Molecular Subgroups of Endometrial Carcinoma in Romanian Patients

Evsei, Anca; Birceanu-Corobea, Adelina; Csonka, Tamas; Copca, Narcis; Sajin, Maria

Anca Evsei, Adelina Birceanu-Corobea, Tamas Csonka, Narcis Copca, Maria Sajin

Molecular Subgroups of Endometrial Carcinoma in Romanian Patients

Abstract:

Molecular classification of endometrial carcinoma (EC) has represented a breakthrough ever since the TCGA (The Cancer Genome Atlas) project published it in 2013. Four distinct molecular subgroups were recognized based on somatic copy number alterations and tumor mutational burden: POLE (polymerase-epsilon) ultramutated, MSI (microsatellite instability) hypermutated (MSI-H), copy number low (CNL) and copy number high (CNH). However, implementing a standardized algorithm in current practice is far from being definitive. Our purpose in this study was to determine different molecular subgroups in a cohort of Romanian patients using cost effective and available immuno-histochemistry markers and outline statistical associations with different parameters. Tissue microarrays encompassing 50 cases with previously diagnosed ECs were tested for ER, PR, HER2, p53, MSH6 and PMS2 and results showed 68% MSI-H cases with statistical correlation with tumor size ] 2 cm (p=0.028) and no association with overall survival. CNH ECs were reported in 26% of cases and showed important statistical significance with TILs (p=0.041) and no correlations with overall survival. The CNL subgroup was reported in 74% of ECs cases and showed statistical significance with the histopathological subtype (p=0.006), pT (removal of primary tumor according to AJCC/UICC convention) (p=0.033), risk category according to ESMO (European Society of Medical Oncology) criteria (p=0.022) and ER expression (p=0.002). Five-year overall survival was 84%. Molecular classification is an important additional tool in current pathology guidelines for reporting ECs, but it is not currently standardized or available in all laboratories. Its importance in evolving treatment strategies for this disease is well documented so we strongly recommend routine testing for molecular prognostic factors.

Keywords:
endometrial carcinoma; molecular classification; survival

Issue: 2020, Volume 71, Issue 9

Pages: 268-276

Publication date: 2020/9/5

https://doi.org/10.37358/RC.20.9.8337

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
EVSEI, A., BIRCEANU-COROBEA, A., CSONKA, T., COPCA, N., SAJIN, M., Molecular Subgroups of Endometrial Carcinoma in Romanian Patients, Rev. Chim., 71(9), 2020, 268-276.

Vancouver
Evsei A, Birceanu-Corobea A, Csonka T, Copca N, Sajin M. Molecular Subgroups of Endometrial Carcinoma in Romanian Patients. Rev. Chim.[internet]. 2020 Sep;71(9):268-276. Available from: https://doi.org/10.37358/RC.20.9.8337

APA 6th edition
Evsei, A., Birceanu-Corobea, A., Csonka, T., Copca, N. & Sajin, M. (2020). Molecular Subgroups of Endometrial Carcinoma in Romanian Patients. Revista de Chimie, 71(9), 268-276. https://doi.org/10.37358/RC.20.9.8337

Harvard
Evsei, A., Birceanu-Corobea, A., Csonka, T., Copca, N., Sajin, M. (2020). 'Molecular Subgroups of Endometrial Carcinoma in Romanian Patients', Revista de Chimie, 71(9), pp. 268-276. https://doi.org/10.37358/RC.20.9.8337

IEEE
A. Evsei, A. Birceanu-Corobea, T. Csonka, N. Copca, M. Sajin, "Molecular Subgroups of Endometrial Carcinoma in Romanian Patients". Revista de Chimie, vol. 71, no. 9, pp. 268-276, 2020. [online]. https://doi.org/10.37358/RC.20.9.8337

Text
Anca Evsei, Adelina Birceanu-Corobea, Tamas Csonka, Narcis Copca, Maria Sajin,
Molecular Subgroups of Endometrial Carcinoma in Romanian Patients,
Revista de Chimie,
Volume 71, Issue 9,
2020,
Pages 268-276,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.9.8337.
(https://revistadechimie.ro/Articles.asp?ID=8337)
Keywords: endometrial carcinoma; molecular classification; survival

RIS
TY - JOUR
T1 - Molecular Subgroups of Endometrial Carcinoma in Romanian Patients
A1 - Evsei, Anca
A2 - Birceanu-Corobea, Adelina
A3 - Csonka, Tamas
A4 - Copca, Narcis
A5 - Sajin, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 9
SP - 268
EP - 276
UR - https://doi.org/10.37358/RC.20.9.8337
KW - endometrial carcinoma
KW - molecular classification
KW - survival
ER -

BibTex
@article{RevCh2020P268,
author = {Evsei Anca and Birceanu-Corobea Adelina and Csonka Tamas and Copca Narcis and Sajin Maria},
title = {Molecular Subgroups of Endometrial Carcinoma in Romanian Patients},
journal = {Revista de Chimie},
volume = {71},
number = {9},
pages = {268-276},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.9.8337},
url = {https://revistadechimie.ro/Articles.asp?ID=8337}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)