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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 12, 156-163

https://doi.org/10.37358/RC.20.12.8396

Alexandra Gabriela Catianis, Bogdana Virgolici, Carmen Beatrice Dogaru, Laura Anca Popescu, Daniel Miricescu, Alexandra Totan, Horia Marius Virgolici, Maria Mohora

The Serum Selenium Level, the Activity of Some Selenodependent Enzymes and the Lipid Profile in Childhood Obesity

Abstract:

Oxidative stress and dyslipidemia are present in childhood obesity. Selenoproteins are important antioxidants. Glutathione peroxidase and thioredoxin reduce the level of peroxides while the conversion of the tyroid hormon T4 to T3 needs also a selenoenzyme. Selenium deficiency can reduce the selenoproteins activity. The aim of this study was to determine the serum: selenium (Se), thioredoxin level (Trx) and activity of glutathione peroxidase (GPx) in obese children with dysmetabolism. The lipid profile, the hormones (free T4 and TSH), serum Se, serum Trx and GPx activity and atherogenic indexes (TG/HDLc, total cholesterol/HDLc, apoB/apoA-I ) were determined in 20 healthy children (10-16 years old) versus 41 overweight/obese children, same age, in an observational study. Spectro-photometer and ELISA methods were used. The GPx activity and the serum Se level had similar values in the studied groups , while the serum Trx level was lower in the obese children. The GPx activity was positively correlated with atherogenic indexes, negatively correlated with apo A-I (r= -0.74) and Se was positively correlated with apo B (r=0.52). The obese children had TSH and freeT4 in the normal range, but freeT4 was significantly higher in comparison with the values observed in the normal weight children. In conclusion, in childhood obesity, the normal serum range values for selenium or for selenium dependent proteins can “hide”a dysmetabolism of selenium because there are significant differences for the values of these parameters versus the ones from normal weight children. In childhood obesity, serum GPx activity and selenium values were strongly correlated with the atherogenic indexes.
Keywords:
childhood obesity; selenium; oxidative stress; atherogenesis

Issue: 2020, Volume 71, Issue 12
Pages: 156-163
Publication date: 2021/1/7
https://doi.org/10.37358/RC.20.12.8396
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
CATIANIS, A.G., VIRGOLICI, B., DOGARU, C.B., POPESCU, L.A., MIRICESCU, D., TOTAN, A., VIRGOLICI, H.M., MOHORA, M., The Serum Selenium Level, the Activity of Some Selenodependent Enzymes and the Lipid Profile in Childhood Obesity, Rev. Chim., 71(12), 2020, 156-163.

Vancouver
Catianis AG, Virgolici B, Dogaru CB, Popescu LA, Miricescu D, Totan A, Virgolici HM, Mohora M. The Serum Selenium Level, the Activity of Some Selenodependent Enzymes and the Lipid Profile in Childhood Obesity. Rev. Chim.[internet]. 2020 Dec;71(12):156-163. Available from: https://doi.org/10.37358/RC.20.12.8396


APA 6th edition
Catianis, A.G., Virgolici, B., Dogaru, C.B., Popescu, L.A., Miricescu, D., Totan, A., Virgolici, H.M. & Mohora, M. (2020). The Serum Selenium Level, the Activity of Some Selenodependent Enzymes and the Lipid Profile in Childhood Obesity. Revista de Chimie, 71(12), 156-163. https://doi.org/10.37358/RC.20.12.8396


Harvard
Catianis, A.G., Virgolici, B., Dogaru, C.B., Popescu, L.A., Miricescu, D., Totan, A., Virgolici, H.M., Mohora, M. (2020). 'The Serum Selenium Level, the Activity of Some Selenodependent Enzymes and the Lipid Profile in Childhood Obesity', Revista de Chimie, 71(12), pp. 156-163. https://doi.org/10.37358/RC.20.12.8396


IEEE
A.G. Catianis, B. Virgolici, C.B. Dogaru, L.A. Popescu, D. Miricescu, A. Totan, H.M. Virgolici, M. Mohora, "The Serum Selenium Level, the Activity of Some Selenodependent Enzymes and the Lipid Profile in Childhood Obesity". Revista de Chimie, vol. 71, no. 12, pp. 156-163, 2020. [online]. https://doi.org/10.37358/RC.20.12.8396


Text
Alexandra Gabriela Catianis, Bogdana Virgolici, Carmen Beatrice Dogaru, Laura Anca Popescu, Daniel Miricescu, Alexandra Totan, Horia Marius Virgolici, Maria Mohora,
The Serum Selenium Level, the Activity of Some Selenodependent Enzymes and the Lipid Profile in Childhood Obesity,
Revista de Chimie,
Volume 71, Issue 12,
2020,
Pages 156-163,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.12.8396.
(https://revistadechimie.ro/Articles.asp?ID=8396)
Keywords: childhood obesity; selenium; oxidative stress; atherogenesis


RIS
TY - JOUR
T1 - The Serum Selenium Level, the Activity of Some Selenodependent Enzymes and the Lipid Profile in Childhood Obesity
A1 - Catianis, Alexandra Gabriela
A2 - Virgolici, Bogdana
A3 - Dogaru, Carmen Beatrice
A4 - Popescu, Laura Anca
A5 - Miricescu, Daniel
A6 - Totan, Alexandra
A7 - Virgolici, Horia Marius
A8 - Mohora, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 12
SP - 156
EP - 163
UR - https://doi.org/10.37358/RC.20.12.8396
KW - childhood obesity
KW - selenium
KW - oxidative stress
KW - atherogenesis
ER -


BibTex
@article{RevCh2020P156,
author = {Catianis Alexandra Gabriela and Virgolici Bogdana and Dogaru Carmen Beatrice and Popescu Laura Anca and Miricescu Daniel and Totan Alexandra and Virgolici Horia Marius and Mohora Maria},
title = {The Serum Selenium Level, the Activity of Some Selenodependent Enzymes and the Lipid Profile in Childhood Obesity},
journal = {Revista de Chimie},
volume = {71},
number = {12},
pages = {156-163},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.12.8396},
url = {https://revistadechimie.ro/Articles.asp?ID=8396}
}
 
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