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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 8, 344-352

https://doi.org/10.37358/RC.20.8.8308

Jiaqi Chen, Jianjun Tang, Chaoke Bu, Jianyun Liao, Jieming Yu, Tingting Luo, Yiqi Xv, Rongfang Ding

Analysis of Cellular and Biochemical Factors Involved in Acute Myeloid Leukemia Taking Into Account the Dysfunctional Module

Abstract:

Acute myeloid leukemia (AML) is a malignant hematological disease caused by the abnormal hematopoietic system. Its specific pathogenesis is still unclear. Therefore, we have carried out a series of related studies. Firstly, co-expression analysis of acute myeloid leukemia related genes in the Human Mendelian Genetic Database (OMIM) was carried out, and a co-expression module was constructed. Further enrichment analysis of module-related genes with Go and KEGG was carried out. Subsequently, the modules are analyzed by Crosstalk to show their interaction. Also, pivot prediction is used to identify critical factors in the regulatory module and potential target drugs. Results A total of 14 co-expression modules were obtained, which were found to be significantly involved in cell proliferation and apoptosis, Ras and Wnt signaling pathways. The modules with higher connectivity (UBB, RAC1, TP53, PIK3CA) were also counted. Also, it is found that there is significant crosstalk between these modules. On the other hand, we screened 2815 drivers of regulatory modules, including TP53, E2F1, MYC-based transcription factors, and non-coding RNA (ncRNA) dominated by microRNA-320a, microRNA-193b-3p, and microRNA-93-5p. Finally, many regulatory drugs (Copper, Artenimol, Indomethacin, etc.) with targeted pathogenic genes were predicted. Overall, this study explores the underlying pathogenesis of acute myeloid leukemia and predicts the related regulatory drugs. The results of this study provide a new method and theoretical basis for follow-up mechanism research and treatment strategy.
Keywords:
dysfunction module; acute myeloid leukemia; KEG

Issue: 2020, Volume 71, Issue 8
Pages: 344-352
Publication date: 2020/8/31
https://doi.org/10.37358/RC.20.8.8308
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
CHEN, J., TANG, J., BU, C., LIAO, J., YU, J., LUO, T., XV, Y., DING, R., Analysis of Cellular and Biochemical Factors Involved in Acute Myeloid Leukemia Taking Into Account the Dysfunctional Module, Rev. Chim., 71(8), 2020, 344-352.

Vancouver
Chen J, Tang J, Bu C, Liao J, Yu J, Luo T, Xv Y, Ding R. Analysis of Cellular and Biochemical Factors Involved in Acute Myeloid Leukemia Taking Into Account the Dysfunctional Module. Rev. Chim.[internet]. 2020 Aug;71(8):344-352. Available from: https://doi.org/10.37358/RC.20.8.8308


APA 6th edition
Chen, J., Tang, J., Bu, C., Liao, J., Yu, J., Luo, T., Xv, Y. & Ding, R. (2020). Analysis of Cellular and Biochemical Factors Involved in Acute Myeloid Leukemia Taking Into Account the Dysfunctional Module. Revista de Chimie, 71(8), 344-352. https://doi.org/10.37358/RC.20.8.8308


Harvard
Chen, J., Tang, J., Bu, C., Liao, J., Yu, J., Luo, T., Xv, Y., Ding, R. (2020). 'Analysis of Cellular and Biochemical Factors Involved in Acute Myeloid Leukemia Taking Into Account the Dysfunctional Module', Revista de Chimie, 71(8), pp. 344-352. https://doi.org/10.37358/RC.20.8.8308


IEEE
J. Chen, J. Tang, C. Bu, J. Liao, J. Yu, T. Luo, Y. Xv, R. Ding, "Analysis of Cellular and Biochemical Factors Involved in Acute Myeloid Leukemia Taking Into Account the Dysfunctional Module". Revista de Chimie, vol. 71, no. 8, pp. 344-352, 2020. [online]. https://doi.org/10.37358/RC.20.8.8308


Text
Jiaqi Chen, Jianjun Tang, Chaoke Bu, Jianyun Liao, Jieming Yu, Tingting Luo, Yiqi Xv, Rongfang Ding,
Analysis of Cellular and Biochemical Factors Involved in Acute Myeloid Leukemia Taking Into Account the Dysfunctional Module,
Revista de Chimie,
Volume 71, Issue 8,
2020,
Pages 344-352,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.8.8308.
(https://revistadechimie.ro/Articles.asp?ID=8308)
Keywords: dysfunction module; acute myeloid leukemia; KEG


RIS
TY - JOUR
T1 - Analysis of Cellular and Biochemical Factors Involved in Acute Myeloid Leukemia Taking Into Account the Dysfunctional Module
A1 - Chen, Jiaqi
A2 - Tang, Jianjun
A3 - Bu, Chaoke
A4 - Liao, Jianyun
A5 - Yu, Jieming
A6 - Luo, Tingting
A7 - Xv, Yiqi
A8 - Ding, Rongfang
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 8
SP - 344
EP - 352
UR - https://doi.org/10.37358/RC.20.8.8308
KW - dysfunction module
KW - acute myeloid leukemia
KW - KEG
ER -


BibTex
@article{RevCh2020P344,
author = {Chen Jiaqi and Tang Jianjun and Bu Chaoke and Liao Jianyun and Yu Jieming and Luo Tingting and Xv Yiqi and Ding Rongfang},
title = {Analysis of Cellular and Biochemical Factors Involved in Acute Myeloid Leukemia Taking Into Account the Dysfunctional Module},
journal = {Revista de Chimie},
volume = {71},
number = {8},
pages = {344-352},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.8.8308},
url = {https://revistadechimie.ro/Articles.asp?ID=8308}
}
 
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