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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2006, Volume 57, Issue 4,





Obtaining and Physical-Chemical
Characterization of Inclusion Complex of a Sulphonamidic Diuretic with MethylatedƒnƒÒ-Cyclodextrine


Abstract:

Furosemide is a practically insoluble in water sulphonamidic diuretic, used for the treatment of edema and hypertension. Randomly-methylated-b-cyclodextrin(RAMEB) was used as a host molecule to improve its solubility in water, via inclusion complex formation. Different molar ratios (1:1, 1:2) and various preparation methods (physical mixing, kneading, ultrasonication) were used in order to obtain the inclusion complexes. Phase solubility diagram of furosemide and RAMEB was constructed and a diagram of AL type was obtained, with a stability constant of 130 M-1. The inclusion complexes were analysed by in vitro dissolution tests, differential scanning calorimetry and X-ray diffraction. As water solubility increased, the partition coefficients of the products decreased. Keywords: furosemide, RAMEB, inclusion complex


Issue: 2006, Volume 57, Issue 4
Pages:
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