Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats

Aljerf, Loai; Williams, Mike; Ajong, Atem Bethel; Onydinma, Ukaogo Prince; Dehmchi, Farouk; Pham, Viet Ty; Bhatnagar, Suhasini; Belboukhari, Nasser

Loai Aljerf, Mike Williams, Atem Bethel Ajong, Ukaogo Prince Onydinma, Farouk Dehmchi, Viet Ty Pham, Suhasini Bhatnagar, Nasser Belboukhari

Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats

Abstract:

Many researchers have studied the metabolism of toxics including selenium (Se) in biological medium in rats and defined some correlations between selenium and other minerals as arsenic (As), cadmium (Cd), mercury (Hg), and thallium (Tl). An investigation of the potential influences of As, Hg, Tl and Pb on Se metabolism, which can suggest new drugs to cope the poisonousness of Se. The current study also has looked into the potential use of As(III)/As(V) toxic in the treatment of essential mineral Se in the animals (as rats) based on sequestration of these toxic elements into biologically inert complexes, reflecting the enormous interest in this subject. The acute studies have been initially achieved by shaping the pulmonary and biliary excretions of the volatile Se in neonatal masculine Holtzman rats which were injected with selenite subcutaneously in the hind flank, then the volatile Se was trapped in 8N HNO3 and the radioselenate detected in a scintillation counter. The chronic cases were carried out with the nursing of rats with a purified diet of water-soluble vitamin mix, fat-soluble vitamin mix, saccharides, oil, and salts. One week after the basic diet, the rats taken Se have received diets containing 10 ppm of the element as sodium selenite (Na2SeO3) or selenate (Na2SeO4) added in the salts. The calorimeter was used to analyze Se in the frozen tissue specimens. As, Hg, and Tl were repressed the volatized Se excreted from the lungs. As has assisted the biliary excretion of Se and inhibited the chronic selenosis. Tl has increased the retention of Se in the liver and kidney, but, had no chronic effect on the amount of Se deposited in all the studied tissues. Similarly, Hg has increased the retention of Se but in the spleen and carcass of rats indicating to the high Se concentration in blood. Hg and Tl have inhibited the Se in urine. No effects of the doses rich in As, Hg, and Tl on the Se excretion in fecal. Even though, we suggest As as a possible medication to chronic selenosis.

Keywords:
Biological medium; New drug; Poisonousness of Se; Biliary excretion; Tissue; Carcass; Cancer cell

Issue: 2021, Volume 72, Issue 2

Pages: 9-18

Publication date: 2021/5/7

https://doi.org/10.37358/RC.21.2.8415

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ALJERF, L., WILLIAMS, M., AJONG, A.B., ONYDINMA, U.P., DEHMCHI, F., PHAM, V.T., BHATNAGAR, S., BELBOUKHARI, N., Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats, Rev. Chim., 72(2), 2021, 9-18.

Vancouver
Aljerf L, Williams M, Ajong AB, Onydinma UP, Dehmchi F, Pham VT, Bhatnagar S, Belboukhari N. Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats. Rev. Chim.[internet]. 2021 Feb;72(2):9-18. Available from: https://doi.org/10.37358/RC.21.2.8415

APA 6th edition
Aljerf, L., Williams, M., Ajong, A.B., Onydinma, U.P., Dehmchi, F., Pham, V.T., Bhatnagar, S. & Belboukhari, N. (2021). Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats. Revista de Chimie, 72(2), 9-18. https://doi.org/10.37358/RC.21.2.8415

Harvard
Aljerf, L., Williams, M., Ajong, A.B., Onydinma, U.P., Dehmchi, F., Pham, V.T., Bhatnagar, S., Belboukhari, N. (2021). 'Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats', Revista de Chimie, 72(2), pp. 9-18. https://doi.org/10.37358/RC.21.2.8415

IEEE
L. Aljerf, M. Williams, A.B. Ajong, U.P. Onydinma, F. Dehmchi, V.T. Pham, S. Bhatnagar, N. Belboukhari, "Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats". Revista de Chimie, vol. 72, no. 2, pp. 9-18, 2021. [online]. https://doi.org/10.37358/RC.21.2.8415

Text
Loai Aljerf, Mike Williams, Atem Bethel Ajong, Ukaogo Prince Onydinma, Farouk Dehmchi, Viet Ty Pham, Suhasini Bhatnagar, Nasser Belboukhari,
Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats,
Revista de Chimie,
Volume 72, Issue 2,
2021,
Pages 9-18,
ISSN 2668-8212,
https://doi.org/10.37358/RC.21.2.8415.
(https://revistadechimie.ro/Articles.asp?ID=8415)
Keywords: Biological medium; New drug; Poisonousness of Se; Biliary excretion; Tissue; Carcass; Cancer cell

RIS
TY - JOUR
T1 - Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats
A1 - Aljerf, Loai
A2 - Williams, Mike
A3 - Ajong, Atem Bethel
A4 - Onydinma, Ukaogo Prince
A5 - Dehmchi, Farouk
A6 - Pham, Viet Ty
A7 - Bhatnagar, Suhasini
A8 - Belboukhari, Nasser
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2021
VL - 72
IS - 2
SP - 9
EP - 18
UR - https://doi.org/10.37358/RC.21.2.8415
KW - Biological medium
KW - New drug
KW - Poisonousness of Se
KW - Biliary excretion
KW - Tissue
KW - Carcass
KW - Cancer cell
ER -

BibTex
@article{RevCh2021P9,
author = {Aljerf Loai and Williams Mike and Ajong Atem Bethel and Onydinma Ukaogo Prince and Dehmchi Farouk and Pham Viet Ty and Bhatnagar Suhasini and Belboukhari Nasser},
title = {Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats},
journal = {Revista de Chimie},
volume = {72},
number = {2},
pages = {9-18},
year = {2021},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.21.2.8415},
url = {https://revistadechimie.ro/Articles.asp?ID=8415}
}

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