Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice

Alhazani, Tahani Mohamad; Aldahmash, Badr Abdullah; El-Nagar, Doaa Mohamed; Ibrahim, Khalid Elfaki; Anifowose, Saheed Olaide; Rady, Ahmed Mostafa

Tahani Mohamad Alhazani, Badr Abdullah Aldahmash, Doaa Mohamed El-Nagar, Khalid Elfaki Ibrahim, Saheed Olaide Anifowose, Ahmed Mostafa Rady

Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice

Abstract:

The beet root as dietary supplement hepatoprotective ability has gained interest in recent days. The present study was designed to determine the potential hepatoprotective effect of beet root juice as anti-inflammatory and anti-oxidant agent to eliminate the hepatotoxic effect of diclofenac as wide spread analgesic agent. Male albino mice were divided randomly into 4 groups, the 1st group served as control group, the 2nd group received 8 mL/kg of freshly prepared beet root juice, the 3rd group received oral administration 20 mg/kg of diclofenac and the 4th group pre-treated with beet root before one-hour diclofenac administration for 30 days. Biochemical results revealed sharp significant raised levels of liver enzymes level (AST, ALT, ALP and GGT) in the 3rd group that received diclofenac, besides to marked pathological changes manifested by high pathological scoring system such as hepatocytes degeneration, ballooning, infiltration and fibrosis. Immunohistochemical analysis elucidated massive incidence of MDA as an indicator of oxidative stress, moreover great number of neutrophils were seen as main component of inflammation. Whereas, pre-treatment of beet root juice one hour before diclofenac resulted in significant decrease of liver enzymes, clear attenuation of pathological features, decrease of pathological score. A great reduction of MDA in liver tissue and number of neutrophils stained histochemically. It was concluded that beet root juice possessed beneficial hepatoprotective role against diclofenac, as significant anti-oxidant and anti-inflammatory effect.

Keywords:
Hepatotoxicity; diclofenac; beet root; inflammation; oxidative stress

Issue: 2021, Volume 72, Issue 2

Pages: 19-26

Publication date: 2021/5/7

https://doi.org/10.37358/RC.21.2.8416

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ALHAZANI, T.M., ALDAHMASH, B.A., EL-NAGAR, D.M., IBRAHIM, K.E., ANIFOWOSE, S.O., RADY, A.M., Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice, Rev. Chim., 72(2), 2021, 19-26.

Vancouver
Alhazani TM, Aldahmash BA, El-Nagar DM, Ibrahim KE, Anifowose SO, Rady AM. Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice. Rev. Chim.[internet]. 2021 Feb;72(2):19-26. Available from: https://doi.org/10.37358/RC.21.2.8416

APA 6th edition
Alhazani, T.M., Aldahmash, B.A., El-Nagar, D.M., Ibrahim, K.E., Anifowose, S.O. & Rady, A.M. (2021). Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice. Revista de Chimie, 72(2), 19-26. https://doi.org/10.37358/RC.21.2.8416

Harvard
Alhazani, T.M., Aldahmash, B.A., El-Nagar, D.M., Ibrahim, K.E., Anifowose, S.O., Rady, A.M. (2021). 'Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice', Revista de Chimie, 72(2), pp. 19-26. https://doi.org/10.37358/RC.21.2.8416

IEEE
T.M. Alhazani, B.A. Aldahmash, D.M. El-Nagar, K.E. Ibrahim, S.O. Anifowose, A.M. Rady, "Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice". Revista de Chimie, vol. 72, no. 2, pp. 19-26, 2021. [online]. https://doi.org/10.37358/RC.21.2.8416

Text
Tahani Mohamad Alhazani, Badr Abdullah Aldahmash, Doaa Mohamed El-Nagar, Khalid Elfaki Ibrahim, Saheed Olaide Anifowose, Ahmed Mostafa Rady,
Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice,
Revista de Chimie,
Volume 72, Issue 2,
2021,
Pages 19-26,
ISSN 2668-8212,
https://doi.org/10.37358/RC.21.2.8416.
(https://revistadechimie.ro/Articles.asp?ID=8416)
Keywords: Hepatotoxicity; diclofenac; beet root; inflammation; oxidative stress

RIS
TY - JOUR
T1 - Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice
A1 - Alhazani, Tahani Mohamad
A2 - Aldahmash, Badr Abdullah
A3 - El-Nagar, Doaa Mohamed
A4 - Ibrahim, Khalid Elfaki
A5 - Anifowose, Saheed Olaide
A6 - Rady, Ahmed Mostafa
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2021
VL - 72
IS - 2
SP - 19
EP - 26
UR - https://doi.org/10.37358/RC.21.2.8416
KW - Hepatotoxicity
KW - diclofenac
KW - beet root
KW - inflammation
KW - oxidative stress
ER -

BibTex
@article{RevCh2021P19,
author = {Alhazani Tahani Mohamad and Aldahmash Badr Abdullah and El-Nagar Doaa Mohamed and Ibrahim Khalid Elfaki and Anifowose Saheed Olaide and Rady Ahmed Mostafa},
title = {Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice},
journal = {Revista de Chimie},
volume = {72},
number = {2},
pages = {19-26},
year = {2021},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.21.2.8416},
url = {https://revistadechimie.ro/Articles.asp?ID=8416}
}

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