New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand

Reiss, Aurora; Mitran, Raul-Augustin; Babeanu, Cristina; Amzoiu, Emilia; Amzoiu, Manuel Ovidiu; Varut, Renata Maria; Ganescu, Anca

Aurora Reiss, Raul-Augustin Mitran, Cristina Babeanu, Emilia Amzoiu, Manuel Ovidiu Amzoiu, Renata Maria Varut, Anca Ganescu

New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand

Abstract:

Four mixed-ligand metal(II) complexes with the molecular formulae [M(ofl)(bipy)]NO3·H2O and [M(ofl)(phen)]NO3·H2O were synthesized by the reaction of Co(II) and Ni(II) with ofloxacin (Hofl) in the presence of 1,10-phenanthroline (phen) / 2,2'-bipyridine (bipy) (1:1:1 molar ratio). The data obtained from elemental analysis, molar conductance, spectral infrared, reflectance spectra and magnetic studies gave information about the coordination of the ligands and the geometry of the metallic ion. The results suggest that Hofl is deprotonated and bidentately bound to the metal ion through the pyridone oxygen and the carboxylato oxygen while phen and bipy act as neutral bidentate ligands coordinated through the nitrogen atoms. Tetrahedral geometry is proposed for all complexes. Thermal analysis data led to useful information concerning the composition, dehydration and thermal behaviour of the complexes. Ofloxacin and the metal complexes were tested for antibacterial activity and also for antioxidant activity. The variations of physicochemical parameters were monitored, which explain the antibacterial behaviour of these compounds. The interactions between metal complexes and bacterial receptors have lower energy values compared to the ofloxacin ligand. The molecular docking studies allow the identification of the biological target and the predictions of the bonds between the studied compounds and the receptors of E. coli (3t88), S. aureus (3q8u) and P. aeruginosa (4lkd).

Keywords:
ofloxacin; mixed-ligand; metal complexes; DFT calculations; molecular docking

Issue: 2020, Volume 71, Issue 10

Pages: 11-27

Publication date: 2020/11/3

https://doi.org/10.37358/RC.20.10.8346

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Citation Styles

Cite this article as:
REISS, A., MITRAN, R., BABEANU, C., AMZOIU, E., AMZOIU, M.O., VARUT, R.M., GANESCU, A., New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand, Rev. Chim., 71(10), 2020, 11-27.

Vancouver
Reiss A, Mitran R, Babeanu C, Amzoiu E, Amzoiu MO, Varut RM, Ganescu A. New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand. Rev. Chim.[internet]. 2020 Oct;71(10):11-27. Available from: https://doi.org/10.37358/RC.20.10.8346

APA 6th edition
Reiss, A., Mitran, R., Babeanu, C., Amzoiu, E., Amzoiu, M.O., Varut, R.M. & Ganescu, A. (2020). New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand. Revista de Chimie, 71(10), 11-27. https://doi.org/10.37358/RC.20.10.8346

Harvard
Reiss, A., Mitran, R., Babeanu, C., Amzoiu, E., Amzoiu, M.O., Varut, R.M., Ganescu, A. (2020). 'New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand', Revista de Chimie, 71(10), pp. 11-27. https://doi.org/10.37358/RC.20.10.8346

IEEE
A. Reiss, R. Mitran, C. Babeanu, E. Amzoiu, M.O. Amzoiu, R.M. Varut, A. Ganescu, "New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand". Revista de Chimie, vol. 71, no. 10, pp. 11-27, 2020. [online]. https://doi.org/10.37358/RC.20.10.8346

Text
Aurora Reiss, Raul-Augustin Mitran, Cristina Babeanu, Emilia Amzoiu, Manuel Ovidiu Amzoiu, Renata Maria Varut, Anca Ganescu,
New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand,
Revista de Chimie,
Volume 71, Issue 10,
2020,
Pages 11-27,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.10.8346.
(https://revistadechimie.ro/Articles.asp?ID=8346)
Keywords: ofloxacin; mixed-ligand; metal complexes; DFT calculations; molecular docking

RIS
TY - JOUR
T1 - New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand
A1 - Reiss, Aurora
A2 - Mitran, Raul-Augustin
A3 - Babeanu, Cristina
A4 - Amzoiu, Emilia
A5 - Amzoiu, Manuel Ovidiu
A6 - Varut, Renata Maria
A7 - Ganescu, Anca
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 10
SP - 11
EP - 27
UR - https://doi.org/10.37358/RC.20.10.8346
KW - ofloxacin
KW - mixed-ligand
KW - metal complexes
KW - DFT calculations
KW - molecular docking
ER -

BibTex
@article{RevCh2020P11,
author = {Reiss Aurora and Mitran Raul-Augustin and Babeanu Cristina and Amzoiu Emilia and Amzoiu Manuel Ovidiu and Varut Renata Maria and Ganescu Anca},
title = {New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand},
journal = {Revista de Chimie},
volume = {71},
number = {10},
pages = {11-27},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.10.8346},
url = {https://revistadechimie.ro/Articles.asp?ID=8346}
}

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