Simple Electrochemical Synthesis of Pyrazolo<4,3-c>quinoline Derivatives

Alajmi, Sarah Fahad; Youssef, Tamer Ezzat

Sarah Fahad Alajmi, Tamer Ezzat Youssef

Simple Electrochemical Synthesis of Pyrazolo<4,3-c>quinoline Derivatives

Abstract:

Valuable pyrazolo[4,3-c]quinoline derivatives were synthesized efficiently from the easily available 7-Chloro-4-hydrazinoquinoline through electrochemical synthesis under moderate and scalable electrolytic conditions afforded linear hydrazones (3a-g) then the cyclized one (4a-g). The conduct of the reactions was performed in a simple undivided cell under constant current without oxidizing reagents or transition metal catalysts. The synthesized products of the cyclization reaction have been characterized via UV/Vis spectrophotometry, 1H-NMR and FTIR spectroscopy, the understanding of the mechanism of the reaction, the importance of reactant structure to control the rate of the reaction and equilibria in the process is substantial. The applying of this protocol to the effective synthesis of key intermediates for antidiabetic compounds was done.

Keywords:
Green chemistry; Quinoline; Heteroaromatic; Organic electrosynthesis

Issue: 2021, Volume 72, Issue 2

Pages: 50-58

Publication date: 2021/5/7

https://doi.org/10.37358/RC.21.2.8419

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ALAJMI, S.F., YOUSSEF, T.E., Simple Electrochemical Synthesis of Pyrazolo<4,3-c>quinoline Derivatives, Rev. Chim., 72(2), 2021, 50-58.

Vancouver
Alajmi SF, Youssef TE. Simple Electrochemical Synthesis of Pyrazolo<4,3-c>quinoline Derivatives. Rev. Chim.[internet]. 2021 Feb;72(2):50-58. Available from: https://doi.org/10.37358/RC.21.2.8419

APA 6th edition
Alajmi, S.F., Youssef, T.E. (2021). Simple Electrochemical Synthesis of Pyrazolo<4,3-c>quinoline Derivatives. Revista de Chimie, 72(2), 50-58. https://doi.org/10.37358/RC.21.2.8419

Harvard
Alajmi, S.F., Youssef, T.E. (2021). 'Simple Electrochemical Synthesis of Pyrazolo<4,3-c>quinoline Derivatives', Revista de Chimie, 72(2), pp. 50-58. https://doi.org/10.37358/RC.21.2.8419

IEEE
S.F. Alajmi, T.E. Youssef, "Simple Electrochemical Synthesis of Pyrazolo<4,3-c>quinoline Derivatives". Revista de Chimie, vol. 72, no. 2, pp. 50-58, 2021. [online]. https://doi.org/10.37358/RC.21.2.8419

Text
Sarah Fahad Alajmi, Tamer Ezzat Youssef,
Simple Electrochemical Synthesis of Pyrazolo<4,3-c>quinoline Derivatives,
Revista de Chimie,
Volume 72, Issue 2,
2021,
Pages 50-58,
ISSN 2668-8212,
https://doi.org/10.37358/RC.21.2.8419.
(https://revistadechimie.ro/Articles.asp?ID=8419)
Keywords: Green chemistry; Quinoline; Heteroaromatic; Organic electrosynthesis

RIS
TY - JOUR
T1 - Simple Electrochemical Synthesis of Pyrazolo<4,3-c>quinoline Derivatives
A1 - Alajmi, Sarah Fahad
A2 - Youssef, Tamer Ezzat
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2021
VL - 72
IS - 2
SP - 50
EP - 58
UR - https://doi.org/10.37358/RC.21.2.8419
KW - Green chemistry
KW - Quinoline
KW - Heteroaromatic
KW - Organic electrosynthesis
ER -

BibTex
@article{RevCh2021P50,
author = {Alajmi Sarah Fahad and Youssef Tamer Ezzat},
title = {Simple Electrochemical Synthesis of Pyrazolo<4,3-c>quinoline Derivatives},
journal = {Revista de Chimie},
volume = {72},
number = {2},
pages = {50-58},
year = {2021},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.21.2.8419},
url = {https://revistadechimie.ro/Articles.asp?ID=8419}
}

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