Synthesis of Poly (Styrene Sulfonate) Coated Gd3+ Poly (Lactide-Co-Glycolic Acid) Perfluoro Bromide Nanoparticles for Stem Cell Monitoring Using Magnetic Resonance Imaging

Vu-Quang, Hieu; Nguyen, Thanh-Quang; Vinding, Mads Sloth

Hieu Vu-Quang, Thanh-Quang Nguyen, Mads Sloth Vinding

Synthesis of Poly (Styrene Sulfonate) Coated Gd3+ Poly (Lactide-Co-Glycolic Acid) Perfluoro Bromide Nanoparticles for Stem Cell Monitoring Using Magnetic Resonance Imaging

Abstract:

Magnetic resonance imaging (MRI) is one of best imaging technologies to monitor transplanted stem cells, because of its high anatomical resolution and safety. In this study, we aim to synthesize Poly (styrene sulphonate) coated Gd3+ - Poly (lactide co glycolic acid) Perfluorooctyl Bromide nanoparticles (PSS-coated Gd3+@NPs) for stem cell labeling using both 1H and 19F MRI. At a weight ratio 20 of PLGA/ Gd3+, NPs have a spherical shape with the hydrodynamic size at 180 nm with zeta potential at -53 mV. In vitro, we obtain the intended T1 relaxation acceleration of water on 1H MRI. The NPs have low toxicity to the human mesenchymal stem cells (hMSC) up to 1 mg/ml. They could internalize into the stem cells via caveolae-mediated endocytosis efficiently, confirmed by flow cytometry analysis, and gives a good contrast in both channels 1H and 18F MRI scans. In conclusion, our NPs have shown a great potential as a dual-contrast agent in MRI for stem cell monitoring.

Keywords:
MRI contrast agent; gadolinium; perfluoroocctyl bromide; stem cell monitoring

Issue: 2020, Volume 71, Issue 9

Pages: 77-86

Publication date: 2020/9/5

https://doi.org/10.37358/RC.20.9.8319

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
VU-QUANG, H., NGUYEN, T., VINDING, M.S., Synthesis of Poly (Styrene Sulfonate) Coated Gd3+ Poly (Lactide-Co-Glycolic Acid) Perfluoro Bromide Nanoparticles for Stem Cell Monitoring Using Magnetic Resonance Imaging, Rev. Chim., 71(9), 2020, 77-86.

Vancouver
Vu-Quang H, Nguyen T, Vinding MS. Synthesis of Poly (Styrene Sulfonate) Coated Gd3+ Poly (Lactide-Co-Glycolic Acid) Perfluoro Bromide Nanoparticles for Stem Cell Monitoring Using Magnetic Resonance Imaging. Rev. Chim.[internet]. 2020 Sep;71(9):77-86. Available from: https://doi.org/10.37358/RC.20.9.8319

APA 6th edition
Vu-Quang, H., Nguyen, T. & Vinding, M.S. (2020). Synthesis of Poly (Styrene Sulfonate) Coated Gd3+ Poly (Lactide-Co-Glycolic Acid) Perfluoro Bromide Nanoparticles for Stem Cell Monitoring Using Magnetic Resonance Imaging. Revista de Chimie, 71(9), 77-86. https://doi.org/10.37358/RC.20.9.8319

Harvard
Vu-Quang, H., Nguyen, T., Vinding, M.S. (2020). 'Synthesis of Poly (Styrene Sulfonate) Coated Gd3+ Poly (Lactide-Co-Glycolic Acid) Perfluoro Bromide Nanoparticles for Stem Cell Monitoring Using Magnetic Resonance Imaging', Revista de Chimie, 71(9), pp. 77-86. https://doi.org/10.37358/RC.20.9.8319

IEEE
H. Vu-Quang, T. Nguyen, M.S. Vinding, "Synthesis of Poly (Styrene Sulfonate) Coated Gd3+ Poly (Lactide-Co-Glycolic Acid) Perfluoro Bromide Nanoparticles for Stem Cell Monitoring Using Magnetic Resonance Imaging". Revista de Chimie, vol. 71, no. 9, pp. 77-86, 2020. [online]. https://doi.org/10.37358/RC.20.9.8319

Text
Hieu Vu-Quang, Thanh-Quang Nguyen, Mads Sloth Vinding,
Synthesis of Poly (Styrene Sulfonate) Coated Gd3+ Poly (Lactide-Co-Glycolic Acid) Perfluoro Bromide Nanoparticles for Stem Cell Monitoring Using Magnetic Resonance Imaging,
Revista de Chimie,
Volume 71, Issue 9,
2020,
Pages 77-86,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.9.8319.
(https://revistadechimie.ro/Articles.asp?ID=8319)
Keywords: MRI contrast agent; gadolinium; perfluoroocctyl bromide; stem cell monitoring

RIS
TY - JOUR
T1 - Synthesis of Poly (Styrene Sulfonate) Coated Gd3+ Poly (Lactide-Co-Glycolic Acid) Perfluoro Bromide Nanoparticles for Stem Cell Monitoring Using Magnetic Resonance Imaging
A1 - Vu-Quang, Hieu
A2 - Nguyen, Thanh-Quang
A3 - Vinding, Mads Sloth
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 9
SP - 77
EP - 86
UR - https://doi.org/10.37358/RC.20.9.8319
KW - MRI contrast agent
KW - gadolinium
KW - perfluoroocctyl bromide
KW - stem cell monitoring
ER -

BibTex
@article{RevCh2020P77,
author = {Vu-Quang Hieu and Nguyen Thanh-Quang and Vinding Mads Sloth},
title = {Synthesis of Poly (Styrene Sulfonate) Coated Gd3+ Poly (Lactide-Co-Glycolic Acid) Perfluoro Bromide Nanoparticles for Stem Cell Monitoring Using Magnetic Resonance Imaging},
journal = {Revista de Chimie},
volume = {71},
number = {9},
pages = {77-86},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.9.8319},
url = {https://revistadechimie.ro/Articles.asp?ID=8319}
}

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