Genetic and Biochemical Markers of Ovarian Function and Their Impact on Women Reproductive Status

Tanase, Adina-Elena; Popescu, Roxana; Onofriescu, Mircea; Matasariu, Roxana Daniela

Adina-Elena Tanase, Roxana Popescu, Mircea Onofriescu, Roxana Daniela Matasariu

Genetic and Biochemical Markers of Ovarian Function and Their Impact on Women Reproductive Status

Abstract:

Endometriosis is a disease very common nowadays affecting 1-2% of the female population, by estrogen-dependent mechanism. The identification of mutations in the gene encoding for the FSH receptor (FSHR) has been reported since 1995. Physiology teaches us that follicle-stimulating hormone (FSH) is a hormone that is vital in the steroidogenesis regulation mechanisms, while FSH receptor (FSHR) activation helps to promote folliculogenesis and estrogensynthesis. Therefore, studies to show if there are any correlations between endometriosis and FSHR are acquired. Genotyping of FSHR gene polymorphisms were performed using PCR - Restriction Fragment Length Polymorphism (PCR-RFLP) analysis. We analysed a total of 78 patients, 44 infertile patients with endometriosis and 34 controls (non-infertile, pregnant patients). The endometriosis group included women with diagnosis of endo-metriosis confirmed by laparoscopy and /or laparotomy and histological evidence of disease with the endometriosis staging according to American Society for Reproductive Medicine (ASRM). Corroborated with the severity of endometriosis, A919G and A2039G tests found that 71.4% of the M (GG) results were associated with primary infertility, not statistically significant (p=0.994) and 42.9% of the total M results had moderate or severe forms of endometriosis (p = 0.185). The genetic involvement in different pathologies such as endometriosis, has yet to be understood, but knowing more about its mechanism, will help physician target the disease at a more profound level.

Keywords:
endometriosis; infertility; reproductive medicine; FSHR gene polymorphism

Issue: 2020, Volume 71, Issue 10

Pages: 212-217

Publication date: 2020/11/3

https://doi.org/10.37358/RC.20.10.8365

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TANASE, A., POPESCU, R., ONOFRIESCU, M., MATASARIU, R.D., Genetic and Biochemical Markers of Ovarian Function and Their Impact on Women Reproductive Status, Rev. Chim., 71(10), 2020, 212-217.

Vancouver
Tanase A, Popescu R, Onofriescu M, Matasariu RD. Genetic and Biochemical Markers of Ovarian Function and Their Impact on Women Reproductive Status. Rev. Chim.[internet]. 2020 Oct;71(10):212-217. Available from: https://doi.org/10.37358/RC.20.10.8365

APA 6th edition
Tanase, A., Popescu, R., Onofriescu, M. & Matasariu, R.D. (2020). Genetic and Biochemical Markers of Ovarian Function and Their Impact on Women Reproductive Status. Revista de Chimie, 71(10), 212-217. https://doi.org/10.37358/RC.20.10.8365

Harvard
Tanase, A., Popescu, R., Onofriescu, M., Matasariu, R.D. (2020). 'Genetic and Biochemical Markers of Ovarian Function and Their Impact on Women Reproductive Status', Revista de Chimie, 71(10), pp. 212-217. https://doi.org/10.37358/RC.20.10.8365

IEEE
A. Tanase, R. Popescu, M. Onofriescu, R.D. Matasariu, "Genetic and Biochemical Markers of Ovarian Function and Their Impact on Women Reproductive Status". Revista de Chimie, vol. 71, no. 10, pp. 212-217, 2020. [online]. https://doi.org/10.37358/RC.20.10.8365

Text
Adina-Elena Tanase, Roxana Popescu, Mircea Onofriescu, Roxana Daniela Matasariu,
Genetic and Biochemical Markers of Ovarian Function and Their Impact on Women Reproductive Status,
Revista de Chimie,
Volume 71, Issue 10,
2020,
Pages 212-217,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.10.8365.
(https://revistadechimie.ro/Articles.asp?ID=8365)
Keywords: endometriosis; infertility; reproductive medicine; FSHR gene polymorphism

RIS
TY - JOUR
T1 - Genetic and Biochemical Markers of Ovarian Function and Their Impact on Women Reproductive Status
A1 - Tanase, Adina-Elena
A2 - Popescu, Roxana
A3 - Onofriescu, Mircea
A4 - Matasariu, Roxana Daniela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 10
SP - 212
EP - 217
UR - https://doi.org/10.37358/RC.20.10.8365
KW - endometriosis
KW - infertility
KW - reproductive medicine
KW - FSHR gene polymorphism
ER -

BibTex
@article{RevCh2020P212,
author = {Tanase Adina-Elena and Popescu Roxana and Onofriescu Mircea and Matasariu Roxana Daniela},
title = {Genetic and Biochemical Markers of Ovarian Function and Their Impact on Women Reproductive Status},
journal = {Revista de Chimie},
volume = {71},
number = {10},
pages = {212-217},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.10.8365},
url = {https://revistadechimie.ro/Articles.asp?ID=8365}
}

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