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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Print 0034-7752
ISSN Online 2668-8212
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Revista de Chimie (Rev. Chim.), Year 2021, Volume 72, Issue 1, 90-99

https://doi.org/10.37358/RC.21.1.8406

Narcis Anghel, Maria Valentina Dinu, Florica Doroftei, Iuliana Spiridon

Xanthan Matrix as Drug ZDelivery System

Abstract:

Here we present a new drug delivery system based on xanthan esterified with acrylic acid. This material served as a matrix for the incorporation of bioactive substances with antimicrobial and anti-inflammatory properties. The materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) and Scanning Electron Micrography (SEM). Mechanical strength tests showed a substantial improvement in the resilience and flexibility of the polymer matrix modified by esterification under conditions of mechanical stress. The release of bioactive substances from the basic matrix follows a Korsmeyer-Peppas type kinetics. The modified xanthan-based transport system was shown to be antimicrobially active with an inhibition rate of almost 100% on gram-positive and gram-negative bacteria. The obtained results recommend this biomaterial for the manufacture of transdermal drug delivery devices.
Keywords:
xanthan; acrylic acid; amoxicilin; ketoprofen; drug delivery

Issue: 2021, Volume 72, Issue 1
Pages: 90-99
Publication date: 2021/2/3
https://doi.org/10.37358/RC.21.1.8406
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
ANGHEL, N., DINU, M.V., DOROFTEI, F., SPIRIDON, I., Xanthan Matrix as Drug ZDelivery System, Rev. Chim., 72(1), 2021, 90-99.

Vancouver
Anghel N, Dinu MV, Doroftei F, Spiridon I. Xanthan Matrix as Drug ZDelivery System. Rev. Chim.[internet]. 2021 Jan;72(1):90-99. Available from: https://doi.org/10.37358/RC.21.1.8406


APA 6th edition
Anghel, N., Dinu, M.V., Doroftei, F. & Spiridon, I. (2021). Xanthan Matrix as Drug ZDelivery System. Revista de Chimie, 72(1), 90-99. https://doi.org/10.37358/RC.21.1.8406


Harvard
Anghel, N., Dinu, M.V., Doroftei, F., Spiridon, I. (2021). 'Xanthan Matrix as Drug ZDelivery System', Revista de Chimie, 72(1), pp. 90-99. https://doi.org/10.37358/RC.21.1.8406


IEEE
N. Anghel, M.V. Dinu, F. Doroftei, I. Spiridon, "Xanthan Matrix as Drug ZDelivery System". Revista de Chimie, vol. 72, no. 1, pp. 90-99, 2021. [online]. https://doi.org/10.37358/RC.21.1.8406


Text
Narcis Anghel, Maria Valentina Dinu, Florica Doroftei, Iuliana Spiridon,
Xanthan Matrix as Drug ZDelivery System,
Revista de Chimie,
Volume 72, Issue 1,
2021,
Pages 90-99,
ISSN 2668-8212,
https://doi.org/10.37358/RC.21.1.8406.
(https://revistadechimie.ro/Articles.asp?ID=8406)
Keywords: xanthan; acrylic acid; amoxicilin; ketoprofen; drug delivery


RIS
TY - JOUR
T1 - Xanthan Matrix as Drug ZDelivery System
A1 - Anghel, Narcis
A2 - Dinu, Maria Valentina
A3 - Doroftei, Florica
A4 - Spiridon, Iuliana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2021
VL - 72
IS - 1
SP - 90
EP - 99
UR - https://doi.org/10.37358/RC.21.1.8406
KW - xanthan
KW - acrylic acid
KW - amoxicilin
KW - ketoprofen
KW - drug delivery
ER -


BibTex
@article{RevCh2021P90,
author = {Anghel Narcis and Dinu Maria Valentina and Doroftei Florica and Spiridon Iuliana},
title = {Xanthan Matrix as Drug ZDelivery System},
journal = {Revista de Chimie},
volume = {72},
number = {1},
pages = {90-99},
year = {2021},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.21.1.8406},
url = {https://revistadechimie.ro/Articles.asp?ID=8406}
}
 
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