotherapeutic Effect of Pancreatic Cancer Patients

Abstract:

To explore the value of miR-504 and miR-205 in evaluating the prognosis and chemo-therapeutic effect of pancreatic cancer (PC) patients. Ninety-six PC patients who came to our hospital from March 2015 to February 2017 were selected as the research group (RG), and 96 healthy subjects during the same period were considered as the control group (CG). Serum miR-504 and miR-205 of subjects in the two groups were detected and compared by Rt-PCR, and the miR-504 and miR-205 expression levels in serum of PC patients before and after chemotherapy were analyzed, so did the relationship between miR-504, miR-205 and prognosis of patients. The miR-504 and miR-205 expression levels in serum of PC patients were dramatically higher than those of healthy people (P[ 0.05), and the expression levels in serum of those in the chemotherapy-effective group were dramatically lower than those of those in the chemotherapy-ineffective group (P[ 0.05). Moreover, the 3-year mortality of patients with high expression of miR-504 and miR-205 was higher than that of those with low expression (P[ 0.05), and the miR-504 and miR-205 expression levels in dead patients were higher than those in living patients. miR-504 and miR-205 had high predictive value for poor prognosis of PC patients. Univariate analysis identified that their poor prognosis was related to pathological stage, lymph node metastasis, differentiation degree and expression of miR-504 and miR-205 (P[ 0.05). Cox multivariate analysis identified that pathological stage, lymph node metastasis, differentiation degree and expression of miR-504 and miR-205 were independent risk factors for poor prognosis (P[ 0.05).DLX6-AS1 is highly expressed in the serum of PC patients, and it can evaluate the chemotherapeutic effect and predict the prognosis. So, it may be used as a new target direction for evaluating the chemotherapeutic effect and predicting the prognosis of patients.

Keywords:
miR-504; miR-205; pancreatic cancer; expression; prognosis; chemotherapeutic effect

Issue: 2020, Volume 71, Issue 8

Pages: 335-343

Publication date: 2020/8/31

https://doi.org/10.37358/RC.20.8.8307

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
WANG, L., SONG, Y., LIU, S., TANG, H., ZHANG, Z., PENG, C., JIANG, O., MiR-504 and miR-205 May be Used to Evaluate Prognosis and Chemotherapeutic Effect of Pancreatic Cancer Patients
, Rev. Chim., 71(8), 2020, 335-343.

Vancouver
Wang L, Song Y, Liu S, Tang H, Zhang Z, Peng C, Jiang O. MiR-504 and miR-205 May be Used to Evaluate Prognosis and Chemotherapeutic Effect of Pancreatic Cancer Patients
. Rev. Chim.[internet]. 2020 Aug;71(8):335-343. Available from: https://doi.org/10.37358/RC.20.8.8307

APA 6th edition
Wang, L., Song, Y., Liu, S., Tang, H., Zhang, Z., Peng, C. & Jiang, O. (2020). MiR-504 and miR-205 May be Used to Evaluate Prognosis and Chemotherapeutic Effect of Pancreatic Cancer Patients
. Revista de Chimie, 71(8), 335-343. https://doi.org/10.37358/RC.20.8.8307

Harvard
Wang, L., Song, Y., Liu, S., Tang, H., Zhang, Z., Peng, C., Jiang, O. (2020). 'MiR-504 and miR-205 May be Used to Evaluate Prognosis and Chemotherapeutic Effect of Pancreatic Cancer Patients
', Revista de Chimie, 71(8), pp. 335-343. https://doi.org/10.37358/RC.20.8.8307

IEEE
L. Wang, Y. Song, S. Liu, H. Tang, Z. Zhang, C. Peng, O. Jiang, "MiR-504 and miR-205 May be Used to Evaluate Prognosis and Chemotherapeutic Effect of Pancreatic Cancer Patients
". Revista de Chimie, vol. 71, no. 8, pp. 335-343, 2020. [online]. https://doi.org/10.37358/RC.20.8.8307

Text
Le Wang, Yinghui Song, Sulai Liu, Hongying Tang, Zhihua Zhang, Chuang Peng, O Jiang,
MiR-504 and miR-205 May be Used to Evaluate Prognosis and Chemotherapeutic Effect of Pancreatic Cancer Patients
,
Revista de Chimie,
Volume 71, Issue 8,
2020,
Pages 335-343,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.8.8307.
(https://revistadechimie.ro/Articles.asp?ID=8307)
Keywords: miR-504; miR-205; pancreatic cancer; expression; prognosis; chemotherapeutic effect

RIS
TY - JOUR
T1 - MiR-504 and miR-205 May be Used to Evaluate Prognosis and Chemotherapeutic Effect of Pancreatic Cancer Patients

A1 - Wang, Le
A2 - Song, Yinghui
A3 - Liu, Sulai
A4 - Tang, Hongying
A5 - Zhang, Zhihua
A6 - Peng, Chuang
A7 - Jiang, O
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 8
SP - 335
EP - 343
UR - https://doi.org/10.37358/RC.20.8.8307
KW - miR-504
KW - miR-205
KW - pancreatic cancer
KW - expression
KW - prognosis
KW - chemotherapeutic effect
ER -

BibTex
@article{RevCh2020P335,
author = {Wang Le and Song Yinghui and Liu Sulai and Tang Hongying and Zhang Zhihua and Peng Chuang and Jiang O},
title = {MiR-504 and miR-205 May be Used to Evaluate Prognosis and Chemotherapeutic Effect of Pancreatic Cancer Patients
},
journal = {Revista de Chimie},
volume = {71},
number = {8},
pages = {335-343},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.8.8307},
url = {https://revistadechimie.ro/Articles.asp?ID=8307}
}

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