Phytochemical Profiling of Medicinal Plants Extracts and Their Antioxidant and Anticancer Potentialities Against Human Liver Cancer (Hep G2) Cell Lines

Shafiq, Nusrat; Yasmin, Farah; Noreen, Sadia; Shahzad, Alina; Nazli, Zill-I-huma; Parveen, Shagufta; Ali, Basharat; Ahmad, Zaheer; Rashid, Maryam; Bilal, Muhammad

Nusrat Shafiq, Farah Yasmin, Sadia Noreen, Alina Shahzad, Zill-I-huma Nazli, Shagufta Parveen, Basharat Ali, Zaheer Ahmad, Maryam Rashid, Muhammad Bilal

Phytochemical Profiling of Medicinal Plants Extracts and Their Antioxidant and Anticancer Potentialities Against Human Liver Cancer (Hep G2) Cell Lines

Abstract:

Although Pakistan is stacked with enormous varieties of medicinal plants, only a little proportion of these plants has been evaluated for their medicinal and therapeutic properties. Herein, four indigenous medicinal plants Citrus sinenesis, Citrus paradiasii, Moringa olifera, and Hibiscus rosa-sinenesis were collected and subjected to phytochemical analyses to scrutinize the presence of secondary metabolites. Qualitative analy¬sis showed the presence of an array of secondary metabolites in the selected plants, which were further corroborated by high-performance liquid chromatography. Results revealed the presence of 33.24, 21.04, 15.2 ppm gallic acid in methanol, ethyl acetate and n-hexane fraction of C. sinensis peels extract, respectively. C. paradaissi peels consist of 24.06, and 18.24 ppm of gallic acid and caffeic acid, respectively, in methanol and chloroform fractions, whereas its methanolic seeds extract contain caffeic acid as a major component (10.63 ppm). H. rosa-sinenesis has shown p-coumaric acid, caffeic acid, and gallic acid at 35.26, 15.04, and 11.4 ppm, respectively. M. olifera contained 3.24 ppm gallic acid in pods extract while stems and leaves extract contain a very low amount. Anticancer profile evinced that Citrus sinensis extract showed the highest percent inhibition (142.746%) of human liver cancer (Hep G2) cell lines followed by H. rosa-sinensis (132.49%), C. paradaisii (82.39%) and M. olifera (68.0%). The determined IC50 values for antioxidant activity were C. sinenesis (IC50=0.49 mM), C. paradaisii (IC50=0.43 mM), M. olifera (IC50=0.42 mM) and H. rosa-sinensis (IC50=0.41 mM). Conclusively, the selected plants could be an effective alternative and deliverable chemical therapeutic to the pharmaceutical industry due to their excellent biological effects.

Keywords:
Medicinal plants; Phytoconstituents; Flavonoids; Antioxidant activity; Anticancer; Cytotoxicity

Issue: 2021, Volume 72, Issue 1

Pages: 100-110

Publication date: 2021/2/3

https://doi.org/10.37358/RC.21.1.8407

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SHAFIQ, N., YASMIN, F., NOREEN, S., SHAHZAD, A., NAZLI, Z., PARVEEN, S., ALI, B., AHMAD, Z., RASHID, M., BILAL, M., Phytochemical Profiling of Medicinal Plants Extracts and Their Antioxidant and Anticancer Potentialities Against Human Liver Cancer (Hep G2) Cell Lines, Rev. Chim., 72(1), 2021, 100-110.

Vancouver
Shafiq N, Yasmin F, Noreen S, Shahzad A, Nazli Z, Parveen S, Ali B, Ahmad Z, Rashid M, Bilal M. Phytochemical Profiling of Medicinal Plants Extracts and Their Antioxidant and Anticancer Potentialities Against Human Liver Cancer (Hep G2) Cell Lines. Rev. Chim.[internet]. 2021 Jan;72(1):100-110. Available from: https://doi.org/10.37358/RC.21.1.8407

APA 6th edition
Shafiq, N., Yasmin, F., Noreen, S., Shahzad, A., Nazli, Z., Parveen, S.,... Bilal, M. (2021). Phytochemical Profiling of Medicinal Plants Extracts and Their Antioxidant and Anticancer Potentialities Against Human Liver Cancer (Hep G2) Cell Lines. Revista de Chimie, 72(1), 100-110. https://doi.org/10.37358/RC.21.1.8407

Harvard
Shafiq, N., Yasmin, F., Noreen, S., Shahzad, A., Nazli, Z., Parveen, S., Ali, B., Ahmad, Z., Rashid, M., Bilal, M. (2021). 'Phytochemical Profiling of Medicinal Plants Extracts and Their Antioxidant and Anticancer Potentialities Against Human Liver Cancer (Hep G2) Cell Lines', Revista de Chimie, 72(1), pp. 100-110. https://doi.org/10.37358/RC.21.1.8407

IEEE
N. Shafiq, F. Yasmin, S. Noreen, A. Shahzad, Z. Nazli, S. Parveen, B. Ali, Z. Ahmad, M. Rashid, M. Bilal, "Phytochemical Profiling of Medicinal Plants Extracts and Their Antioxidant and Anticancer Potentialities Against Human Liver Cancer (Hep G2) Cell Lines". Revista de Chimie, vol. 72, no. 1, pp. 100-110, 2021. [online]. https://doi.org/10.37358/RC.21.1.8407

Text
Nusrat Shafiq, Farah Yasmin, Sadia Noreen, Alina Shahzad, Zill-I-huma Nazli, Shagufta Parveen, Basharat Ali, Zaheer Ahmad, Maryam Rashid, Muhammad Bilal,
Phytochemical Profiling of Medicinal Plants Extracts and Their Antioxidant and Anticancer Potentialities Against Human Liver Cancer (Hep G2) Cell Lines,
Revista de Chimie,
Volume 72, Issue 1,
2021,
Pages 100-110,
ISSN 2668-8212,
https://doi.org/10.37358/RC.21.1.8407.
(https://revistadechimie.ro/Articles.asp?ID=8407)
Keywords: Medicinal plants; Phytoconstituents; Flavonoids; Antioxidant activity; Anticancer; Cytotoxicity

RIS
TY - JOUR
T1 - Phytochemical Profiling of Medicinal Plants Extracts and Their Antioxidant and Anticancer Potentialities Against Human Liver Cancer (Hep G2) Cell Lines
A1 - Shafiq, Nusrat
A2 - Yasmin, Farah
A3 - Noreen, Sadia
A4 - Shahzad, Alina
A5 - Nazli, Zill-I-huma
A6 - Parveen, Shagufta
A7 - Ali, Basharat
A8 - Ahmad, Zaheer
A9 - Rashid, Maryam
A10 - Bilal, Muhammad
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2021
VL - 72
IS - 1
SP - 100
EP - 110
UR - https://doi.org/10.37358/RC.21.1.8407
KW - Medicinal plants; Phytoconstituents; Flavonoids; Antioxidant activity; Anticancer; Cytotoxicity
ER -

BibTex
@article{RevCh2021P100,
author = {Shafiq Nusrat and Yasmin Farah and Noreen Sadia and Shahzad Alina and Nazli Zill-I-huma and Parveen Shagufta and Ali Basharat and Ahmad Zaheer and Rashid Maryam and Bilal Muhammad},
title = {Phytochemical Profiling of Medicinal Plants Extracts and Their Antioxidant and Anticancer Potentialities Against Human Liver Cancer (Hep G2) Cell Lines},
journal = {Revista de Chimie},
volume = {72},
number = {1},
pages = {100-110},
year = {2021},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.21.1.8407},
url = {https://revistadechimie.ro/Articles.asp?ID=8407}
}

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