Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia

Ashfaq, Muhammad; Abid, S. Mobasher Ali; Rauf, Khalid; Alkahraman, Yasser Msa; Haroon, Muhammad Zeeshan; Ahmad, Fawad; Ikram, Saima; Ahmad, Jamshaid

Muhammad Ashfaq, S. Mobasher Ali Abid, Khalid Rauf, Yasser Msa Alkahraman, Muhammad Zeeshan Haroon, Fawad Ahmad, Saima Ikram, Jamshaid Ahmad

Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia

Abstract:

Dopamine is a catecholamine neurotransmitter that control several important functions via different dopamine receptors(D1-D5). The Dopamine (DRD2) receptor and other D2 family receptors (D3 and D4) are predominantly involved in the inhibitory activities. One vital role of dopamine receptors is its involvement in the endocrine regulations including the hormone synthesis and their secretion. The regulation of prolactin hormone is mainly controlled through DRD2 receptors. Blocking the delivery of dopamine at these DRD2 receptors will cause an increase in serum prolactin levels. PPI’s are among the widely prescribed medications used for multiple gastric hypersecretory disorders and are shown to cause increase in serum prolactin level. This study focuses on computational methods to test PPIs interaction with dopamine D2 receptor through molecular docking & dynamics studies. The 3D structure of protein and the drugs were downloaded from PDB and PubChem databases. Protein and ligands were prepared followed by molecular docking. Complexes with best docking poses were then proceeded towards MD simulations of 60 ns. Results were then analyzed. This study confirmed that there is prospective affinity between proton pump inhibitors and dopamine D2 receptor, and dynamically stable complexes are formed after drug-receptor binding. MD simulations results confirmed the binding affinity between PPIs and Dopamine D2 receptor, concluding that the use of PPIs may be involved in drug induced hyperprolactinemia and other related effects.

Keywords:
Proton Pump Inhibitors; DRD2 receptor; Docking; MD Simulation; Hyperprolactinemia

Issue: 2020, Volume 71, Issue 10

Pages: 182-192

Publication date: 2020/11/3

https://doi.org/10.37358/RC.20.10.8362

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ASHFAQ, M., ABID, S.M.A., RAUF, K., ALKAHRAMAN, Y.M., HAROON, M.Z., AHMAD, F., IKRAM, S., AHMAD, J., Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia, Rev. Chim., 71(10), 2020, 182-192.

Vancouver
Ashfaq M, Abid SMA, Rauf K, Alkahraman YM, Haroon MZ, Ahmad F, Ikram S, Ahmad J. Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia. Rev. Chim.[internet]. 2020 Oct;71(10):182-192. Available from: https://doi.org/10.37358/RC.20.10.8362

APA 6th edition
Ashfaq, M., Abid, S.M.A., Rauf, K., Alkahraman, Y.M., Haroon, M.Z., Ahmad, F., Ikram, S. & Ahmad, J. (2020). Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia. Revista de Chimie, 71(10), 182-192. https://doi.org/10.37358/RC.20.10.8362

Harvard
Ashfaq, M., Abid, S.M.A., Rauf, K., Alkahraman, Y.M., Haroon, M.Z., Ahmad, F., Ikram, S., Ahmad, J. (2020). 'Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia', Revista de Chimie, 71(10), pp. 182-192. https://doi.org/10.37358/RC.20.10.8362

IEEE
M. Ashfaq, S.M.A. Abid, K. Rauf, Y.M. Alkahraman, M.Z. Haroon, F. Ahmad, S. Ikram, J. Ahmad, "Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia". Revista de Chimie, vol. 71, no. 10, pp. 182-192, 2020. [online]. https://doi.org/10.37358/RC.20.10.8362

Text
Muhammad Ashfaq, S. Mobasher Ali Abid, Khalid Rauf, Yasser Msa Alkahraman, Muhammad Zeeshan Haroon, Fawad Ahmad, Saima Ikram, Jamshaid Ahmad,
Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia,
Revista de Chimie,
Volume 71, Issue 10,
2020,
Pages 182-192,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.10.8362.
(https://revistadechimie.ro/Articles.asp?ID=8362)
Keywords: Proton Pump Inhibitors; DRD2 receptor; Docking; MD Simulation; Hyperprolactinemia

RIS
TY - JOUR
T1 - Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia
A1 - Ashfaq, Muhammad
A2 - Abid, S. Mobasher Ali
A3 - Rauf, Khalid
A4 - Alkahraman, Yasser Msa
A5 - Haroon, Muhammad Zeeshan
A6 - Ahmad, Fawad
A7 - Ikram, Saima
A8 - Ahmad, Jamshaid
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 10
SP - 182
EP - 192
UR - https://doi.org/10.37358/RC.20.10.8362
KW - Proton Pump Inhibitors
KW - DRD2 receptor
KW - Docking
KW - MD Simulation
KW - Hyperprolactinemia
ER -

BibTex
@article{RevCh2020P182,
author = {Ashfaq Muhammad and Abid S. Mobasher Ali and Rauf Khalid and Alkahraman Yasser Msa and Haroon Muhammad Zeeshan and Ahmad Fawad and Ikram Saima and Ahmad Jamshaid},
title = {Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia},
journal = {Revista de Chimie},
volume = {71},
number = {10},
pages = {182-192},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.10.8362},
url = {https://revistadechimie.ro/Articles.asp?ID=8362}
}

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