ABOUT INDEXING BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER AUTHOR'S PAGE NEWS, EVENTS CONTACT
REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

REVISTA DE CHIMIE Latest Issue

LATEST ISSUE >>>

   Volume 76, 2025
   Volume 75, 2024
   Volume 74, 2023
   Volume 73, 2022
   Volume 72, 2021
   Volume 71, 2020
   Volume 70, 2019
   Volume 69, 2018
   Volume 68, 2017
   Volume 67, 2016
   Volume 66, 2015
   Volume 65, 2014
   Volume 64, 2013
   Volume 63, 2012
   Volume 62, 2011
   Volume 61, 2010
   Volume 60, 2009
   Volume 59, 2008
   Volume 58, 2007
 
<<<< back

Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 11, 80-86

https://doi.org/10.37358/RC.20.11.8376

Muhamad Firdaus, Rahmi Nurdiani, Indri Novita Artasasta, Sayyidah Mutoharoh, Oni Pratiwi

Potency of Three Brown Seaweeds Species as the Inhibitor of RNA-dependent RNA Polymerase of SARS-CoV-2

Abstract:

The objective of this study was to evaluate the binding activity of bioactive compounds from three brown seaweed on RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 by docking method. The bioactive identification of Sargassum cristaefolium, S. echinocarpum, and Padina australis was carried out using HPLC-HRMS. The ligand structures in PDB format were obtained from the PubChem website and the RdRp from the RCSB website. The binding affinity of the interaction of bioactive components with the RdRp Covid-19 was determined by docking method using AutoDock Vina on PyRx software. The visualization of 2D and 3D interactions between ligands and macromolecules were carried out with the Biovia Discovery Studio and PyMol software. The decoction of S. cristaefolium, S. echinocarpum, and P. australis contained ninety one compounds, and there were twenty compounds with a strong affinity for RdRp. Rhamnetin was a compound of the Sargassum species have the strongest binding affinity of -7.6 kcal/mol. Its affinity bonds were hydrogen bonds in Val315, Arg349, Phe396, Asn628, and hydrophobic bonds in the form of bonds to - and -alkyl from Pro461. Taribavirin bound to RdRp in hydrogen bonds at Thr393, Thr394, and Phe396 and bound hydrophobically to -alkyl from Cys395. Rhamnetin has the same binding affinity region as taribavirin, which was the subdomain finger of the RdRp. In conclusion, rhamnetin is a compound of Sargassum sp that can inhibit the replication and transcription of RdRp SARS-CoV-2 and further studies using the molecular dynamics method on the mechanism of interaction between rhamnetin and the viral RdRp of SARS-CoV-2 are mandatory.
Keywords:
Brown algae; Decoction; HPLC HRMS; in silico; RdRp

Issue: 2020, Volume 71, Issue 11
Pages: 80-86
Publication date: 2020/12/4
https://doi.org/10.37358/RC.20.11.8376
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
FIRDAUS, M., NURDIANI, R., ARTASASTA, I.N., MUTOHAROH, S., PRATIWI, O., Potency of Three Brown Seaweeds Species as the Inhibitor of RNA-dependent RNA Polymerase of SARS-CoV-2, Rev. Chim., 71(11), 2020, 80-86.

Vancouver
Firdaus M, Nurdiani R, Artasasta IN, Mutoharoh S, Pratiwi O. Potency of Three Brown Seaweeds Species as the Inhibitor of RNA-dependent RNA Polymerase of SARS-CoV-2. Rev. Chim.[internet]. 2020 Nov;71(11):80-86. Available from: https://doi.org/10.37358/RC.20.11.8376


APA 6th edition
Firdaus, M., Nurdiani, R., Artasasta, I.N., Mutoharoh, S. & Pratiwi, O. (2020). Potency of Three Brown Seaweeds Species as the Inhibitor of RNA-dependent RNA Polymerase of SARS-CoV-2. Revista de Chimie, 71(11), 80-86. https://doi.org/10.37358/RC.20.11.8376


Harvard
Firdaus, M., Nurdiani, R., Artasasta, I.N., Mutoharoh, S., Pratiwi, O. (2020). 'Potency of Three Brown Seaweeds Species as the Inhibitor of RNA-dependent RNA Polymerase of SARS-CoV-2', Revista de Chimie, 71(11), pp. 80-86. https://doi.org/10.37358/RC.20.11.8376


IEEE
M. Firdaus, R. Nurdiani, I.N. Artasasta, S. Mutoharoh, O. Pratiwi, "Potency of Three Brown Seaweeds Species as the Inhibitor of RNA-dependent RNA Polymerase of SARS-CoV-2". Revista de Chimie, vol. 71, no. 11, pp. 80-86, 2020. [online]. https://doi.org/10.37358/RC.20.11.8376


Text
Muhamad Firdaus, Rahmi Nurdiani, Indri Novita Artasasta, Sayyidah Mutoharoh, Oni Pratiwi,
Potency of Three Brown Seaweeds Species as the Inhibitor of RNA-dependent RNA Polymerase of SARS-CoV-2,
Revista de Chimie,
Volume 71, Issue 11,
2020,
Pages 80-86,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.11.8376.
(https://revistadechimie.ro/Articles.asp?ID=8376)
Keywords: Brown algae; Decoction; HPLC HRMS; in silico; RdRp


RIS
TY - JOUR
T1 - Potency of Three Brown Seaweeds Species as the Inhibitor of RNA-dependent RNA Polymerase of SARS-CoV-2
A1 - Firdaus, Muhamad
A2 - Nurdiani, Rahmi
A3 - Artasasta, Indri Novita
A4 - Mutoharoh, Sayyidah
A5 - Pratiwi, Oni
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 11
SP - 80
EP - 86
UR - https://doi.org/10.37358/RC.20.11.8376
KW - Brown algae
KW - Decoction
KW - HPLC HRMS
KW - in silico
KW - RdRp
ER -


BibTex
@article{RevCh2020P80,
author = {Firdaus Muhamad and Nurdiani Rahmi and Artasasta Indri Novita and Mutoharoh Sayyidah and Pratiwi Oni},
title = {Potency of Three Brown Seaweeds Species as the Inhibitor of RNA-dependent RNA Polymerase of SARS-CoV-2},
journal = {Revista de Chimie},
volume = {71},
number = {11},
pages = {80-86},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.11.8376},
url = {https://revistadechimie.ro/Articles.asp?ID=8376}
}
 
<<<< back
 
PUBLISHING SECTION
Author Guidelines
 * Paper Drafting
 * Paper Template
 * Ethical Statement
 * Paper Submission
Ghidul Autorului (ro)
Submit Paper
Author's Page
Publishing Ethics
Peer Review Process
Open Access & Archiving Policy
 Search Authors
 LATEST NEWS
REvista de Chimie NUMAR OMAGIAL PETRU PONI.. detalii
REvista de Chimie Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
dictionar English-Romanian Dictionary for Mechanical Engineering
(download pdf)
  News, Events
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License
 Conferences of Contemporary
 Chemistry
 Biblioteca Chimiei
 Materiale Plastice